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Year Number of Results
1992 1
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1999 1
2000 3
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2004 4
2005 5
2006 3
2007 2
2008 1
2009 3
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2011 6
2012 5
2013 4
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166 results

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Page 1
Stem cell-homing hydrogel-based miR-29b-5p delivery promotes cartilage regeneration by suppressing senescence in an osteoarthritis rat model.
Zhu J, Yang S, Qi Y, Gong Z, Zhang H, Liang K, Shen P, Huang YY, Zhang Z, Ye W, Yue L, Fan S, Shen S, Mikos AG, Wang X, Fang X. Zhu J, et al. Sci Adv. 2022 Apr;8(13):eabk0011. doi: 10.1126/sciadv.abk0011. Epub 2022 Mar 30. Sci Adv. 2022. PMID: 35353555 Free PMC article.
An injectable bioactive self-assembling peptide nanofiber hydrogel was applied to deliver agomir-29b-5p, which was functionalized by conjugating a stem cell-homing peptide SKPPGTSS for endogenous synovial stem cell recruitment simultaneously. ...
An injectable bioactive self-assembling peptide nanofiber hydrogel was applied to deliver agomir-29b-5p, which was functionalized by conjuga …
TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal.
Li Y, Xue M, Deng X, Dong L, Nguyen LXT, Ren L, Han L, Li C, Xue J, Zhao Z, Li W, Qing Y, Shen C, Tan B, Chen Z, Leung K, Wang K, Swaminathan S, Li L, Wunderlich M, Mulloy JC, Li X, Chen H, Zhang B, Horne D, Rosen ST, Marcucci G, Xu M, Li Z, Wei M, Tian J, Shen B, Su R, Chen J. Li Y, et al. Cell Stem Cell. 2023 Aug 3;30(8):1072-1090.e10. doi: 10.1016/j.stem.2023.07.001. Cell Stem Cell. 2023. PMID: 37541212
Here, we show that Tet2 deficiency significantly facilitates leukemogenesis in various AML models (mediated by aggressive or less aggressive mutations) through promoting homing of LSCs into bone marrow (BM) niche to increase their self-renewal/proliferation. ...Collectivel …
Here, we show that Tet2 deficiency significantly facilitates leukemogenesis in various AML models (mediated by aggressive or less aggressive …
Functional Dental Pulp Regeneration: Basic Research and Clinical Translation.
Xie Z, Shen Z, Zhan P, Yang J, Huang Q, Huang S, Chen L, Lin Z. Xie Z, et al. Int J Mol Sci. 2021 Aug 20;22(16):8991. doi: 10.3390/ijms22168991. Int J Mol Sci. 2021. PMID: 34445703 Free PMC article. Review.
Since the successful isolation and characterisation of dental pulp stem cells (DPSCs) and other applicable dental mesenchymal stem cells, basic research and preclinical exploration of stem cell-mediated functional pulp regeneration via cell transplantation and cell homing …
Since the successful isolation and characterisation of dental pulp stem cells (DPSCs) and other applicable dental mesenchymal stem cells, ba …
Targeting regenerative exosomes to myocardial infarction using cardiac homing peptide.
Vandergriff A, Huang K, Shen D, Hu S, Hensley MT, Caranasos TG, Qian L, Cheng K. Vandergriff A, et al. Theranostics. 2018 Feb 14;8(7):1869-1878. doi: 10.7150/thno.20524. eCollection 2018. Theranostics. 2018. PMID: 29556361 Free PMC article.
Though effective in a research setting, this method is not clinically appealing due to its invasive nature. We propose the use of a targeting peptide, cardiac homing peptide (CHP), to target intravenously-infused exosomes to the infarcted heart. ...
Though effective in a research setting, this method is not clinically appealing due to its invasive nature. We propose the use of a targetin …
Tissue adaptation and clonal segregation of human memory T cells in barrier sites.
Poon MML, Caron DP, Wang Z, Wells SB, Chen D, Meng W, Szabo PA, Lam N, Kubota M, Matsumoto R, Rahman A, Luning Prak ET, Shen Y, Sims PA, Farber DL. Poon MML, et al. Nat Immunol. 2023 Feb;24(2):309-319. doi: 10.1038/s41590-022-01395-9. Epub 2023 Jan 19. Nat Immunol. 2023. PMID: 36658238 Free PMC article.
