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Yap Regulates Muller Glia Reprogramming in Damaged Zebrafish Retinas.
Lourenço R, Brandão AS, Borbinha J, Gorgulho R, Jacinto A. Lourenço R, et al. Front Cell Dev Biol. 2021 Sep 20;9:667796. doi: 10.3389/fcell.2021.667796. eCollection 2021. Front Cell Dev Biol. 2021. PMID: 34616723 Free PMC article.
Here, we show that Yap is required in Muller glia to engage their response to a lesion by regulating their cell cycle reentry and progenitor cell formation, contributing to the differentiation of new photoreceptors. We propose that this regulation is accomplished through a …
Here, we show that Yap is required in Muller glia to engage their response to a lesion by regulating their cell cycle reentry and pro …
Yap induces osteoblast differentiation by modulating Bmp signalling during zebrafish caudal fin regeneration.
Brandão AS, Bensimon-Brito A, Lourenço R, Borbinha J, Soares AR, Mateus R, Jacinto A. Brandão AS, et al. J Cell Sci. 2019 Nov 14;132(22):jcs231993. doi: 10.1242/jcs.231993. J Cell Sci. 2019. PMID: 31636113
Here, we use zebrafish caudal fin regeneration as a model to clarify how the Hippo pathway regulates de novo bone formation and osteoblast differentiation. We demonstrate that Yap inhibition leads to accumulation of osteoprogenitors and prevents osteoblast differentiation …
Here, we use zebrafish caudal fin regeneration as a model to clarify how the Hippo pathway regulates de novo bone formation and osteoblast d …
Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration.
Mateus R, Lourenço R, Fang Y, Brito G, Farinho A, Valério F, Jacinto A. Mateus R, et al. Development. 2015 Aug 15;142(16):2752-63. doi: 10.1242/dev.119701. Epub 2015 Jul 24. Development. 2015. PMID: 26209644 Free PMC article.
However, how this is established and regulated is not well understood. Here, we report that Yap, the Hippo pathway effector, is a chief player in this process: functionally manipulating Yap during regeneration dramatically affects cell proliferation and expression o …
However, how this is established and regulated is not well understood. Here, we report that Yap, the Hippo pathway effector, is a chi …