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Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors.
Montalban-Arques A, Katkeviciute E, Busenhart P, Bircher A, Wirbel J, Zeller G, Morsy Y, Borsig L, Glaus Garzon JF, Müller A, Arnold IC, Artola-Boran M, Krauthammer M, Sintsova A, Zamboni N, Leventhal GE, Berchtold L, de Wouters T, Rogler G, Baebler K, Schwarzfischer M, Hering L, Olivares-Rivas I, Atrott K, Gottier C, Lang S, Boyman O, Fritsch R, Manz MG, Spalinger MR, Scharl M. Montalban-Arques A, et al. Cell Host Microbe. 2021 Oct 13;29(10):1573-1588.e7. doi: 10.1016/j.chom.2021.08.001. Epub 2021 Aug 27. Cell Host Microbe. 2021. PMID: 34453895 Free article.
Decoding breast milk oligosaccharides.
Hennet T, Weiss A, Borsig L. Hennet T, et al. Swiss Med Wkly. 2014 Feb 19;144:w13927. doi: 10.4414/smw.2014.13927. Swiss Med Wkly. 2014. PMID: 24554478 Free article. Review.
The application of mouse models allows the investigation of unique milk oligosaccharides in the context of intestinal microbiota and mucosal immunity. In this respect, our recent work has demonstrated that uptake of the milk oligosaccharide 3-sialyllactose increases the in …
The application of mouse models allows the investigation of unique milk oligosaccharides in the context of intestinal microbiota and mucosal …
Exploring and Exploiting the Effect of Solvent Treatment in Membrane Separations.
Razali M, Didaskalou C, Kim JF, Babaei M, Drioli E, Lee YM, Szekely G. Razali M, et al. ACS Appl Mater Interfaces. 2017 Mar 29;9(12):11279-11289. doi: 10.1021/acsami.7b01879. Epub 2017 Mar 20. ACS Appl Mater Interfaces. 2017. PMID: 28276673
Nine solvents with polarity indices ranging from 0.1 to 5.8 (hexane to acetonitrile) were used as treatment and process solvents on commercial Borsig GMT-oNF-2, Evonik Duramem 300, and emerging tailor-made polybenzimidazole membranes. TGA-GCMS, HS-GC-FID, and NMR technique …
Nine solvents with polarity indices ranging from 0.1 to 5.8 (hexane to acetonitrile) were used as treatment and process solvents on commerci …
Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis.
Borsig L, Wong R, Hynes RO, Varki NM, Varki A. Borsig L, et al. Proc Natl Acad Sci U S A. 2002 Feb 19;99(4):2193-8. doi: 10.1073/pnas.261704098. Proc Natl Acad Sci U S A. 2002. PMID: 11854515 Free PMC article.
P-selectin facilitates human carcinoma metastasis in immunodeficient mice by mediating early interactions of platelets with bloodborne tumor cells via their cell surface mucins, and this process can be blocked by heparin [Borsig, L., Wong, R., Feramisco, J., Nadeau, D. R., …
P-selectin facilitates human carcinoma metastasis in immunodeficient mice by mediating early interactions of platelets with bloodborne tumor …
Analysis of serum glycome by lectin microarrays for prostate cancer patients - a search for aberrant glycoforms.
Bertok T, Jane E, Chrenekova N, Hroncekova S, Bertokova A, Hires M, Vikartovska A, Kubanikova P, Sokol R, Fillo J, Kasak P, Borsig L, Tkac J. Bertok T, et al. Glycoconj J. 2020 Dec;37(6):703-711. doi: 10.1007/s10719-020-09958-4. Epub 2020 Oct 29. Glycoconj J. 2020. PMID: 33119808 Free article.
This is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of serum samples from healthy individuals, benign prostate hyperplasia (BPH) patients, and prostate cancer (PCa) patients. ...
This is the first work focused on glycoprofiling of whole N- and O- glycome using lectins in an array format applied for analysis of …
Sulfated fucans and a sulfated galactan from sea urchins as potent inhibitors of selectin-dependent hematogenous metastasis.
Teixeira FCOB, Kozlowski EO, Micheli KVA, Vilela-Silva ACES, Borsig L, Pavão MSG. Teixeira FCOB, et al. Glycobiology. 2018 Jun 1;28(6):427-434. doi: 10.1093/glycob/cwy020. Glycobiology. 2018. PMID: 29522135 Free article.
Similarly, other sulfated polysaccharides isolated from marine invertebrates attenuate metastasis by a P-selectin-mediated mechanism. In this work, we investigated the selectin-dependent antimetastatic activity of sea urchin sulfated polysaccharides with slight structural …
Similarly, other sulfated polysaccharides isolated from marine invertebrates attenuate metastasis by a P-selectin-mediated mechanism. In thi …
Non-Anticoagulant Heparan Sulfate from the Ascidian Phallusia nigra Prevents Colon Carcinoma Metastasis in Mice by Disrupting Platelet-Tumor Cell Interaction.
Silva CFS, Motta JM, Teixeira FCOB, Gomes AM, Vilanova E, Kozlowski EO, Borsig L, Pavão MSG. Silva CFS, et al. Cancers (Basel). 2020 May 26;12(6):1353. doi: 10.3390/cancers12061353. Cancers (Basel). 2020. PMID: 32466418 Free PMC article.
Oversulfated dermatan sulfates from ascidians are effective in preventing metastasis by inhibition of P-selectin, a platelet surface protein involved in the platelet-tumor cell emboli formation. We report in this work that the heparan sulfate isolated from the viscera of t …
Oversulfated dermatan sulfates from ascidians are effective in preventing metastasis by inhibition of P-selectin, a platelet surface protein …
Stromal Expression of Activated Leukocyte Cell Adhesion Molecule Promotes Lung Tumor Growth and Metastasis.
Willrodt AH, Beffinger M, Vranova M, Protsyuk D, Schuler K, Jadhav M, Heikenwalder M, van den Broek M, Borsig L, Halin C. Willrodt AH, et al. Am J Pathol. 2017 Nov;187(11):2558-2569. doi: 10.1016/j.ajpath.2017.07.008. Epub 2017 Aug 17. Am J Pathol. 2017. PMID: 28822802 Free article.
Similarly, when LLC cells were implanted subcutaneously for the study of spontaneous tumor cell metastasis, the rate of LLC metastasis to the lungs was profoundly reduced in ALCAM(-/-) mice. Taken together, our work demonstrates for the first time the in vivo contribution …
Similarly, when LLC cells were implanted subcutaneously for the study of spontaneous tumor cell metastasis, the rate of LLC metastasis to th …
Complete absence of the αGal xenoantigen and isoglobotrihexosylceramide in α1,3galactosyltransferase knock-out pigs.
Puga Yung GL, Li Y, Borsig L, Millard AL, Karpova MB, Zhou D, Seebach JD. Puga Yung GL, et al. Xenotransplantation. 2012 May-Jun;19(3):196-206. doi: 10.1111/j.1399-3089.2012.00705.x. Xenotransplantation. 2012. PMID: 22702471 Free PMC article.
The glycosphingolipid isoglobotrihexosylceramide (iGb3) represents such a candidate expressing an alternative Galalpha1,3Gal epitope. The present work determined whether the terminal Galalpha1,3Gal disaccharide is completely absent in Immerge pigs lacking the GalT using se …
The glycosphingolipid isoglobotrihexosylceramide (iGb3) represents such a candidate expressing an alternative Galalpha1,3Gal epitope. The pr …
11 results