Profiling interactions of vaborbactam with metallo-β-lactamases.
Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J.
Langley GW, et al.
Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17.
Bioorg Med Chem Lett. 2019.
PMID: 31171422
Free PMC article.
Here we show that vaborbactam moderately inhibits metallo-beta-lactamases from all 3 subclasses (B1, B2 and B3), with a potency of around 20-100 fold below that by which it inhibits its current clinical targets, the Class A serine beta-lactamases. ...
Here we show that vaborbactam moderately inhibits metallo-beta-lactamases from all 3 subclasses (B1, B2 and B3), with a potency of around …