Catecholamine induces Kupffer cell apoptosis via growth differentiation factor 15 in alcohol-associated liver disease.
Kim HH, Shim YR, Choi SE, Kim MH, Lee G, You HJ, Choi WM, Yang K, Ryu T, Kim K, Kim MJ, Woo C, Chung KPS, Hong SH, Eun HS, Kim SH, Ko G, Park JE, Gao B, Kim W, Jeong WI.
Kim HH, et al.
Exp Mol Med. 2023 Jan;55(1):158-170. doi: 10.1038/s12276-022-00921-x. Epub 2023 Jan 11.
Exp Mol Med. 2023.
PMID: 36631664
Free PMC article.
Single-cell RNA sequencing of KCs confirmed the elevated expression of Adrb2 and apoptotic genes after chronic ethanol intake. Genetic ablation of Adrb2 or hepatic Gdf15 robustly decreased the number of apoptotic KCs near perivenous areas, exacerbating alcohol-associated i …
Single-cell RNA sequencing of KCs confirmed the elevated expression of Adrb2 and apoptotic genes after chronic ethanol intake. Geneti …