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Esketamine Nasal Spray versus Quetiapine for Treatment-Resistant Depression.
Reif A, Bitter I, Buyze J, Cebulla K, Frey R, Fu DJ, Ito T, Kambarov Y, Llorca PM, Oliveira-Maia AJ, Messer T, Mulhern-Haughey S, Rive B, von Holt C, Young AH, Godinov Y; ESCAPE-TRD Investigators. Reif A, et al. N Engl J Med. 2023 Oct 5;389(14):1298-1309. doi: 10.1056/NEJMoa2304145. N Engl J Med. 2023. PMID: 37792613 Clinical Trial.
The primary end point was remission, defined as a score of 10 or less on the Montgomery-Asberg Depression Rating Scale (MADRS), at week 8 (scores range from 0 to 60, with higher scores indicating more severe depression). ...Over 32 weeks of follow-up, the percentage of pat …
The primary end point was remission, defined as a score of 10 or less on the Montgomery-Asberg Depression Rating Scale (MADRS), at we …
Comparison of behavioral activation-enhanced cognitive processing therapy and cognitive processing therapy among U.S. service members: A randomized clinical trial.
Walter KH, Hunt WM, Otis NP, Kline AC, Miggantz EL, Thomsen CJ, Glassman LH. Walter KH, et al. Psychiatry Res. 2023 Aug;326:115330. doi: 10.1016/j.psychres.2023.115330. Epub 2023 Jul 4. Psychiatry Res. 2023. PMID: 37418778 Free article. Clinical Trial.
The primary outcome was clinician-administered depression symptom severity on the Montgomery-Asberg Depression Rating Scale (MADRS) from pretreatment through 3-month follow-up. Intent-to-treat analyses using multilevel models showed statistically and clinically significant …
The primary outcome was clinician-administered depression symptom severity on the Montgomery-Asberg Depression Rating Scale (MADRS) f …
A randomized, double-blind, placebo-controlled study of citalopram in adolescents with major depressive disorder.
von Knorring AL, Olsson GI, Thomsen PH, Lemming OM, Hultén A. von Knorring AL, et al. J Clin Psychopharmacol. 2006 Jun;26(3):311-5. doi: 10.1097/01.jcp.0000219051.40632.d5. J Clin Psychopharmacol. 2006. PMID: 16702897 Clinical Trial.

The response rate was 59% to 61% in both groups according to the Schedule for Affective Disorders and Schizophrenia for school-aged children-Present episode version (Kiddie-SADS-P) (depression and anhedonia scores < or =2) and Montgomery Asberg Depression Rating Scale (MADR

…
The response rate was 59% to 61% in both groups according to the Schedule for Affective Disorders and Schizophrenia for school-aged children …
A double-blind, placebo-controlled study of quetiapine and lithium monotherapy in adults in the acute phase of bipolar depression (EMBOLDEN I).
Young AH, McElroy SL, Bauer M, Philips N, Chang W, Olausson B, Paulsson B, Brecher M; EMBOLDEN I (Trial 001) Investigators. Young AH, et al. J Clin Psychiatry. 2010 Feb;71(2):150-62. doi: 10.4088/JCP.08m04995gre. Epub 2010 Jan 26. J Clin Psychiatry. 2010. PMID: 20122369 Clinical Trial.
Primary endpoint was the change in Montgomery-Asberg Depression Rating Scale (MADRS) total score. The study was conducted from August 2005 to May 2007. ...Quetiapine 600 mg/d was significantly more effective than lithium in improving MADRS total score at week 8 (P = …
Primary endpoint was the change in Montgomery-Asberg Depression Rating Scale (MADRS) total score. The study was conducted from August …