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Did you mean hein gu (22 results)?
Hemin mitigates contrast-induced nephropathy by inhibiting ferroptosis via HO-1/Nrf2/GPX4 pathway.
Gao Z, Zhang Z, Gu D, Li Y, Zhang K, Dong X, Liu L, Zhang J, Chen J, Wu D, Zeng M. Gao Z, et al. Clin Exp Pharmacol Physiol. 2022 Aug;49(8):858-870. doi: 10.1111/1440-1681.13673. Epub 2022 Jun 10. Clin Exp Pharmacol Physiol. 2022. PMID: 35598290
HK-2 cells insulted by iopromide demonstrated decreased cell vitality and rising reactive oxygen species (ROS), which could also be inhibited by hemin. The effects of hemin involved a key molecule in ferroptosis, glutathione peroxidase (GPX4), whose down-expression …
HK-2 cells insulted by iopromide demonstrated decreased cell vitality and rising reactive oxygen species (ROS), which could also be inhibite …
Hemin as a novel candidate for treating COVID-19 via heme oxygenase-1 induction.
Kim DH, Ahn HS, Go HJ, Kim DY, Kim JH, Lee JB, Park SY, Song CS, Lee SW, Ha SD, Choi C, Choi IS. Kim DH, et al. Sci Rep. 2021 Nov 2;11(1):21462. doi: 10.1038/s41598-021-01054-3. Sci Rep. 2021. PMID: 34728736 Free PMC article.
To confirm whether HO-1 suppresses SARS-CoV-2 infection, we assessed the antiviral activity of hemin, an effective and safe HO-1 inducer, in SARS-CoV-2 infection. We found that treatment with hemin efficiently suppressed SARS-CoV-2 replication (selectivity index: 24 …
To confirm whether HO-1 suppresses SARS-CoV-2 infection, we assessed the antiviral activity of hemin, an effective and safe HO-1 indu …
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis-associated infertility patients.
Dai Y, Lin X, Liu N, Shi L, Zhuo F, Huang Q, Gu W, Zhao F, Zhang Y, Zhang Y, Pan Y, Zhang S. Dai Y, et al. J Pathol. 2023 Jul;260(3):248-260. doi: 10.1002/path.6079. Epub 2023 Mar 29. J Pathol. 2023. PMID: 36992523
Upregulated PI and downregulated LPI correlated with oocyte retrieval number and mature oocyte number. LPI inhibited cellular reactive oxidative stress induced by hemin in granulosa cells. Cell proliferation inhibition, senescence, and apoptosis induced by hemin wer …
Upregulated PI and downregulated LPI correlated with oocyte retrieval number and mature oocyte number. LPI inhibited cellular reactive oxida …
Exogenous Hemin alleviated cadmium stress in maize (Zea mays L.) by enhancing leaf photosynthesis, AsA-GSH cycle and polyamine metabolism.
Piao L, Wang Y, Liu X, Sun G, Zhang S, Yan J, Chen Y, Meng Y, Li M, Gu W. Piao L, et al. Front Plant Sci. 2022 Sep 8;13:993675. doi: 10.3389/fpls.2022.993675. eCollection 2022. Front Plant Sci. 2022. PMID: 36160952 Free PMC article.
Cadmium (Cd) stress is one of the principal abiotic stresses that inhibit maize growth. The research was to explore (hemin chloride) Hemin (100 mumol L(-1)) on photosynthesis, ascorbic acid (AsA)-glutathione (GSH) cycle system, and polyamine metabolism of maize unde …
Cadmium (Cd) stress is one of the principal abiotic stresses that inhibit maize growth. The research was to explore (hemin chloride) …
Exogenous Hemin alleviates cadmium stress in maize by enhancing sucrose and nitrogen metabolism and regulating endogenous hormones.
Zhao M, Meng Y, Wang Y, Sun G, Liu X, Li J, Wei S, Gu W. Zhao M, et al. Int J Phytoremediation. 2023;25(3):368-380. doi: 10.1080/15226514.2022.2086212. Epub 2022 Jun 22. Int J Phytoremediation. 2023. PMID: 35732582
Cadmium (Cd) stress restricts maize growth and productivity severely. We aimed to investigate the effects of Hemin on the metabolism of sucrose and nitrogen and endogenous hormones in maize under cadmium stress. ...This work further investigates the effects of Hemin …
Cadmium (Cd) stress restricts maize growth and productivity severely. We aimed to investigate the effects of Hemin on the metabolism …
Noncovalent minimal assembly of exogenous histamine with hemin cofactor as a peroxidase-mimicking cooperative catalyst.