By integrating single-cell protein and transcriptome profiling, we demonstrate that human barrier sites contain tissue-resident memory T (T(RM)) cells that exhibit site-adapted profiles for residency, homing and function distinct from circulating memory T cells. Incorporat …
By integrating single-cell protein and transcriptome profiling, we demonstrate that human barrier sites contain tissue-resident memory T (T( …
Engineered Exosomes With Ischemic Myocardium-Targeting Peptide for Targeted Therapy in Myocardial Infarction.
Wang X, Chen Y, Zhao Z, Meng Q, Yu Y, Sun J, Yang Z, Chen Y, Li J, Ma T, Liu H, Li Z, Yang J, Shen Z. Wang X, et al. J Am Heart Assoc. 2018 Aug 7;7(15):e008737. doi: 10.1161/JAHA.118.008737. J Am Heart Assoc. 2018. PMID: 30371236 Free PMC article.
However, targeting of exosomes to recipient cells precisely in vivo still remains a problem. Ligand fragments or homing peptides discovered by phage display and in vivo biopanning methods fused to the enriched molecules on the external part of exosomes have been exploited …
However, targeting of exosomes to recipient cells precisely in vivo still remains a problem. Ligand fragments or homing peptides disc …
Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.
Zhao Y, Zhang J, Cheng X, Huang W, Shen S, Wu S, Huang Y, Nie G, Wang H, Qiu W. Zhao Y, et al. Adv Sci (Weinh). 2023 Jul;10(20):e2300738. doi: 10.1002/advs.202300738. Epub 2023 May 12. Adv Sci (Weinh). 2023. PMID: 37170724 Free PMC article.
Human CD47 peptide and L-selectin targeting aptamer are modified on the nanoparticles encapsulated with FTY720 (clnFTY) for self-passivation and the targeting of L-selectin on lymphocytes, a homing receptor for T-cells entering LNs. Using this natural process, clnFTY nanop …
Human CD47 peptide and L-selectin targeting aptamer are modified on the nanoparticles encapsulated with FTY720 (clnFTY) for self-passivation …
Biomimetic nanoparticle synchronizing pyroptosis induction and mitophagy inhibition for anti-tumor therapy.
Deng Y, Jia F, Jiang P, Chen L, Xing L, Shen X, Li L, Huang Y. Deng Y, et al. Biomaterials. 2023 Oct;301:122293. doi: 10.1016/j.biomaterials.2023.122293. Epub 2023 Aug 24. Biomaterials. 2023. PMID: 37639978
Here, this study reports a nano-system camouflaged with hybrid membranes consisting of homologous cell membrane and corresponding mitochondrial membrane, which is used to deliver a drug complex Ca@GOx consisting of calcium phosphate and glucose oxidase. By taking advantage of the …
Here, this study reports a nano-system camouflaged with hybrid membranes consisting of homologous cell membrane and corresponding mitochondr …
Bone, microenvironment and hematopoiesis.
Shen Y, Nilsson SK. Shen Y, et al. Curr Opin Hematol. 2012 Jul;19(4):250-5. doi: 10.1097/MOH.0b013e328353c714. Curr Opin Hematol. 2012. PMID: 22504524 Review.
Research will lead to better manipulation of HSCs for mobilization, homing and hematopoietic reconstitution following injury or disease....
Research will lead to better manipulation of HSCs for mobilization, homing and hematopoietic reconstitution following injury or disea …
Monocytic MDSCs homing to thymus contribute to age-related CD8+ T cell tolerance of HBV.
Fang Z, Zhang Y, Zhu Z, Wang C, Hu Y, Peng X, Zhang D, Zhao J, Shi B, Shen Z, Wu M, Xu C, Chen J, Zhou X, Xie Y, Yu H, Zhang X, Li J, Hu Y, Kozlowski M, Bertoletti A, Yuan Z. Fang Z, et al. J Exp Med. 2022 Apr 4;219(4):e20211838. doi: 10.1084/jem.20211838. Epub 2022 Mar 7. J Exp Med. 2022. PMID: 35254403 Free PMC article.
Sequentially, the interaction between CCL25 and CCR9 mediated thymic homing of mMDSCs, which caused the cross-presentation, transferring of peripheral HBsAg into the thymic medulla, and then promoted death of HBsAg-specific CD8+ thymocytes. ...
Sequentially, the interaction between CCL25 and CCR9 mediated thymic homing of mMDSCs, which caused the cross-presentation, transferr …
166 results