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Multicomponent intervention to prevent mobility disability in frail older adults: randomised controlled trial (SPRINTT project).
Bernabei R, Landi F, Calvani R, Cesari M, Del Signore S, Anker SD, Bejuit R, Bordes P, Cherubini A, Cruz-Jentoft AJ, Di Bari M, Friede T, Gorostiaga Ayestarán C, Goyeau H, Jónsson PV, Kashiwa M, Lattanzio F, Maggio M, Mariotti L, Miller RR, Rodriguez-Mañas L, Roller-Wirnsberger R, Rýznarová I, Scholpp J, Schols AMWJ, Sieber CC, Sinclair AJ, Skalska A, Strandberg T, Tchalla A, Topinková E, Tosato M, Vellas B, von Haehling S, Pahor M, Roubenoff R, Marzetti E; SPRINTT consortium. Bernabei R, et al. BMJ. 2022 May 11;377:e068788. doi: 10.1136/bmj-2021-068788. BMJ. 2022. PMID: 35545258 Free PMC article. Clinical Trial.
The decline in handgrip strength at 24 months was smaller in women assigned to the multicomponent intervention than to control (0.9 kg, 95% confidence interval 0.1 to 1.6 kg; P=0.028). Women in the multicomponent intervention arm lost 0.24 kg and 0.49 kg less appendicular …
The decline in handgrip strength at 24 months was smaller in women assigned to the multicomponent intervention than to control (0.9 kg, 95% …
Wide local excision, Mohs micrographic surgery, and reconstructive options for treatment of dermatofibrosarcoma protuberans of the breast: A retrospective case series from Mayo Clinic.
Saifuddin H, Yan M, Jakub J, Martinez-Jorge J, Roenigk R, Vijayasekaran A. Saifuddin H, et al. World J Surg Oncol. 2023 May 6;21(1):141. doi: 10.1186/s12957-023-03022-9. World J Surg Oncol. 2023. PMID: 37147611 Free PMC article.
Median follow-up for the patients without recurrence was 5.0 years, with two patients in MMS cohort lost to follow-up. Five-year overall survival was 100%. CONCLUSIONS: MMS and WLE are both viable surgical options for managing DFSP of the breast. ...
Median follow-up for the patients without recurrence was 5.0 years, with two patients in MMS cohort lost to follow-up. Five-year over …
Gas Phase Stability of Protein Ions in a Cyclic Ion Mobility Spectrometry Traveling Wave Device.
Eldrid C, Ujma J, Kalfas S, Tomczyk N, Giles K, Morris M, Thalassinos K. Eldrid C, et al. Anal Chem. 2019 Jun 18;91(12):7554-7561. doi: 10.1021/acs.analchem.8b05641. Epub 2019 Jun 5. Anal Chem. 2019. PMID: 31117399 Free PMC article.
This, however, increases the time that protein ions spend in the gas phase and previous experiments have shown that the initial conformations of small proteins can be lost within tens of milliseconds. Here, we report on investigations of protein ion stability using a multi …
This, however, increases the time that protein ions spend in the gas phase and previous experiments have shown that the initial conformation …
Whole Liver Palliative Radiotherapy for Patients with Massive Liver Metastases.
Edyta WR, Jakub L, Jerzy W. Edyta WR, et al. Asian Pac J Cancer Prev. 2015;16(15):6381-4. doi: 10.7314/apjcp.2015.16.15.6381. Asian Pac J Cancer Prev. 2015. PMID: 26434846 Free article.
MATERIALS AND METHODS: Twenty-seven patients with liver metastases were enrolled and received targeted whole liver irradiation consisting of mean 1, 8 Gy in five to twelve fractions to a total mean dose 17 Gy. Symptoms at baseline were hepatic pain (26 patients), lost of w …
MATERIALS AND METHODS: Twenty-seven patients with liver metastases were enrolled and received targeted whole liver irradiation consisting of …
Antioxidant defense in quiescent cells determines selectivity of electron transport chain inhibition-induced cell death.
