FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis.
FASEB J. 2018 Feb;32(2):1099-1107. doi: 10.1096/fj.201700721R. Epub 2018 Jan 3.
FASEB J. 2018.
PMID: 29070586
Here, we show that FAK controls the nuclear translocation and activation of YAP in response to mechanical activation and submit that the YAP-dependent process of durotaxis requires a cell with an asymmetric distribution of active and inactive FAK molecules.-Lachowski, D., …
Here, we show that FAK controls the nuclear translocation and activation of YAP in response to mechanical activation and submit that the YAP …