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A laccase-catalysed tyrosine click reaction.
Sato S, Nakane K, Nakamura H. Sato S, et al. Org Biomol Chem. 2020 May 20;18(19):3664-3668. doi: 10.1039/d0ob00650e. Org Biomol Chem. 2020. PMID: 32356542
Laccase-catalysed tyrosine-specific modification under mild reaction conditions (shaking at 37 C) was more efficient than previously reported tyrosine click reactions using hemin, horseradish peroxidase (HRP) or electrochemistry....
Laccase-catalysed tyrosine-specific modification under mild reaction conditions (shaking at 37 C) was more efficient than previously reporte …
Hemin treatment abrogates monocrotaline-induced pulmonary hypertension.
Shimzu K, Takahashi T, Iwasaki T, Shimizu H, Inoue K, Morimatsu H, Omori E, Matsumi M, Akagi R, Morita K. Shimzu K, et al. Med Chem. 2008 Nov;4(6):572-6. doi: 10.2174/157340608786241972. Med Chem. 2008. PMID: 18991742 Free article.
MCT administration caused pulmonary arterial wall thickening with marked elevation of right ventricular pressure, in association with prominent pulmonary inflammation as revealed by the increase in gene expression of tumor necrosis factor-alpha and the number of infiltrated neutr …
MCT administration caused pulmonary arterial wall thickening with marked elevation of right ventricular pressure, in association with promin …
Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors.
Kim YC, Masutani H, Yamaguchi Y, Itoh K, Yamamoto M, Yodoi J. Kim YC, et al. J Biol Chem. 2001 May 25;276(21):18399-406. doi: 10.1074/jbc.M100103200. Epub 2001 Mar 1. J Biol Chem. 2001. PMID: 11279008 Free article.
The binding of the Nrf2/small Maf complex to ARE was induced by hemin, whereas the binding of Jun/Fos proteins to ARE was induced by phorbol 12-myristate 13-acetate, but not hemin. ...Overexpression of Nrf2 augmented the response to hemin in a dose-dependent …
The binding of the Nrf2/small Maf complex to ARE was induced by hemin, whereas the binding of Jun/Fos proteins to ARE was induced by …
Quantitative analysis of hemin-induced neutrophil extracellular trap formation and effects of hydrogen peroxide on this phenomenon.
Ohbuchi A, Kono M, Kitagawa K, Takenokuchi M, Imoto S, Saigo K. Ohbuchi A, et al. Biochem Biophys Rep. 2017 Jul 24;11:147-153. doi: 10.1016/j.bbrep.2017.07.009. eCollection 2017 Sep. Biochem Biophys Rep. 2017. PMID: 28955779 Free PMC article.
In the presence of low concentrations of hydrogen peroxide, low concentrations of hemin-induced NETs were enhanced, unlike those of phorbol myristate acetate (PMA)-induced NETs. Quantitative analysis of NET formation may prove to be a useful tool for investigating NET phys …
In the presence of low concentrations of hydrogen peroxide, low concentrations of hemin-induced NETs were enhanced, unlike those of p …
Hemin inhibits cyclin D1 and IGF-1 expression via STAT5b under hypoxia in ERalpha-negative MDA-MB 231 breast cancer cells.
Lim EJ, Joung YH, Jung SM, Park SH, Park JH, Kim SY, Hwang TS, Hong DY, Chung SC, Ye SK, Moon ES, Park EU, Park T, Chung IM, Yang YM. Lim EJ, et al. Int J Oncol. 2010 May;36(5):1243-51. doi: 10.3892/ijo_00000608. Int J Oncol. 2010. PMID: 20372799
EMSA studies showed that STAT5 binding activity to the IGF-1 and cyclin D1 promoter was distinctly decreased by hemin in STAT5b-transfected COS-7 or MDA-MB 231 cells. IGF-1 gene expression was also decreased by hemin in mammary epithelial cells. ...These data indica …
EMSA studies showed that STAT5 binding activity to the IGF-1 and cyclin D1 promoter was distinctly decreased by hemin in STAT5b-trans …
Enhancement of DNAzymatic activity using iterative in silico maturation.
