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70 results

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Hemin enhances the cardioprotective effects of mesenchymal stem cell-derived exosomes against infarction via amelioration of cardiomyocyte senescence.
Zheng H, Liang X, Han Q, Shao Z, Zhang Y, Shi L, Hong Y, Li W, Mai C, Mo Q, Fu Q, Ma X, Lin F, Li M, Hu B, Li X, Zhang Y. Zheng H, et al. J Nanobiotechnology. 2021 Oct 21;19(1):332. doi: 10.1186/s12951-021-01077-y. J Nanobiotechnology. 2021. PMID: 34674708 Free PMC article.
This study aimed to investigate the therapeutic effects of EXO derived from hemin-pretreated MSCs (Hemin-MSC-EXO) in MI and explore the potential mechanisms. METHODS: MSC-EXO and Hemin-MSC-EXO were collected and characterized. MSC-EXO and Hemin-MSC-EXO …
This study aimed to investigate the therapeutic effects of EXO derived from hemin-pretreated MSCs (Hemin-MSC-EXO) in MI and ex …
Hemin enhances radiosensitivity of lung cancer cells through ferroptosis.
Almahi WA, Yu KN, Mohammed F, Kong P, Han W. Almahi WA, et al. Exp Cell Res. 2022 Jan 1;410(1):112946. doi: 10.1016/j.yexcr.2021.112946. Epub 2021 Nov 24. Exp Cell Res. 2022. PMID: 34826424
It was found that the presence of Hemin in irradiated lung cancer cells enhanced the productivity of initial ROS, resulting in lipid peroxidation and subsequent ferroptosis. We observed that application of Hemin as a co-treatment increased the activity of GPx4 degra …
It was found that the presence of Hemin in irradiated lung cancer cells enhanced the productivity of initial ROS, resulting in lipid …
Orientation of Human Microprocessor on Primary MicroRNAs.
Nguyen HM, Nguyen TD, Nguyen TL, Nguyen TA. Nguyen HM, et al. Biochemistry. 2019 Jan 29;58(4):189-198. doi: 10.1021/acs.biochem.8b00944. Epub 2018 Dec 10. Biochemistry. 2019. PMID: 30481000 Review.
Hepcidin Protects Neuron from Hemin-Mediated Injury by Reducing Iron.
Zhou YF, Zhang C, Yang G, Qian ZM, Zhang MW, Ma J, Zhang FL, Ke Y. Zhou YF, et al. Front Physiol. 2017 May 23;8:332. doi: 10.3389/fphys.2017.00332. eCollection 2017. Front Physiol. 2017. PMID: 28588503 Free PMC article.
Hemin plays a key role in mediating secondary neuronal injury after intracerebral hemorrhage (ICH) and the cell toxicity of hemin is thought to be due to iron that is liberated when hemin is degraded. ...Therefore, we hypothesized that hepcidin might be able …
Hemin plays a key role in mediating secondary neuronal injury after intracerebral hemorrhage (ICH) and the cell toxicity of hemin …
Nanozyme Based on Dispersion of Hemin by Graphene Quantum Dots for Colorimetric Detection of Glutathione.
Li Z, Deng X, Hong X, Zhao S. Li Z, et al. Molecules. 2022 Oct 11;27(20):6779. doi: 10.3390/molecules27206779. Molecules. 2022. PMID: 36296372 Free PMC article.
The as-prepared Hemin/GQD nanocomplex had excellent peroxidase-like activity and can be applied as a nanozyme. ...With H(2)O(2) being the substrate, Hemin/GQD nanozyme exhibited a higher maximum reaction rate (V(max)) than HRP. ...
The as-prepared Hemin/GQD nanocomplex had excellent peroxidase-like activity and can be applied as a nanozyme. ...With H(2)O(2) being …
Once-monthly hemin suppresses inflammatory and autoreactive CD4(+) T cell responses to robustly ameliorate experimental rheumatoid arthritis.
