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Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015.
Nanda VGY, Peng W, Hwu P, Davies MA, Ciliberto G, Fattore L, Malpicci D, Aurisicchio L, Ascierto PA, Croce CM, Mancini R, Spranger S, Gajewski TF, Wang Y, Ferrone S, Vanpouille-Box C, Wennerberg E, Pilones KA, Formenti SC, Demaria S, Tang H, Wang Y, Fu YX, Dummer R, Puzanov I, Tarhini A, Chauvin JM, Pagliano O, Fourcade J, Sun Z, Wang H, Sanders C, Kirkwood JM, Chen THT, Maurer M, Korman AJ, Zarour HM, Stroncek DF, Huber V, Rivoltini L, Thurin M, Rau T, Lugli A, Pagès F, Camarero J, Sancho A, Jommi C, de Coaña YP, Wolodarski M, Yoshimoto Y, Gentilcore G, Poschke I, Masucci GV, Hansson J, Kiessling R, Scognamiglio G, Sabbatino F, Marino FZ, Anniciello AM, Cantile M, Cerrone M, Scala S, D’alterio C, Ianaro A, Cirin G, Liguori G, Bott G, Chapman PB, Robert C, Larkin J, Haanen JB, Ribas A, Hogg D, Hamid O, Testori A, Lorigan P, Sosman JA, Flaherty KT, Yue H, Coleman S, Caro I, Hauschild A, McArthur GA, Sznol M, Callahan MK, Kluger H, Postow MA, Gordan R, Segal NH, Rizvi NA, Lesokhin A, Atkins MB, Burke MM, Ralabate A, Rivera A, Kronenberg SA, Agunwamba B, Ruisi M, Horak C, Jiang J, Wolchok J, Ascierto PA, Liszkay G, Maio M, Mandalà M, Demidov L, Stoyakovskiy D, Thomas L, de la Cruz-Me… See abstract for full author list ➔ Nanda VGY, et al. J Transl Med. 2016 Jul 25;14(1):65. doi: 10.1186/s12967-016-0791-2. J Transl Med. 2016. PMID: 27461275 Free PMC article.
MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AKT/mTOR activation in melanoma Vashisht G. ...Ascierto, Emilia Caputo P2 Anti-proliferative and pro-apoptotic effect of ABT888 on m …
MELANOMA BRIDGE 2015 KEYNOTE SPEAKER PRESENTATIONS Molecular and immuno-advances K1 Immunologic and metabolic consequences of PI3K/AK …
Intraocular Inflammation Associated with New Therapies for Cutaneous Melanoma - Case Series and Review.
Fierz FC, Meier F, Chaloupka K, Böni C. Fierz FC, et al. Klin Monbl Augenheilkd. 2016 Apr;233(4):540-4. doi: 10.1055/s-0042-102668. Epub 2016 Apr 26. Klin Monbl Augenheilkd. 2016. PMID: 27116532 Review. English.
We describe the clinical presentation of uveitis in three patients with concomitant systemic melanoma treatment. History and Signs. Three patients with metastatic melanoma receiving systemic therapy (ipilimumab, vemurafenib) presented at our institution with a short …
We describe the clinical presentation of uveitis in three patients with concomitant systemic melanoma treatment. History and Signs. T …
Somatostatin Receptors as Molecular Targets in Human Uveal Melanoma.
Harda K, Szabo Z, Szabo E, Olah G, Fodor K, Szasz C, Mehes G, Schally AV, Halmos G. Harda K, et al. Molecules. 2018 Jun 26;23(7):1535. doi: 10.3390/molecules23071535. Molecules. 2018. PMID: 29949880 Free PMC article.
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with an incidence of 4-5 cases per million. ...
Uveal melanoma (UM) is the most common primary intraocular malignancy in adults, with an incidence of 4-5 cases per million. ...
Monosomy-3 Alters the Expression Profile of the Glucose Transporters GLUT1-3 in Uveal Melanoma.