Blecha J, Novais SM, Rohlenova K, Novotna E, Lettlova S, Schmitt S, Zischka H, Neuzil J, Rohlena J. Blecha J, et al. Free Radic Biol Med. 2017 Nov;112:253-266. doi: 10.1016/j.freeradbiomed.2017.07.033. Epub 2017 Jul 31. Free Radic Biol Med. 2017. PMID: 28774815
This is related to the inability of quiescent cells to compensate for the lost mitochondrial ATP production by the upregulation of glucose uptake. ...
This is related to the inability of quiescent cells to compensate for the lost mitochondrial ATP production by the upregulation of gl …
Experimental addition of nitrogen to a whole forest ecosystem at Gårdsjön, Sweden (NITREX): Nitrate leaching during 26 years of treatment.
Moldan F, Jutterström SEA, Hruška J, Wright RF. Moldan F, et al. Environ Pollut. 2018 Nov;242(Pt A):367-374. doi: 10.1016/j.envpol.2018.06.093. Epub 2018 Jul 2. Environ Pollut. 2018. PMID: 29990944
Over the first 10 years of treatment there was an increasing amount of nitrate (NO(3)(-)) and to a lesser extent ammonium (NH(4)(+)) lost in runoff, but then N leaching stabilised, and for the subsequent 16 years the fraction of N added lost in runoff remained at 9% …
Over the first 10 years of treatment there was an increasing amount of nitrate (NO(3)(-)) and to a lesser extent ammonium (NH(4)(+)) lost …
Comparative Analysis of Four Calypogeia Species Revealed Unexpected Change in Evolutionarily-Stable Liverwort Mitogenomes.
Ślipiko M, Myszczyński K, Buczkowska-Chmielewska K, Bączkiewicz A, Szczecińska M, Sawicki J. Ślipiko M, et al. Genes (Basel). 2017 Dec 19;8(12):395. doi: 10.3390/genes8120395. Genes (Basel). 2017. PMID: 29257096 Free PMC article.
Such differences involve unexpected structural changes in the two genes, cox1 and atp1, which have lost three and two introns, respectively. The group I introns in the cox1 gene are proposed to have been lost by two-step localized retroprocessing, whereas one-step r …
Such differences involve unexpected structural changes in the two genes, cox1 and atp1, which have lost three and two introns, respec …
Comparative effectiveness of 8 versus 12 weeks of Ombitasvir/Paritaprevir/ritonavir and Dasabuvir in treatment-naïve patients infected with HCV genotype 1b with non-advanced hepatic fibrosis.
Zarębska-Michaluk D, Piekarska A, Jaroszewicz J, Klapaczyński J, Mazur W, Krygier R, Belica-Wdowik T, Baka-Ćwierz B, Janczewska E, Pabjan P, Dobracka B, Lorenc B, Tudrujek-Zdunek M, Tomasiewicz K, Sitko M, Garlicki A, Czauż-Andrzejuk A, Citko J, Dybowska D, Halota W, Pawłowska M, Laurans Ł, Deroń Z, Buczyńska I, Simon K, Białkowska J, Tronina O, Flisiak R. Zarębska-Michaluk D, et al. Adv Med Sci. 2020 Mar;65(1):12-17. doi: 10.1016/j.advms.2019.09.002. Epub 2019 Dec 13. Adv Med Sci. 2020. PMID: 31841821 Free article.
SVR was achieved in 186 (94%) patients treated for 8 weeks and 558 (97%) for 12 weeks (p = 0.07). After exclusion of lost to follow-up patients, sustained virological response (SVR) rate reached 95% and 99%, respectively (p = 0.01). ...
SVR was achieved in 186 (94%) patients treated for 8 weeks and 558 (97%) for 12 weeks (p = 0.07). After exclusion of lost to follow-u …