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Dynamic content exchange between liprotides.
Frislev HS, Jakobsen SCL, Frank SA, Otzen DE. Frislev HS, et al. Biophys Chem. 2018 Feb;233:13-18. doi: 10.1016/j.bpc.2017.11.006. Epub 2017 Dec 5. Biophys Chem. 2018. PMID: 29227791
Liprotides, composed of alpha-lactalbumin (aLA) and oleic acid (OA), are similar in components and cytotoxicity to the original HAMLET protein-fatty acid complex. Liprotides composed of aLA and OA kill tumor cells by transferring the OA component to, and thus destabilizing …
Liprotides, composed of alpha-lactalbumin (aLA) and oleic acid (OA), are similar in components and cytotoxicity to the original HAMLET prote …
Bi-specific TCR-anti CD3 redirected T-cell targeting of NY-ESO-1- and LAGE-1-positive tumors.
McCormack E, Adams KJ, Hassan NJ, Kotian A, Lissin NM, Sami M, Mujić M, Osdal T, Gjertsen BT, Baker D, Powlesland AS, Aleksic M, Vuidepot A, Morteau O, Sutton DH, June CH, Kalos M, Ashfield R, Jakobsen BK. McCormack E, et al. Cancer Immunol Immunother. 2013 Apr;62(4):773-85. doi: 10.1007/s00262-012-1384-4. Epub 2012 Dec 22. Cancer Immunol Immunother. 2013. PMID: 23263452 Free PMC article.
Here, we present data to describe the specificity and anti-tumor activity of a bifunctional ImmTAC, comprising a soluble, high-affinity T-cell receptor (TCR) specific for NY-ESO-1157-165 fused to an anti-CD3 scFv. This reagent, ImmTAC-NYE, is shown to kill HLA-A2, antigen- …
Here, we present data to describe the specificity and anti-tumor activity of a bifunctional ImmTAC, comprising a soluble, high-affinity T-ce …
Pharmacokinetics and Pharmacodynamics of Fosfomycin and Its Activity against Extended-Spectrum-β-Lactamase-, Plasmid-Mediated AmpC-, and Carbapenemase-Producing Escherichia coli in a Murine Urinary Tract Infection Model.
Zykov IN, Samuelsen Ø, Jakobsen L, Småbrekke L, Andersson DI, Sundsfjord A, Frimodt-Møller N. Zykov IN, et al. Antimicrob Agents Chemother. 2018 May 25;62(6):e02560-17. doi: 10.1128/AAC.02560-17. Print 2018 Jun. Antimicrob Agents Chemother. 2018. PMID: 29581117 Free PMC article.
Histone Deacetylase Inhibitors Enhance CD4 T Cell Susceptibility to NK Cell Killing but Reduce NK Cell Function.
Pace M, Williams J, Kurioka A, Gerry AB, Jakobsen B, Klenerman P, Nwokolo N, Fox J, Fidler S, Frater J; CHERUB Investigators. Pace M, et al. PLoS Pathog. 2016 Aug 16;12(8):e1005782. doi: 10.1371/journal.ppat.1005782. eCollection 2016 Aug. PLoS Pathog. 2016. PMID: 27529554 Free PMC article.
These data suggest that following HDACi-induced HLA class I down-regulation NK cells kill HIV-1-infected cells, although HDACi-mediated NK cell inhibition may negate this effect. ...
These data suggest that following HDACi-induced HLA class I down-regulation NK cells kill HIV-1-infected cells, although HDACi-mediat …
Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.
Bulek AM, Cole DK, Skowera A, Dolton G, Gras S, Madura F, Fuller A, Miles JJ, Gostick E, Price DA, Drijfhout JW, Knight RR, Huang GC, Lissin N, Molloy PE, Wooldridge L, Jakobsen BK, Rossjohn J, Peakman M, Rizkallah PJ, Sewell AK. Bulek AM, et al. Nat Immunol. 2012 Jan 15;13(3):283-9. doi: 10.1038/ni.2206. Nat Immunol. 2012. PMID: 22245737 Free PMC article.
The structural characteristics of the engagement of major histocompatibility complex (MHC) class II-restricted self antigens by autoreactive T cell antigen receptors (TCRs) is established, but how autoimmune TCRs interact with complexes of self peptide and MHC class I has been un …
The structural characteristics of the engagement of major histocompatibility complex (MHC) class II-restricted self antigens by autoreactive …
Impact of low-level fluoroquinolone resistance genes qnrA1, qnrB19 and qnrS1 on ciprofloxacin treatment of isogenic Escherichia coli strains in a murine urinary tract infection model.
Jakobsen L, Cattoir V, Jensen KS, Hammerum AM, Nordmann P, Frimodt-Møller N. Jakobsen L, et al. J Antimicrob Chemother. 2012 Oct;67(10):2438-44. doi: 10.1093/jac/dks224. Epub 2012 Jun 8. J Antimicrob Chemother. 2012. PMID: 22685162
METHODS: From a wild-type (wt) Escherichia coli UTI isolate, three isogenic strains were constructed carrying low-level ciprofloxacin resistance genes qnrA1, qnrB19 or qnrS1 (ciprofloxacin MIC range: 0.19-0.38 mg/L). Time-kill studies were performed for all four isogenic s …
METHODS: From a wild-type (wt) Escherichia coli UTI isolate, three isogenic strains were constructed carrying low-level ciprofloxacin resist …
Heteroduplex mobility assay-guided sequence discovery: elucidation of the small subunit (18S) rDNA sequences of Pfiesteria piscicida and related dinoflagellates from complex algal culture and environmental sample DNA pools.
Oldach DW, Delwiche CF, Jakobsen KS, Tengs T, Brown EG, Kempton JW, Schaefer EF, Bowers HA, Glasgow HB Jr, Burkholder JM, Steidinger KA, Rublee PA. Oldach DW, et al. Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4303-8. doi: 10.1073/pnas.97.8.4303. Proc Natl Acad Sci U S A. 2000. PMID: 10760297 Free PMC article.
Specific PCR assays for P. piscicida and other estuarine heterotrophic dinoflagellates were developed, permitting their detection in algal cultures and in estuarine water samples collected during fish kill and fish lesion events. These tools should enhance efforts to chara …
Specific PCR assays for P. piscicida and other estuarine heterotrophic dinoflagellates were developed, permitting their detection in algal c …
Mobile autopsy teams in the investigation of war crimes in Kosovo 1999.
Sprogøe-Jakobsen S, Eriksson A, Hougen HP, Knudsen PJ, Leth P, Lynnerup N. Sprogøe-Jakobsen S, et al. J Forensic Sci. 2001 Nov;46(6):1392-6. J Forensic Sci. 2001. PMID: 11714150
The most common cause of death was gun shot wounds and the most common manner of death was homicide....
The most common cause of death was gun shot wounds and the most common manner of death was homicide....