Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells.
Lim EJ, Joung YH, Jung SM, Park SH, Park JH, Kim SY, Hwang TS, Hong DY, Chung SC, Ye SK, Moon ES, Park EU, Park T, Chung IM, Yang YM.
Lim EJ, et al.
Int J Oncol. 2010 May;36(5):1243-51. doi: 10.3892/ijo_00000608.
Int J Oncol. 2010.
PMID: 20372799
EMSA studies showed that STAT5 binding activity to the IGF-1 and cyclin D1 promoter was distinctly decreased by hemin in STAT5b-transfected COS-7 or MDA-MB 231 cells. IGF-1 gene expression was also decreased by hemin in mammary epithelial cells. ...These data indica …
EMSA studies showed that STAT5 binding activity to the IGF-1 and cyclin D1 promoter was distinctly decreased by hemin in STAT5b-trans …