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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1954 1
1955 1
1957 2
1967 1
1968 12
1969 5
1970 14
1971 23
1972 29
1973 23
1974 16
1975 44
1976 36
1977 36
1978 36
1979 40
1980 124
1981 250
1982 252
1983 338
1984 413
1985 459
1986 485
1987 517
1988 546
1989 550
1990 653
1991 694
1992 815
1993 767
1994 929
1995 938
1996 925
1997 906
1998 903
1999 1066
2000 1169
2001 1284
2002 1299
2003 1387
2004 1495
2005 1677
2006 1800
2007 1948
2008 2090
2009 2201
2010 2654
2011 2802
2012 2743
2013 2797
2014 2688
2015 2678
2016 2470
2017 2455
2018 2498
2019 2429
2020 2532
2021 2398
2022 1586
2023 1497
2024 591

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58,723 results

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Page 1
Lysyl oxidases: from enzyme activity to extracellular matrix cross-links.
Vallet SD, Ricard-Blum S. Vallet SD, et al. Essays Biochem. 2019 Sep 13;63(3):349-364. doi: 10.1042/EBC20180050. Print 2019 Sep 13. Essays Biochem. 2019. PMID: 31488698 Review.
We review here the molecular features and three-dimensional structure/models of LOX and LOXLs, their role in ECM cross-linking, and the regulation of their cross-linking activity by ECM proteins, proteoglycans, and by inhibitors. We also make an overview of t …
We review here the molecular features and three-dimensional structure/models of LOX and LOXLs, their role in ECM cross-linking, and t …
Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes.
Karam BS, Chavez-Moreno A, Koh W, Akar JG, Akar FG. Karam BS, et al. Cardiovasc Diabetol. 2017 Sep 29;16(1):120. doi: 10.1186/s12933-017-0604-9. Cardiovasc Diabetol. 2017. PMID: 28962617 Free PMC article. Review.
The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mechanistic links. In this article we provide an update on the growing evidence linking oxidative stress and inflammation to advers …
The growing recognition that obesity, diabetes and AF are closely intertwined disorders has spurred major interest in uncovering their mecha …
Collagen cross-linking mediated by lysyl hydroxylase 2: an enzymatic battlefield to combat fibrosis.
Piersma B, Bank RA. Piersma B, et al. Essays Biochem. 2019 Sep 13;63(3):377-387. doi: 10.1042/EBC20180051. Print 2019 Sep 13. Essays Biochem. 2019. PMID: 31324706 Review.
Not only the level of cross-linking is increased, but also the composition of cross-linking is altered: an increase is seen in hydroxyallysine-derived cross-links at the expense of allysine cross-links. ...In this review, we discuss the molecular basis …
Not only the level of cross-linking is increased, but also the composition of cross-linking is altered: an increase is seen in …
New insights into different adipokines in linking the pathophysiology of obesity and psoriasis.
Kong Y, Zhang S, Wu R, Su X, Peng D, Zhao M, Su Y. Kong Y, et al. Lipids Health Dis. 2019 Sep 14;18(1):171. doi: 10.1186/s12944-019-1115-3. Lipids Health Dis. 2019. PMID: 31521168 Free PMC article. Review.
Currently, growing evidence has pointed to the central role of adipokines in adipose tissue and the immune system, providing new insights into the effect of adipokines in linking the pathophysiology of obesity and psoriasis. In this review, we summarize the current underst …
Currently, growing evidence has pointed to the central role of adipokines in adipose tissue and the immune system, providing new insights in …
Tribbles and arthritis: what are the links?
Rowan AD, Litherland GJ. Rowan AD, et al. Biochem Soc Trans. 2015 Oct;43(5):1051-6. doi: 10.1042/BST20150076. Biochem Soc Trans. 2015. PMID: 26517922 Review.
The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have functionally divergent roles with respect to intracellular protein degradation and the ability to regulate signal transduction pathways. In the …
The pseudo-kinase family of tribbles (TRIB) proteins has been linked to a variety of cell signalling pathways and appears to have fun …
Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases.
Croft M, Siegel RM. Croft M, et al. Nat Rev Rheumatol. 2017 Apr;13(4):217-233. doi: 10.1038/nrrheum.2017.22. Epub 2017 Mar 9. Nat Rev Rheumatol. 2017. PMID: 28275260 Free PMC article. Review.
In this Review, we focus on additional members of the TNF superfamily that could be relevant for the pathogenesis of rheumatic disease, including those that can strongly promote activity of immune cells or increase activity of tissue cells, as well as those that promote death pat …
In this Review, we focus on additional members of the TNF superfamily that could be relevant for the pathogenesis of rheumatic disease, incl …
O-GlcNAc in cancer biology.
Ma Z, Vosseller K. Ma Z, et al. Amino Acids. 2013 Oct;45(4):719-33. doi: 10.1007/s00726-013-1543-8. Epub 2013 Jul 9. Amino Acids. 2013. PMID: 23836420 Review.
O-linked beta-N-actylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or threonine residues of cytosolic and nuclear proteins. ...In this review, we describe known/potential links between hyper-O-GlcNAcylation …
O-linked beta-N-actylglucosamine (O-GlcNAc) is a carbohydrate post-translational modification on hydroxyl groups of serine and/or thr …
Mechanisms linking leptin to arterial and venous thrombosis: potential pharmacological targets.
Schäfer K, Konstantinides S. Schäfer K, et al. Curr Pharm Des. 2014;20(4):635-40. doi: 10.2174/13816128113199990021. Curr Pharm Des. 2014. PMID: 23688015 Review.
Epidemiological evidence strongly links excess body weight with an increased risk to develop atherothrombotic complications. ...
Epidemiological evidence strongly links excess body weight with an increased risk to develop atherothrombotic complications. ...
Novel Compound Inhibitors of HIV-1(NL4-3) Vpu.
Robinson CA, Lyddon TD, Gil HM, Evans DT, Kuzmichev YV, Richard J, Finzi A, Welbourn S, Rasmussen L, Nebane NM, Gupta VV, Ananthan S, Cai Z, Wonderlich ER, Augelli-Szafran CE, Bostwick R, Ptak RG, Schader SM, Johnson MC. Robinson CA, et al. Viruses. 2022 Apr 15;14(4):817. doi: 10.3390/v14040817. Viruses. 2022. PMID: 35458546 Free PMC article.
Using this assay, a high throughput screen of >650,000 compounds was performed to identify inhibitors that block the biological activity of Vpu. From this screen, we identified several positive hits but focused on two compounds from one structural family, SRI-41897 and …
Using this assay, a high throughput screen of >650,000 compounds was performed to identify inhibitors that block the biological ac …
VISTA: A Target to Manage the Innate Cytokine Storm.
ElTanbouly MA, Zhao Y, Schaafsma E, Burns CM, Mabaera R, Cheng C, Noelle RJ. ElTanbouly MA, et al. Front Immunol. 2021 Feb 11;11:595950. doi: 10.3389/fimmu.2020.595950. eCollection 2020. Front Immunol. 2021. PMID: 33643285 Free PMC article. Review.
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