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2020 1
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Succination inactivates gasdermin D and blocks pyroptosis.
Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Humphries F, et al. Science. 2020 Sep 25;369(6511):1633-1637. doi: 10.1126/science.abb9818. Epub 2020 Aug 20. Science. 2020. PMID: 32820063 Free PMC article.
Dysbiosis exacerbates colitis by promoting ubiquitination and accumulation of the innate immune adaptor STING in myeloid cells.
Shmuel-Galia L, Humphries F, Lei X, Ceglia S, Wilson R, Jiang Z, Ketelut-Carneiro N, Foley SE, Pechhold S, Houghton J, Muneeruddin K, Shaffer SA, McCormick BA, Reboldi A, Ward D, Marshak-Rothstein A, Fitzgerald KA. Shmuel-Galia L, et al. Immunity. 2021 Jun 8;54(6):1137-1153.e8. doi: 10.1016/j.immuni.2021.05.008. Epub 2021 May 28. Immunity. 2021. PMID: 34051146 Free PMC article.
The 2023 Impact of Inflammatory Bowel Disease in Canada: Special Populations-IBD in Seniors.
Shaffer SR, Kuenzig ME, Windsor JW, Bitton A, Jones JL, Lee K, Murthy SK, Targownik LE, Peña-Sánchez JN, Rohatinsky N, Ghandeharian S, Tandon P, St-Pierre J, Natt N, Davis T, Weinstein J, Im JHB, Benchimol EI, Kaplan GG, Goddard Q, Gorospe J, Bergevin M, Silver K, Bowles D, Stewart M, Pearlstein M, Dawson EH, Bernstein CN. Shaffer SR, et al. J Can Assoc Gastroenterol. 2023 Sep 5;6(Suppl 2):S45-S54. doi: 10.1093/jcag/gwad013. eCollection 2023 Sep. J Can Assoc Gastroenterol. 2023. PMID: 37674503 Free PMC article. Review.