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Year Number of Results
1984 1
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2000 1
2001 1
2003 1
2004 1
2005 2
2006 1
2007 10
2008 5
2009 1
2010 5
2011 7
2012 7
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2014 4
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72 results

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Page 1
A Review of the Pharmacological Efficacy and Safety of Licorice Root from Corroborative Clinical Trial Findings.
Kwon YJ, Son DH, Chung TH, Lee YJ. Kwon YJ, et al. J Med Food. 2020 Jan;23(1):12-20. doi: 10.1089/jmf.2019.4459. Epub 2019 Dec 23. J Med Food. 2020. PMID: 31874059 Review.
Since ancient times, licorice, the root of Glycyrrhiza glabra, has been known to have a wide spectrum of therapeutic effects. Glycyrrhizin is cleaved to glycyrrhizic acid, which is subsequently converted to glycyrrhetic acid by human intestinal microflora. Glycyrrhe …
Since ancient times, licorice, the root of Glycyrrhiza glabra, has been known to have a wide spectrum of therapeutic effects. Glycyrrhizin i …
Natural compound glycyrrhetinic acid protects against doxorubicin-induced cardiotoxicity by activating the Nrf2/HO-1 signaling pathway.
Cheng Y, Wu X, Nie X, Wu Y, Zhang C, Lee SM, Lv K, Leung GP, Fu C, Zhang J, Li J. Cheng Y, et al. Phytomedicine. 2022 Nov;106:154407. doi: 10.1016/j.phymed.2022.154407. Epub 2022 Sep 5. Phytomedicine. 2022. PMID: 36070662
Nevertheless, the clinical outcomes of Dox-based therapies are severely hampered due to the significant cardiotoxicity. Glycyrrhetinic acid (GA) is the major biologically active compound of licorice, one of the most well-known food additives and medicinal plants in …
Nevertheless, the clinical outcomes of Dox-based therapies are severely hampered due to the significant cardiotoxicity. Glycyrrhetinic …
Glycyrrhetinic acid suppresses breast cancer metastasis by inhibiting M2-like macrophage polarization via activating JNK1/2 signaling.
Cheng Y, Zhong X, Nie X, Gu H, Wu X, Li R, Wu Y, Lv K, Leung GP, Fu C, Lee SM, Zhang J, Li J. Cheng Y, et al. Phytomedicine. 2023 Jun;114:154757. doi: 10.1016/j.phymed.2023.154757. Epub 2023 Mar 12. Phytomedicine. 2023. PMID: 37011418
Tumor-associated macrophages (TAMs) have been considered as potential targets for treating breast cancer metastasis because they promote tumor growth and development. Glycyrrhetinic acid (GA) is one of the most important phytochemicals of licorice which has shown pr …
Tumor-associated macrophages (TAMs) have been considered as potential targets for treating breast cancer metastasis because they promote tum …
18beta-glycyrrhetinic acid induces UDP-glucuronosyltransferase in rats.
Lee KW, Ho WS. Lee KW, et al. Protein Pept Lett. 2013 Dec;20(12):1360-4. doi: 10.2174/092986652012131112124033. Protein Pept Lett. 2013. PMID: 24261979 Review.
In this study, rats were orally administered with 18beta-glycyrrhetinic acid (GA) for four weeks before rats were sacrificed. The mRNA was extracted from the liver and cDNA was prepared by reverse transcription method. ...
In this study, rats were orally administered with 18beta-glycyrrhetinic acid (GA) for four weeks before rats were sacrificed. …
Glycyrrhetinic Acid-Modified Silicon Phthalocyanine for Liver Cancer-Targeted Photodynamic Therapy.
