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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1983 1
1984 1
1985 1
1986 2
1987 3
1988 3
1989 2
1990 1
1991 5
1992 9
1993 4
1994 6
1995 5
1996 7
1997 7
1998 13
1999 8
2000 16
2001 25
2002 12
2003 23
2004 41
2005 46
2006 43
2007 68
2008 79
2009 66
2010 102
2011 108
2012 136
2013 146
2014 158
2015 185
2016 187
2017 176
2018 185
2019 223
2020 247
2021 298
2022 368
2023 393
2024 189

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3,192 results

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Page 1
Pathophysiology of obesity and its associated diseases.
Jin X, Qiu T, Li L, Yu R, Chen X, Li C, Proud CG, Jiang T. Jin X, et al. Acta Pharm Sin B. 2023 Jun;13(6):2403-2424. doi: 10.1016/j.apsb.2023.01.012. Epub 2023 Jan 13. Acta Pharm Sin B. 2023. PMID: 37425065 Free PMC article. Review.
Although some progress in the treatment of obesity has been achieved in preclinical and clinical studies, the progression and pathogenesis of obesity-induced diseases are complex and unclear. We still need to understand their links to better guide the treatment of obesity …
Although some progress in the treatment of obesity has been achieved in preclinical and clinical studies, the progression and pathogenesis o …
Phospholipids with two polyunsaturated fatty acyl tails promote ferroptosis.
Qiu B, Zandkarimi F, Bezjian CT, Reznik E, Soni RK, Gu W, Jiang X, Stockwell BR. Qiu B, et al. Cell. 2024 Feb 29;187(5):1177-1190.e18. doi: 10.1016/j.cell.2024.01.030. Epub 2024 Feb 15. Cell. 2024. PMID: 38366593
Depletion of PC-PUFA(2)s occurred in aging and Huntington's disease brain tissue, linking it to ferroptosis. Notably, PC-PUFA(2)s interacted with the mitochondrial electron transport chain, generating reactive oxygen species (ROS) for initiating lipid peroxidation. ...
Depletion of PC-PUFA(2)s occurred in aging and Huntington's disease brain tissue, linking it to ferroptosis. Notably, PC-PUFA(2)s int …
Key Molecules of Fatty Acid Metabolism in Gastric Cancer.
Li C, Zhang L, Qiu Z, Deng W, Wang W. Li C, et al. Biomolecules. 2022 May 15;12(5):706. doi: 10.3390/biom12050706. Biomolecules. 2022. PMID: 35625633 Free PMC article. Review.
Fatty acid metabolism is closely linked to the progression of gastric cancer (GC), a very aggressive and life-threatening tumor. ...Fatty acid absorption is mediated by CD36 and FABPs, and fatty acid catabolism is mediated by CPT1. If at all possible, we will discover nove …
Fatty acid metabolism is closely linked to the progression of gastric cancer (GC), a very aggressive and life-threatening tumor. ...F …
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation.
Yao J, Wu D, Zhang C, Yan T, Zhao Y, Shen H, Xue K, Huang X, Wang Z, Qiu Y. Yao J, et al. Nat Immunol. 2021 Oct;22(10):1268-1279. doi: 10.1038/s41590-021-01023-y. Epub 2021 Sep 23. Nat Immunol. 2021. PMID: 34556885
Metabolic inflammation is closely linked to obesity, and is implicated in the pathogenesis of metabolic diseases. ...
Metabolic inflammation is closely linked to obesity, and is implicated in the pathogenesis of metabolic diseases. ...
The Hippo pathway links adipocyte plasticity to adipose tissue fibrosis.
Shen H, Huang X, Zhao Y, Wu D, Xue K, Yao J, Wang Y, Tang N, Qiu Y. Shen H, et al. Nat Commun. 2022 Oct 13;13(1):6030. doi: 10.1038/s41467-022-33800-0. Nat Commun. 2022. PMID: 36229481 Free PMC article.
Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction upon chronic caloric excess. The molecular mechanisms linking adipocyte plasticity to AT fibrosis are largely unknown. Here we show that the Hippo pathway is coupled with TGFbeta signal …
Fibrosis disrupts adipose tissue (AT) homeostasis and exacerbates metabolic dysfunction upon chronic caloric excess. The molecular mechanism …
Cicero Predicts cis-Regulatory DNA Interactions from Single-Cell Chromatin Accessibility Data.
