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ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models.
Cramer PE, Cirrito JR, Wesson DW, Lee CY, Karlo JC, Zinn AE, Casali BT, Restivo JL, Goebel WD, James MJ, Brunden KR, Wilson DA, Landreth GE. Cramer PE, et al. Science. 2012 Mar 23;335(6075):1503-6. doi: 10.1126/science.1217697. Epub 2012 Feb 9. Science. 2012. PMID: 22323736 Free PMC article.
Oral administration of the RXR agonist bexarotene to a mouse model of AD resulted in enhanced clearance of soluble Abeta within hours in an apoE-dependent manner. Abeta plaque area was reduced more than 50% within just 72 hours. ...
Oral administration of the RXR agonist bexarotene to a mouse model of AD resulted in enhanced clearance of soluble Abeta within hours …
Distinguishing infected from noninfected abdominal fluid collections after surgery: an imaging, clinical, and laboratory-based scoring system.
Gnannt R, Fischer MA, Baechler T, Clavien PA, Karlo C, Seifert B, Lesurtel M, Alkadhi H. Gnannt R, et al. Invest Radiol. 2015 Jan;50(1):17-23. doi: 10.1097/RLI.0000000000000090. Invest Radiol. 2015. PMID: 25198832 Free article.
MATERIALS AND METHODS: The score developmental cohort included 100 consecutive patients (69 men, 31 women; mean age, 58 17 years) who underwent portal-venous phase CT within 24 hours before CT-guided intervention of postoperative abdominal fluid collections. ...
MATERIALS AND METHODS: The score developmental cohort included 100 consecutive patients (69 men, 31 women; mean age, 58 17 years) who underw …