Maaßen T, Vardanyan S, Brosig A, Merz H, Ranjbar M, Kakkassery V, Grisanti S, Tura A. Maaßen T, et al. Int J Mol Sci. 2020 Dec 8;21(24):9345. doi: 10.3390/ijms21249345. Int J Mol Sci. 2020. PMID: 33302435 Free PMC article.
Monosomy-3 in uveal melanoma (UM) cells increases the risk of fatal metastases. The gene encoding the low-affinity glucose transporter GLUT2 resides on chromosome 3q26.2. ...
Monosomy-3 in uveal melanoma (UM) cells increases the risk of fatal metastases. The gene encoding the low-affinity glucose transporte …
Quercetin Impairs the Growth of Uveal Melanoma Cells by Interfering with Glucose Uptake and Metabolism.
Tura A, Herfs V, Maaßen T, Zuo H, Vardanyan S, Prasuhn M, Ranjbar M, Kakkassery V, Grisanti S. Tura A, et al. Int J Mol Sci. 2024 Apr 12;25(8):4292. doi: 10.3390/ijms25084292. Int J Mol Sci. 2024. PMID: 38673877 Free PMC article.
Monosomy 3 in uveal melanoma (UM) increases the risk of lethal metastases, mainly in the liver, which serves as the major site for the storage of excessive glucose and the metabolization of the dietary flavonoid quercetin. ...
Monosomy 3 in uveal melanoma (UM) increases the risk of lethal metastases, mainly in the liver, which serves as the major site for th …
Loss of MAPK-activated protein kinase 2 enables potent dendritic cell-driven anti-tumour T cell response.
Soukup K, Halfmann A, Dillinger B, Poyer F, Martin K, Blauensteiner B, Kauer M, Kuttke M, Schabbauer G, Dohnal AM. Soukup K, et al. Sci Rep. 2017 Sep 18;7(1):11746. doi: 10.1038/s41598-017-12208-7. Sci Rep. 2017. PMID: 28924177 Free PMC article.
Using a cell type-specific murine knock-out model, we have identified MAPK-activated protein kinase 2 (MK2) as a major guardian of a suppressive DC phenotype in the melanoma tumour microenvironment. MK2 deletion in CD11c(+) cells led to an expansion of stimulatory CD103(+) …
Using a cell type-specific murine knock-out model, we have identified MAPK-activated protein kinase 2 (MK2) as a major guardian of a suppres …
Aripiprazole Cytotoxicity Coincides with Activation of the Unfolded Protein Response in Human Hepatic Cells.
Forno F, Maatuf Y, Boukeileh S, Dipta P, Mahameed M, Darawshi O, Ferreira V, Rada P, García-Martinez I, Gross E, Priel A, Valverde ÁM, Tirosh B. Forno F, et al. J Pharmacol Exp Ther. 2020 Sep;374(3):452-461. doi: 10.1124/jpet.119.264481. Epub 2020 Jun 17. J Pharmacol Exp Ther. 2020. PMID: 32554435 Free article.
This occurred at low micromolar concentrations and to variable intensities in different cell types, such as hepatocellular carcinoma, melanoma, and glioblastoma. Mechanistically, Aripiprazole caused depletion of ER calcium, leading to activation of inositol-requiring enzym …
This occurred at low micromolar concentrations and to variable intensities in different cell types, such as hepatocellular carcinoma, mel …
C-MYC and C-FOS expression changes and cellular aspects of the photodynamic reaction with photosensitizers TMPyP and ClAlPcS2.
Pizova K, Bajgar R, Fillerova R, Kriegova E, Cenklova V, Langova K, Konecny P, Kolarova H. Pizova K, et al. J Photochem Photobiol B. 2015 Jan;142:186-96. doi: 10.1016/j.jphotobiol.2014.12.003. Epub 2014 Dec 9. J Photochem Photobiol B. 2015. PMID: 25545333
We determined cell viability, reactive oxygen species (ROS) generation and changes in expression levels of two important early response genes, C-MYC and C-FOS, on tumor MCF7 (human breast adenocarcinoma) and G361 (human melanoma) cell lines and non-tumor BJ cell line (huma …
We determined cell viability, reactive oxygen species (ROS) generation and changes in expression levels of two important early response gene …