Kim J, Lee S, Na K. Kim J, et al. Biomacromolecules. 2021 Feb 8;22(2):811-822. doi: 10.1021/acs.biomac.0c01550. Epub 2020 Dec 28. Biomacromolecules. 2021. PMID: 33356155
To supplement shortcomings of existing treatments and enhance the therapeutic effect for liver cancer, a novel photosensitizer is designed using silicon phthalocyanine (SiPC) and a unique targeting moiety, glycyrrhetinic acid (GA). The SiPC is modified with a hydrop …
To supplement shortcomings of existing treatments and enhance the therapeutic effect for liver cancer, a novel photosensitizer is designed u …
Ethanol Extract of Licorice Alleviates HFD-Induced Liver Fat Accumulation in Association with Modulation of Gut Microbiota and Intestinal Metabolites in Obesity Mice.
Liu F, Tang X, Mao B, Zhang Q, Zhao J, Cui S, Chen W. Liu F, et al. Nutrients. 2022 Oct 8;14(19):4180. doi: 10.3390/nu14194180. Nutrients. 2022. PMID: 36235833 Free PMC article.
We hypothesized that the involvement of intestinal flora may be a key link in licorice ethanol extract (LEE)-induced health benefits. The aim of this study was to investigate whether LEE improves hepatic lipid accumulation in obese mice fed a high-fat diet (HFD) and …
We hypothesized that the involvement of intestinal flora may be a key link in licorice ethanol extract (LEE)-induced health benefits. …
Dual-Ligand-Functionalized Liposomes Based on Glycyrrhetinic Acid and cRGD for Hepatocellular Carcinoma Targeting and Therapy.
Qiu M, Wang J, Bai J, Li X, Tian C, Liu Z, Zheng C, Clark AR, Cheng X, Liao X, Wu S, Lee RJ, Zhou X. Qiu M, et al. Mol Pharm. 2023 Apr 3;20(4):1951-1963. doi: 10.1021/acs.molpharmaceut.2c00842. Epub 2023 Mar 23. Mol Pharm. 2023. PMID: 36952242
However, the high toxicity and poor specificity of chemotherapeutic drugs have limited their clinical application. In this study, dual-ligand liposomes modified with glycyrrhetinic acid (GA) and cyclic arginine-glycine-aspartic acid (cRGD) (GA/cRGD-LP) were d …
However, the high toxicity and poor specificity of chemotherapeutic drugs have limited their clinical application. In this study, dual-ligan …
Comparative effect of vitamin D3 and carbenoxolone treatments in metabolic syndrome rats.
Saleh N, Seif AA, Bahaa I, Abdel-Hady EA. Saleh N, et al. Can J Physiol Pharmacol. 2022 May;100(5):412-421. doi: 10.1139/cjpp-2021-0400. Epub 2021 Dec 2. Can J Physiol Pharmacol. 2022. PMID: 34855519
Compared with untreated MetS, vitamin D3- and carbenoxolone-treated rats showed significant reduction in blood pressure, body mass index, Lee index, waist circumference, retroperitoneal fat, and improvement of dyslipidemia. ...
Compared with untreated MetS, vitamin D3- and carbenoxolone-treated rats showed significant reduction in blood pressure, body mass index, …
Cortisol induces follicle regression, while FSH prevents cortisol-induced follicle regression in pigs.
Nakanishi T, Okamoto A, Ikeda M, Tate S, Sumita M, Kawamoto R, Tonai S, Lee JY, Shimada M, Yamashita Y. Nakanishi T, et al. Mol Hum Reprod. 2021 Jul 1;27(7):gaab038. doi: 10.1093/molehr/gaab038. Mol Hum Reprod. 2021. PMID: 34057472
Cortisol-induced CYP11B1 and CYP21A2 expression, whereas FSH-induced HSD11B2 mRNA expression in VF granulosa cells in the presence of cortisol. Furthermore, an addition of 18beta-glycyrrhetinic acid (18-GA; a HSD17B2 inhibitor) to cortisol and FSH-containing medium …
Cortisol-induced CYP11B1 and CYP21A2 expression, whereas FSH-induced HSD11B2 mRNA expression in VF granulosa cells in the presence of cortis …
72 results