Vitamin E containing polymer micelles for reducing normal cell cytotoxicity and enhancing chemotherapy efficacy

Kuan-Yi Lee; Yi-Ting Chiang; Ning-Yu Hsu; Chieh-Yu Yang; Chun-Liang Lo; Chen-An Ku

doi:10.1016/j.actbio.2015.06.014

Vitamin E containing polymer micelles for reducing normal cell cytotoxicity and enhancing chemotherapy efficacy

Acta Biomater. 2015 Sep:24:286-96. doi: 10.1016/j.actbio.2015.06.014. Epub 2015 Jun 16.

Authors

Kuan-Yi Lee¹, Yi-Ting Chiang¹, Ning-Yu Hsu¹, Chieh-Yu Yang¹, Chun-Liang Lo², Chen-An Ku³

Affiliations

¹ Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan.
² Department of Biomedical Engineering, National Yang Ming University, Taipei 112, Taiwan; Biophotonics & Molecular Imaging Research Center (BMIRC), National Yang Ming University, Taipei 112, Taiwan; Biomedical Engineering Research Center, National Yang Ming University, Taipei 112, Taiwan. Electronic address: cllo@ym.edu.tw.
³ Taiwan Textile Research Institute, New Taipei City 23674, Taiwan.

PMID: 26087112
DOI: 10.1016/j.actbio.2015.06.014

Abstract

An α-tocopheryl succinate (α-TOS) containing diblock copolymer micellar system was used to deliver doxorubicin (Dox), an anticancer drug, for HCT116 colon cancer therapy. The α-TOS containing diblock copolymers were synthesized by conjugation of α-TOS molecules and a mPEG-b-PHEMA hydrophilic diblock copolymer by ester bonds. The Dox-loaded polymeric micelles were then obtained by solvent exchange process. In acidic surroundings such as endosomes or secondary lysosomes, the structures of the Dox-loaded polymeric micelles deformed and released the drug loads. Additionally, Dox-loaded polymeric micelles enhanced the cytotoxicity of Dox and α-TOS to cancer cells in vitro. Dox-loaded polymeric micelles also showed an exceptional tumor inhibiting effect in vivo. This study indicates that the α-TOS containing polymeric micelle system can be used as a drug carrier for cancer therapy.

Keywords: Cancer therapy; Doxorubicin; Intracellular drug delivery; Micelles; α-Tocopheryl succinate.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Line, Tumor
Doxorubicin* / chemistry
Doxorubicin* / pharmacology
Drug Carriers* / chemistry
Drug Carriers* / pharmacology
Humans
Mice
Micelles*
Neoplasms / drug therapy*
Neoplasms / metabolism
Neoplasms / pathology
alpha-Tocopherol* / chemistry
alpha-Tocopherol* / pharmacology

Substances

Drug Carriers
Micelles
Doxorubicin
alpha-Tocopherol