One-pot one-step deracemization of amines using ω-transaminases

Chem Commun (Camb). 2013 Oct 7;49(77):8629-31. doi: 10.1039/c3cc43348j.

Abstract

In this study, we developed a one-pot one-step deracemization method for the production of various enantiomerically pure amines using two opposite enantioselective ω-TAs. Using this method, various aromatic amines were successfully converted to their (R)-forms (>99%) with good conversion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bacteria / enzymology*
  • Comamonadaceae / enzymology
  • Mycobacterium / enzymology
  • Neosartorya / enzymology*
  • Phenethylamines / chemistry*
  • Phenethylamines / metabolism*
  • Stereoisomerism
  • Transaminases / metabolism*
  • Vibrio / enzymology

Substances

  • Phenethylamines
  • Transaminases
  • 1-phenethylamine