Kang B, Park G, Kim SH, Lee D, Oh SS. Kang B, et al. iScience. 2022 Oct 2;25(10):105257. doi: 10.1016/j.isci.2022.105257. eCollection 2022 Oct 21. iScience. 2022. PMID: 36274946 Free PMC article.
Although the molecular weight of hemin-histamine pair is 763, 1.7% of the horseradish peroxidase, cooperative catalysis of two natural molecules exhibits 17.3 times greater catalytic efficiency (17.93 M(-1)s(-1)) and 57.8 times larger specific activity (36.45 mumol/min.mg) …
Although the molecular weight of hemin-histamine pair is 763, 1.7% of the horseradish peroxidase, cooperative catalysis of two natura …
Selective Hemin Binding by a Non-G-quadruplex Aptamer with Higher Affinity and Better Peroxidase-like Activity.
Gu L, Ding Y, Zhou Y, Zhang Y, Wang D, Liu J. Gu L, et al. Angew Chem Int Ed Engl. 2024 Feb 5;63(6):e202314450. doi: 10.1002/anie.202314450. Epub 2024 Jan 10. Angew Chem Int Ed Engl. 2024. PMID: 38150561
In this work, we used the capture selection method to obtain aptamers for hemin and protoporphyrin IX (PPIX). The hemin aptamer (Hem1) features two highly conserved repeating binding loops, and it cannot form a G-quadruplex, which was supported by its Mg(2+) -depend …
In this work, we used the capture selection method to obtain aptamers for hemin and protoporphyrin IX (PPIX). The hemin aptame …
A tumor cell membrane-coated self-amplified nanosystem as a nanovaccine to boost the therapeutic effect of anti-PD-L1 antibody.
Li Z, Cai H, Li Z, Ren L, Ma X, Zhu H, Gong Q, Zhang H, Gu Z, Luo K. Li Z, et al. Bioact Mater. 2022 Sep 13;21:299-312. doi: 10.1016/j.bioactmat.2022.08.028. eCollection 2023 Mar. Bioact Mater. 2022. PMID: 36157245 Free PMC article.
Herein, a self-amplified biomimetic nanosystem, mEHGZ, was constructed by encapsulation of epirubicin (EPI), glucose oxidase (Gox) and hemin in ZIF-8 nanoparticles and coating of the nanoparticles with calreticulin (CRT) over-expressed tumor cell membrane. EPI acts as an I …
Herein, a self-amplified biomimetic nanosystem, mEHGZ, was constructed by encapsulation of epirubicin (EPI), glucose oxidase (Gox) and he …
Attenuation of neuronal ferroptosis in intracerebral hemorrhage by inhibiting HDAC1/2: Microglial heterogenization via the Nrf2/HO1 pathway.
Jiang Z, Yang H, Ni W, Gao X, Pei X, Jiang H, Su J, Weng R, Fei Y, Gao Y, Gu Y. Jiang Z, et al. CNS Neurosci Ther. 2024 Mar;30(3):e14646. doi: 10.1111/cns.14646. CNS Neurosci Ther. 2024. PMID: 38523117 Free PMC article.
METHODS: In both in vivo and in vitro models of ICH, we used Romidepsin (FK228), a selective HDAC1/2 inhibitor, to investigate its effects on microglial heterogenization and neuronal ferroptosis. In the in vitro ICH model using Hemin, a transwell system was utilized to exa …
METHODS: In both in vivo and in vitro models of ICH, we used Romidepsin (FK228), a selective HDAC1/2 inhibitor, to investigate its effects o …
Light amplified oxidative stress in tumor microenvironment by carbonized hemin nanoparticles for boosting photodynamic anticancer therapy.
Lin L, Pang W, Jiang X, Ding S, Wei X, Gu B. Lin L, et al. Light Sci Appl. 2022 Mar 1;11(1):47. doi: 10.1038/s41377-021-00704-5. Light Sci Appl. 2022. PMID: 35228527 Free PMC article.
Herein, we reported a newly engineered PS of polymer encapsulated carbonized hemin nanoparticles (P-CHNPs) via a facile synthesis procedure for boosting photodynamic anticancer therapy. Solvothermal treatment of hemin enabled the synthesized P-CHNPs to enhance oxida …
Herein, we reported a newly engineered PS of polymer encapsulated carbonized hemin nanoparticles (P-CHNPs) via a facile synthesis pro …
66 results