Sun B, Li G, Guo L, Yin N, Huang H, Wu X, Huang R, Feng M. Sun B, et al. iScience. 2021 Sep 10;24(10):103101. doi: 10.1016/j.isci.2021.103101. eCollection 2021 Oct 22. iScience. 2021. PMID: 34622156 Free PMC article.
We provided evidence that hemin prevented the onset and ameliorated the clinical course of RA. ...Moreover, we further formulated hemin into the in-situ forming implant, and a single injection of the ultra-long-acting hemin exerted potent disease-modifying ef …
We provided evidence that hemin prevented the onset and ameliorated the clinical course of RA. ...Moreover, we further formulated …
Assembly of Core/Shell Nanospheres of Amorphous Hemin/Acetone-Derived Carbonized Polymer with Graphene Nanosheets for Room-Temperature NO Sensing.
Wang J, Gao Y, Chen F, Zhang L, Li H, de Rooij NF, Umar A, Lee YK, French PJ, Yang B, Wang Y, Zhou G. Wang J, et al. ACS Appl Mater Interfaces. 2022 Nov 30;14(47):53193-53201. doi: 10.1021/acsami.2c16769. Epub 2022 Nov 17. ACS Appl Mater Interfaces. 2022. PMID: 36395355
Implementing parts per billion-level nitric oxide (NO) sensing at room temperature (RT) is still in extreme demand for monitoring inflammatory respiratory diseases. Herein, we have prepared a kind of core-shell structural Hemin-based nanospheres (Abbr.: Hemin-nanosp …
Implementing parts per billion-level nitric oxide (NO) sensing at room temperature (RT) is still in extreme demand for monitoring inflammato …
Microprocessor depends on hemin to recognize the apical loop of primary microRNA.
Nguyen TA, Park J, Dang TL, Choi YG, Kim VN. Nguyen TA, et al. Nucleic Acids Res. 2018 Jun 20;46(11):5726-5736. doi: 10.1093/nar/gky248. Nucleic Acids Res. 2018. PMID: 29750274 Free PMC article.
Furthermore, by generating a DGCR8 mutant cell line and carrying out rescue experiments, we discover that hemin preferentially stimulates the expression of miRNAs possessing the UGU motif, thereby conferring differential regulation of miRNA maturation. Our findings reveal …
Furthermore, by generating a DGCR8 mutant cell line and carrying out rescue experiments, we discover that hemin preferentially stimul …
Roles of JNK/Nrf2 Pathway on Hemin-Induced Heme Oxygenase-1 Activation in MCF-7 Human Breast Cancer Cells.
Jang HY, Hong OY, Chung EY, Park KH, Kim JS. Jang HY, et al. Medicina (Kaunas). 2020 May 29;56(6):268. doi: 10.3390/medicina56060268. Medicina (Kaunas). 2020. PMID: 32485912 Free PMC article.
Hemin enhanced HO-1 expression through the activation of c-Jun N-terminal kinases (JNK) signaling pathway. Hemin also induced activation of Nrf2, a major transcription factor of HO-1 expression. ...
Hemin enhanced HO-1 expression through the activation of c-Jun N-terminal kinases (JNK) signaling pathway. Hemin also induced …
Aptamer-based fluorometric determination of chloramphenicol by controlling the activity of hemin as a peroxidase mimetic.
Wang LC, Hong CY, Lin ZZ, Chen XM, Huang ZY. Wang LC, et al. Anal Methods. 2020 May 14;12(18):2391-2397. doi: 10.1039/d0ay00389a. Anal Methods. 2020. PMID: 32930265
A method for the aptamer-based determination of chloramphenicol (CAP) was developed by exploiting the peroxidase mimicking activity of hemin. The method includes two hemin-modified DNA probes termed P1 and P2. P1, which was modified at its 5' end with one hemin …
A method for the aptamer-based determination of chloramphenicol (CAP) was developed by exploiting the peroxidase mimicking activity of he …
70 results