Pliner HA, Packer JS, McFaline-Figueroa JL, Cusanovich DA, Daza RM, Aghamirzaie D, Srivatsan S, Qiu X, Jackson D, Minkina A, Adey AC, Steemers FJ, Shendure J, Trapnell C. Pliner HA, et al. Mol Cell. 2018 Sep 6;71(5):858-871.e8. doi: 10.1016/j.molcel.2018.06.044. Epub 2018 Aug 2. Mol Cell. 2018. PMID: 30078726 Free PMC article.
Linking regulatory DNA elements to their target genes, which may be located hundreds of kilobases away, remains challenging. ...We apply Cicero to investigate how dynamically accessible elements orchestrate gene regulation in differentiating myoblasts. Groups of Cicero- …
Linking regulatory DNA elements to their target genes, which may be located hundreds of kilobases away, remains challenging. ...We ap …
Ketosis and diabetic ketoacidosis in response to SGLT2 inhibitors: Basic mechanisms and therapeutic perspectives.
Qiu H, Novikov A, Vallon V. Qiu H, et al. Diabetes Metab Res Rev. 2017 Jul;33(5). doi: 10.1002/dmrr.2886. Epub 2017 Feb 23. Diabetes Metab Res Rev. 2017. PMID: 28099783 Review.
This provides the rationale for measures to lower the risk. We discuss the role of the kidney and potential links to renal gluconeogenesis and uric acid handling. Moreover, we outline potential beneficial effects of modestly elevated ketone body levels on organ function th …
This provides the rationale for measures to lower the risk. We discuss the role of the kidney and potential links to renal gluconeoge …
The mitochondrial calcium uniporter engages UCP1 to form a thermoporter that promotes thermogenesis.
Xue K, Wu D, Wang Y, Zhao Y, Shen H, Yao J, Huang X, Li X, Zhou Z, Wang Z, Qiu Y. Xue K, et al. Cell Metab. 2022 Sep 6;34(9):1325-1341.e6. doi: 10.1016/j.cmet.2022.07.011. Epub 2022 Aug 16. Cell Metab. 2022. PMID: 35977541 Free article.
Remarkably, the enhanced assembly of the thermogenic uniporter via Micu1 knockout or expressing linked EMRE-UCP1 results in opposite phenotypes. Thus, we have uncovered a "thermoporter" that provides a driving force for the UCP1 operation in thermogenesis, which could be l …
Remarkably, the enhanced assembly of the thermogenic uniporter via Micu1 knockout or expressing linked EMRE-UCP1 results in opposite …
Psoriasis and cardiovascular disease risk in European and East Asian populations: evidence from meta-analysis and Mendelian randomization analysis.
Zhang L, Wang Y, Qiu L, Wu J. Zhang L, et al. BMC Med. 2022 Nov 1;20(1):421. doi: 10.1186/s12916-022-02617-5. BMC Med. 2022. PMID: 36320003 Free PMC article. Review.
BACKGROUND: Psoriasis has been linked to cardiovascular disease (CVD), including coronary artery disease (CAD), myocardial infarction (MI), and heart failure (HF). ...These results not only increase our knowledge of the genetic underpinnings linking a comorbidity of …
BACKGROUND: Psoriasis has been linked to cardiovascular disease (CVD), including coronary artery disease (CAD), myocardial infarction …
Anosmia, mild cognitive impairment, and biomarkers of brain aging in older adults.
Dong Y, Li Y, Liu K, Han X, Liu R, Ren Y, Cong L, Zhang Q, Hou T, Song L, Tang S, Shi L, Luo Y, Kalpouzos G, Laukka EJ, Winblad B, Wang Y, Du Y, Qiu C. Dong Y, et al. Alzheimers Dement. 2023 Feb;19(2):589-601. doi: 10.1002/alz.12777. Epub 2022 Sep 15. Alzheimers Dement. 2023. PMID: 36341691
These results suggest that cerebral neurodegenerative and microvascular lesions are common neuropathologies linking anosmia with MCI in older adults....
These results suggest that cerebral neurodegenerative and microvascular lesions are common neuropathologies linking anosmia with MCI …
3,192 results