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Modular cytokine receptor-targeting chimeras for targeted degradation of cell surface and extracellular proteins.
Pance K, Gramespacher JA, Byrnes JR, Salangsang F, Serrano JC, Cotton AD, Steri V, Wells JA. Pance K, et al. Nat Biotechnol. 2023 Feb;41(2):273-281. doi: 10.1038/s41587-022-01456-2. Epub 2022 Sep 22. Nat Biotechnol. 2023. PMID: 36138170 Free PMC article.
We show that KineTACs containing the cytokine CXCL12 can use the decoy recycling receptor, CXCR7, to target a variety of target proteins to the lysosome for degradation. ...
We show that KineTACs containing the cytokine CXCL12 can use the decoy recycling receptor, CXCR7, to target a variety of target prote …
Semaphorin-PlexinD1 signaling limits angiogenic potential via the VEGF decoy receptor sFlt1.
Zygmunt T, Gay CM, Blondelle J, Singh MK, Flaherty KM, Means PC, Herwig L, Krudewig A, Belting HG, Affolter M, Epstein JA, Torres-Vázquez J. Zygmunt T, et al. Dev Cell. 2011 Aug 16;21(2):301-14. doi: 10.1016/j.devcel.2011.06.033. Epub 2011 Jul 28. Dev Cell. 2011. PMID: 21802375 Free PMC article.
Specifically, Sema-PlxnD1 signaling ensures the proper endothelial abundance of soluble flt1 (sflt1), an alternatively spliced form of the VEGF receptor Flt1 encoding a potent secreted decoy. Hence, Sema-PlxnD1 signaling regulates distinct but related aspects of angiogenes …
Specifically, Sema-PlxnD1 signaling ensures the proper endothelial abundance of soluble flt1 (sflt1), an alternatively spliced form of the V …
Cytomegalovirus evasion of natural killer cell responses.
Farrell HE, Degli-Esposti MA, Davis-Poynter NJ. Farrell HE, et al. Immunol Rev. 1999 Apr;168:187-97. doi: 10.1111/j.1600-065x.1999.tb01293.x. Immunol Rev. 1999. PMID: 10399075 Review.
The class I MHC homologues, encoded by all cytomegaloviruses characterised to date, have been implicated as molecular 'decoys', which may mimic the ability of cellular MHC class I to inhibit NK-cell functions. ...
The class I MHC homologues, encoded by all cytomegaloviruses characterised to date, have been implicated as molecular 'decoys', which …
Soluble receptor for advanced glycation end products: a new biomarker in diagnosis and prognosis of chronic inflammatory diseases.
Maillard-Lefebvre H, Boulanger E, Daroux M, Gaxatte C, Hudson BI, Lambert M. Maillard-Lefebvre H, et al. Rheumatology (Oxford). 2009 Oct;48(10):1190-6. doi: 10.1093/rheumatology/kep199. Epub 2009 Jul 9. Rheumatology (Oxford). 2009. PMID: 19589888 Review.
AGEs, through interacting with their specific receptor for AGEs (RAGE), result in activation of pro-inflammatory states and are involved in numerous pathologic situations. The soluble form of RAGE (sRAGE) is able to act as a decoy to avoid interaction of RAGE with its pro- …
AGEs, through interacting with their specific receptor for AGEs (RAGE), result in activation of pro-inflammatory states and are involved in …
Surflex-Dock: Docking benchmarks and real-world application.
Spitzer R, Jain AN. Spitzer R, et al. J Comput Aided Mol Des. 2012 Jun;26(6):687-99. doi: 10.1007/s10822-011-9533-y. Epub 2012 May 9. J Comput Aided Mol Des. 2012. PMID: 22569590 Free PMC article.
Benchmarks for molecular docking have historically focused on re-docking the cognate ligand of a well-determined protein-ligand complex to measure geometric pose prediction accuracy, and measurement of virtual screening performance has been focused on increasingly large and diver …
Benchmarks for molecular docking have historically focused on re-docking the cognate ligand of a well-determined protein-ligand complex to m …
Hepatitis B surface antigen on subviral particles reduces the neutralizing effect of anti-HBs antibodies on hepatitis B viral particles in vitro.
Rydell GE, Prakash K, Norder H, Lindh M. Rydell GE, et al. Virology. 2017 Sep;509:67-70. doi: 10.1016/j.virol.2017.05.017. Epub 2017 Jun 10. Virology. 2017. PMID: 28605637 Free article.
Our findings showed that SVP significantly reduced the neutralization of VP by anti-HBs, while SVP had little effect on viral entry, supporting the assumption that SVP serve as decoy facilitating cell-to-cell spread of HBV in the presence of neutralizing antibodies....
Our findings showed that SVP significantly reduced the neutralization of VP by anti-HBs, while SVP had little effect on viral entry, support …