Fenati RA, Chen Z, Yamagishi Y, Tsukakoshi K, Ikebukuor K, Manian A, Russo SP, Yamazaki T, Ellis AV. Fenati RA, et al. J Mater Chem B. 2022 Nov 9;10(43):8960-8969. doi: 10.1039/d2tb01638a. J Mater Chem B. 2022. PMID: 36285587
In this work, iterative in silico maturation and in vitro evaluation were applied to a DNAzyme oligodeoxynucleotide (ODN) sequence to elucidate novel synthetic sequences with enhanced DNAzyme activity. An already well-known model DNAzyme, the G-quadruplex/hemin complex, wa …
In this work, iterative in silico maturation and in vitro evaluation were applied to a DNAzyme oligodeoxynucleotide (ODN) sequence to elucid …
Specific binding of anionic porphyrin and phthalocyanine to the G-quadruplex with a variety of in vitro and in vivo applications.
Yaku H, Murashima T, Miyoshi D, Sugimoto N. Yaku H, et al. Molecules. 2012 Sep 5;17(9):10586-613. doi: 10.3390/molecules170910586. Molecules. 2012. PMID: 22951397 Free PMC article. Review.
The G-quadruplex and hemin-G-quadruplex complex allow development of sensing techniques to detect DNA, metal ions and proteins. In addition to hemin, anionic phthalocyanines also bind to the G-quadruplex formed by human telomere DNA, specifically over ssDNA and dsDN …
The G-quadruplex and hemin-G-quadruplex complex allow development of sensing techniques to detect DNA, metal ions and proteins. In ad …
Activated microglia are less vulnerable to hemin toxicity due to nitric oxide-dependent inhibition of JNK and p38 MAPK activation.
Cai Y, Cho GS, Ju C, Wang SL, Ryu JH, Shin CY, Kim HS, Nam KW, Jalin AM, Sun W, Choi IY, Kim WK. Cai Y, et al. J Immunol. 2011 Aug 1;187(3):1314-21. doi: 10.4049/jimmunol.1002925. Epub 2011 Jun 27. J Immunol. 2011. PMID: 21709153
Similarly, intracorpus callosum microinjection of LPS prior to hemin treatment reduced the brain tissue damage caused by hemin and increased microglial density in the penumbra in rats. ...The preventive effect by LPS was significantly diminished by an iNOS inhibitor …
Similarly, intracorpus callosum microinjection of LPS prior to hemin treatment reduced the brain tissue damage caused by hemin …
Role of the hemin-binding protein 35 (HBP35) of Porphyromonas gingivalis in coaggregation.
Hiratsuka K, Hayakawa M, Kiyama-Kishikawa M, Sasaki Y, Hirai T, Abiko Y. Hiratsuka K, et al. Microb Pathog. 2008 Apr;44(4):320-8. doi: 10.1016/j.micpath.2007.10.006. Epub 2007 Oct 24. Microb Pathog. 2008. PMID: 18053679
Hemin-binding protein 35 (HBP35) in Porphyromonas gingivalis is one of the outer membrane proteins and has been reported to be a non-fimbrial coaggregation factor. ...
Hemin-binding protein 35 (HBP35) in Porphyromonas gingivalis is one of the outer membrane proteins and has been reported to be a non- …
Hemin (Fe(3+))-- and heme (Fe(2+))--smectite conjugates as a model of hemoprotein based on spectrophotometry.
Itoh T, Yamada T, Kodera Y, Matsushima A, Hiroto M, Sakurai K, Nishimura H, Inada Y. Itoh T, et al. Bioconjug Chem. 2001 Jan-Feb;12(1):3-6. doi: 10.1021/bc000055q. Bioconjug Chem. 2001. PMID: 11170361
Hemin (Fe(3+)) was adsorbed onto synthetic smectite (clay mineral) in acetone to form a hemin-smectite conjugate. The hemin-smectite conjugate became soluble in water to form a transparent colloidal solution with a dark brown color. ...
Hemin (Fe(3+)) was adsorbed onto synthetic smectite (clay mineral) in acetone to form a hemin-smectite conjugate. The hemin …
61 results