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Year Number of Results
1978 1
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1985 1
1986 1
1988 2
1989 4
1990 1
1991 5
1992 4
1993 7
1994 5
1995 8
1996 10
1997 16
1998 8
1999 12
2000 20
2001 26
2002 24
2003 17
2004 37
2005 53
2006 51
2007 74
2008 75
2009 72
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2020 293
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2024 128

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3,294 results

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Page 1
Fusion protein linkers: property, design and functionality.
Chen X, Zaro JL, Shen WC. Chen X, et al. Adv Drug Deliv Rev. 2013 Oct;65(10):1357-69. doi: 10.1016/j.addr.2012.09.039. Epub 2012 Sep 29. Adv Drug Deliv Rev. 2013. PMID: 23026637 Free PMC article. Review.
The general properties of linkers derived from naturally-occurring multi-domain proteins can be considered as the foundation in linker design. Empirical linkers designed by researchers are generally classified into 3 categories according to their structures: …
The general properties of linkers derived from naturally-occurring multi-domain proteins can be considered as the foundation in li …
Research advances in peptide‒drug conjugates.
Gong L, Zhao H, Liu Y, Wu H, Liu C, Chang S, Chen L, Jin M, Wang Q, Gao Z, Huang W. Gong L, et al. Acta Pharm Sin B. 2023 Sep;13(9):3659-3677. doi: 10.1016/j.apsb.2023.02.013. Epub 2023 Feb 28. Acta Pharm Sin B. 2023. PMID: 37719380 Free PMC article. Review.
Peptide-drug conjugates (PDCs) are drug delivery systems consisting of a drug covalently coupled to a multifunctional peptide via a cleavable linker. As an emerging prodrug strategy, PDCs not only preserve the function and bioactivity of the peptides but also release the d …
Peptide-drug conjugates (PDCs) are drug delivery systems consisting of a drug covalently coupled to a multifunctional peptide via a cleavabl …
Post-synthetic modifications of metal-organic cages.
Liu J, Wang Z, Cheng P, Zaworotko MJ, Chen Y, Zhang Z. Liu J, et al. Nat Rev Chem. 2022 May;6(5):339-356. doi: 10.1038/s41570-022-00380-y. Epub 2022 Apr 4. Nat Rev Chem. 2022. PMID: 37117929 Review.
Metal-organic cages (MOCs) are discrete, supramolecular entities that consist of metal nodes and organic linkers, which can offer solution processability and high porosity. Thereby, their predesigned structures can undergo post-synthetic modifications (PSMs) to introduce n …
Metal-organic cages (MOCs) are discrete, supramolecular entities that consist of metal nodes and organic linkers, which can offer sol …
Structures and Functions of Chromatin Fibers.
Chen P, Li W, Li G. Chen P, et al. Annu Rev Biophys. 2021 May 6;50:95-116. doi: 10.1146/annurev-biophys-062920-063639. Annu Rev Biophys. 2021. PMID: 33957053 Review.
All of the factors that affect the structure and dynamics of nucleosomes, the nucleosome-nucleosome interaction interfaces, and the binding of linker histones or other chromatin-binding proteins need to be considered to understand the organization and function of chromatin …
All of the factors that affect the structure and dynamics of nucleosomes, the nucleosome-nucleosome interaction interfaces, and the binding …
Activity-based proteomic profiling: application of releasable linker in photoaffinity probes.
Wang J, Chen Q, Shan Y, Pan X, Zhang J. Wang J, et al. Drug Discov Today. 2020 Jan;25(1):133-140. doi: 10.1016/j.drudis.2019.10.016. Epub 2019 Nov 7. Drug Discov Today. 2020. PMID: 31707121 Review.
The biomacromolecule photoaffinity probe prepared by using releasable photoaffinity linkers can be used to exploring PPIs by triggering release of the releasable group. ...In this review, we highlight recent progress in the development and application of chemical releasabl …
The biomacromolecule photoaffinity probe prepared by using releasable photoaffinity linkers can be used to exploring PPIs by triggeri …
Discovery of novel BTK PROTACs with improved metabolic stability via linker rigidification strategy.
Chen S, Chen Z, Lu L, Zhao Y, Zhou R, Xie Q, Shu Y, Lin J, Yu X, Wang Y. Chen S, et al. Eur J Med Chem. 2023 Jul 5;255:115403. doi: 10.1016/j.ejmech.2023.115403. Epub 2023 Apr 20. Eur J Med Chem. 2023. PMID: 37119666
Herein, we present our structure-activity relationship (SAR) studies on modifying PROTAC 6e using linker rigidification strategy to identify a novel cereblon (CRBN)-recruiting compound 3e that induced BTK degradation in a concentration-dependent manner but had no effect on …
Herein, we present our structure-activity relationship (SAR) studies on modifying PROTAC 6e using linker rigidification strategy to i …
Entropy-controlled cross-linking in linker-mediated vitrimers.
Lei QL, Xia X, Yang J, Pica Ciamarra M, Ni R. Lei QL, et al. Proc Natl Acad Sci U S A. 2020 Nov 3;117(44):27111-27115. doi: 10.1073/pnas.2015672117. Epub 2020 Oct 21. Proc Natl Acad Sci U S A. 2020. PMID: 33087578 Free PMC article.
We find that, with increasing the linker concentration, vitrimers undergo a reentrant gel-sol transition, which explains a recent experiment [S. Wu, H. Yang, S. Huang, Q. Chen, Macromolecules 53, 1180-1190 (2020)]. More intriguingly, at the low temperature limit, th …
We find that, with increasing the linker concentration, vitrimers undergo a reentrant gel-sol transition, which explains a recent exp …
Multifunctional porous hydrogen-bonded organic framework materials.
Lin RB , He Y , Li P , Wang H , Zhou W , Chen B . Lin RB , et al. Chem Soc Rev. 2019 Mar 4;48(5):1362-1389. doi: 10.1039/c8cs00155c. Chem Soc Rev. 2019. PMID: 30676603 Review.
Hydrogen-bonded organic frameworks (HOFs) represent an interesting type of polymeric porous materials that can be self-assembled through H-bonding between organic linkers. To realize permanent porosity in HOFs, stable and robust open frameworks can be constructed by judici …
Hydrogen-bonded organic frameworks (HOFs) represent an interesting type of polymeric porous materials that can be self-assembled through H-b …
3D based generative PROTAC linker design with reinforcement learning.
Li B, Ran T, Chen H. Li B, et al. Brief Bioinform. 2023 Sep 20;24(5):bbad323. doi: 10.1093/bib/bbad323. Brief Bioinform. 2023. PMID: 37670499
The rational PROTAC linker design is challenging due to its relatively large molecular weight and the complexity of maintaining the binding mode of warhead and E3-ligand in the binding pockets of counterpart. Conventional linker generation method can only generate …
The rational PROTAC linker design is challenging due to its relatively large molecular weight and the complexity of maintaining the b …
Oxidative-Species-Selective Materials for Diagnostic and Therapeutic Applications.
Zhao C, Chen J, Zhong R, Chen DS, Shi J, Song J. Zhao C, et al. Angew Chem Int Ed Engl. 2021 Apr 26;60(18):9804-9827. doi: 10.1002/anie.201915833. Epub 2020 Oct 29. Angew Chem Int Ed Engl. 2021. PMID: 32285531 Review.
In this review, we first discuss the distinct features and biological functions of each oxidative species. Then the selectivity and sensitivity of chemical linkers/groups to specific oxidative species and the underlying chemistry of their particular interactions are system …
In this review, we first discuss the distinct features and biological functions of each oxidative species. Then the selectivity and sensitiv …
3,294 results