Cellular internalization mechanism of novel Raman probes designed for plant cells

RSC Chem Biol. 2020 Aug 20;1(4):204-208. doi: 10.1039/d0cb00128g. eCollection 2020 Oct 1.

Abstract

Diphenylacetylene derivatives containing different polymeric components, poly(l-lysine) (pLys) or tetra(ethylene glycol) (TEG) were designed as novel Raman imaging probes with high Raman sensitivity and low cytotoxicity in living plant cells. The pLys-conjugated probe is internalized via an endocytosis-dependent pathway, whereas TEG-conjugated probe most likely induces direct penetration into the plant cells.