Boiling water-catalyzed neutral and selective N-Boc deprotection

Chem Commun (Camb). 2009 Sep 14:(34):5144-6. doi: 10.1039/b910239f. Epub 2009 Jul 31.

Abstract

A general protocol for removing Boc groups from various types of nitrogen is reported and a preliminary investigation of the reaction mechanism indicates that water acts as a dual acid/base catalyst at elevated temperature.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Formic Acid Esters / chemistry*
  • Hot Temperature*
  • Molecular Structure
  • Stereoisomerism
  • Water / chemistry*

Substances

  • Formic Acid Esters
  • t-butyloxycarbonyl group
  • Water