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Hydrophobic Amino Acid Tryptophan Shows Promise as a Potential Absorption Enhancer for Oral Delivery of Biopharmaceuticals.
Kamei N, Tamiwa H, Miyata M, Haruna Y, Matsumura K, Ogino H, Hirano S, Higashiyama K, Takeda-Morishita M. Kamei N, et al. Pharmaceutics. 2018 Oct 10;10(4):182. doi: 10.3390/pharmaceutics10040182. Pharmaceutics. 2018. PMID: 30308982 Free PMC article.
Cationic arginine and hydrophobic tryptophan have been reported to be key component amino acids for cellular internalization of CPPs. We recently found that l-arginine could increase the oral delivery of insulin in its single amino acid form. Therefore, in the prese …
Cationic arginine and hydrophobic tryptophan have been reported to be key component amino acids for cellular internalization of CPPs. …
Improvement of the bitter taste of amino acids through the transpeptidation reaction of bacterial gamma-glutamyltranspeptidase.
Suzuki H, Kajimoto Y, Kumagai H. Suzuki H, et al. J Agric Food Chem. 2002 Jan 16;50(2):313-8. doi: 10.1021/jf010726u. J Agric Food Chem. 2002. PMID: 11782200
The tastes of several bitter amino acids and their gamma-glutamyl derivatives were compared. The bitterness of Phe, Val, Leu, and His was reduced, sourness was produced, and preferences were increased by gamma-glutamylization. Because the effect of gamma-glutamylization of …
The tastes of several bitter amino acids and their gamma-glutamyl derivatives were compared. The bitterness of Phe, Val, Leu, and His …
Gamma-glutamyl compounds and their enzymatic production using bacterial gamma-glutamyltranspeptidase.
Suzuki H, Yamada C, Kato K. Suzuki H, et al. Amino Acids. 2007;32(3):333-40. doi: 10.1007/s00726-006-0416-9. Epub 2006 Oct 13. Amino Acids. 2007. PMID: 17031476 Review.
Some amino acids and peptides, which have low solubility in water, become much more soluble following gamma-glutamylation. ...An efficient and simple method of producing various gamma-glutamyl compounds, especially gamma-glutamyl amino acids, using bacterial gamma-g …
Some amino acids and peptides, which have low solubility in water, become much more soluble following gamma-glutamylation. ...An effi …
Improvement of putrescine production through the arginine decarboxylase pathway in Escherichia coli K-12.
Thongbhubate K, Irie K, Sakai Y, Itoh A, Suzuki H. Thongbhubate K, et al. AMB Express. 2021 Dec 15;11(1):168. doi: 10.1186/s13568-021-01330-5. AMB Express. 2021. PMID: 34910273 Free PMC article.
N-Acetylglutamate (ArgA) synthase is subjected to feedback inhibition by arginine. Therefore, the 19th amino acid residue, Tyr, of argA was substituted with Cys to desensitize the feedback inhibition of arginine, resulting in improved putrescine production. ...
N-Acetylglutamate (ArgA) synthase is subjected to feedback inhibition by arginine. Therefore, the 19th amino acid residue, Tyr, of ar …
The Meningococcal Cysteine Transport System Plays a Crucial Role in Neisseria meningitidis Survival in Human Brain Microvascular Endothelial Cells.
Takahashi H, Watanabe H, Kim KS, Yokoyama S, Yanagisawa T. Takahashi H, et al. mBio. 2018 Dec 11;9(6):e02332-18. doi: 10.1128/mBio.02332-18. mBio. 2018. PMID: 30538184 Free PMC article.
Taking cysteine concentrations in human cells and other body fluids, including blood and cerebrospinal fluid, into consideration, the present results collectively suggest that the meningococcal CTS is crucial for the acquisition of cysteine from human cells and participates in me …
Taking cysteine concentrations in human cells and other body fluids, including blood and cerebrospinal fluid, into consideration, the presen …
A Novel Quorum-Quenching N-Acylhomoserine Lactone Acylase from Acidovorax sp. Strain MR-S7 Mediates Antibiotic Resistance.
Kusada H, Tamaki H, Kamagata Y, Hanada S, Kimura N. Kusada H, et al. Appl Environ Microbiol. 2017 Jun 16;83(13):e00080-17. doi: 10.1128/AEM.00080-17. Print 2017 Jul 1. Appl Environ Microbiol. 2017. PMID: 28455333 Free PMC article.
In addition, this enzyme was found to be capable of degrading a wide spectrum of beta-lactams (penicillin G, ampicillin, amoxicillin, carbenicillin, cephalexin, and cefadroxil) by deacylation, clearly indicating that MacQ is a bifunctional enzyme that confers both quorum quenchin …
In addition, this enzyme was found to be capable of degrading a wide spectrum of beta-lactams (penicillin G, ampicillin, amoxicillin, carben …
Development of an efficient enzymatic production of gamma-D-glutamyl-L-tryptophan (SCV-07), a prospective medicine for tuberculosis, with bacterial gamma-glutamyltranspeptidase.
Suzuki H, Kato K, Kumagai H. Suzuki H, et al. J Biotechnol. 2004 Aug 5;111(3):291-5. doi: 10.1016/j.jbiotec.2004.04.003. J Biotechnol. 2004. PMID: 15246665
Because gamma-D-glutamyl-L-tryptophan has several reactive groups in its molecule, consists of D- and L-amino acids, and is connected by gamma-glutamyl linkage, its chemical synthesis is complicated. ...
Because gamma-D-glutamyl-L-tryptophan has several reactive groups in its molecule, consists of D- and L-amino acids, and is connected …
16 results