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Page 1
Showing results for hao zheng n
Search for hao zhengan instead (3 results)
N protein of PEDV plays chess game with host proteins by selective autophagy.
Zhai X, Kong N, Zhang Y, Song Y, Qin W, Yang X, Ye C, Ye M, Tong W, Liu C, Zheng H, Yu H, Zhang W, Yang X, Zhang G, Tong G, Shan T. Zhai X, et al. Among authors: zheng h. Autophagy. 2023 Aug;19(8):2338-2352. doi: 10.1080/15548627.2023.2181615. Epub 2023 Mar 2. Autophagy. 2023. PMID: 36861818 Free PMC article.
In this study, we have found a novel host restriction factor, HNRNPA1, that could inhibit PEDV replication by degrading viral nucleocapsid (N) protein. The restriction factor activates the HNRNPA1-MARCHF8/MARCH8-CALCOCO2/NDP52-autophagosome pathway with the help of transcr …
In this study, we have found a novel host restriction factor, HNRNPA1, that could inhibit PEDV replication by degrading viral nucleocapsid ( …
Scutellarin Rescued Mitochondrial Damage through Ameliorating Mitochondrial Glucose Oxidation via the Pdk-Pdc Axis.
Sheng N, Zhang Z, Zheng H, Ma C, Li M, Wang Z, Wang L, Jiang J, Zhang J. Sheng N, et al. Among authors: zheng h. Adv Sci (Weinh). 2023 Nov;10(32):e2303584. doi: 10.1002/advs.202303584. Epub 2023 Sep 26. Adv Sci (Weinh). 2023. PMID: 37750289 Free PMC article.
Mitochondrial proteomics, energy metabolism monitoring, and (13) C-metabolic flux analysis targeted SG activity on PDK2, thus regulating PDK-PDC-mediated glycolytic metabolism to TCA cycle during mitochondrial OXPHOS damage. The knockdown of PDK2 in the SK-N-SH cells valid …
Mitochondrial proteomics, energy metabolism monitoring, and (13) C-metabolic flux analysis targeted SG activity on PDK2, thus regulating PDK …
BST2 suppresses porcine epidemic diarrhea virus replication by targeting and degrading virus nucleocapsid protein with selective autophagy.
Kong N, Shan T, Wang H, Jiao Y, Zuo Y, Li L, Tong W, Yu L, Jiang Y, Zhou Y, Li G, Gao F, Yu H, Zheng H, Tong G. Kong N, et al. Among authors: zheng h. Autophagy. 2020 Oct;16(10):1737-1752. doi: 10.1080/15548627.2019.1707487. Epub 2019 Dec 27. Autophagy. 2020. PMID: 31868081 Free PMC article.
We also showed that BST2 suppressed PEDV replication by binding and degrading the PEDV-encoded nucleocapsid (N) protein. The downregulation of N protein was blocked by macroautophagy/autophagy inhibitors but not a proteasome inhibitor, implying that the N pro …
We also showed that BST2 suppressed PEDV replication by binding and degrading the PEDV-encoded nucleocapsid (N) protein. The downregu …
TARDBP Inhibits Porcine Epidemic Diarrhea Virus Replication through Degrading Viral Nucleocapsid Protein and Activating Type I Interferon Signaling.
Dong S, Kong N, Zhang Y, Li Y, Sun D, Qin W, Zhai H, Zhai X, Yang X, Ye C, Ye M, Liu C, Yu L, Zheng H, Tong W, Yu H, Zhang W, Tong G, Shan T. Dong S, et al. Among authors: zheng h. J Virol. 2022 May 25;96(10):e0007022. doi: 10.1128/jvi.00070-22. Epub 2022 May 2. J Virol. 2022. PMID: 35499322 Free PMC article.
We observed that through the proteasomal and autophagic degradation pathway, TARDBP inhibited PEDV replication via the binding as well as degradation of PEDV-encoded nucleocapsid (N) protein. Moreover, we found that TARDBP promoted autophagic degradation of N protei …
We observed that through the proteasomal and autophagic degradation pathway, TARDBP inhibited PEDV replication via the binding as well as de …
N(6)-Methyladenosine Modification of ANLN Enhances Hepatocellular Carcinoma Bone Metastasis.
Zheng H, Cheng ZJ, Liang B, Wang ZG, Tao YP, Huang SY, Ni JS, Li HF, Yang L, Yuan SX, Wu J, Kawaguchi T, Samant H, Zhou WP, Xiang DM, Yang Y. Zheng H, et al. Int J Biol Sci. 2023 Jan 22;19(4):1009-1023. doi: 10.7150/ijbs.73570. eCollection 2023. Int J Biol Sci. 2023. PMID: 36923927 Free PMC article.
Bones are categorized as the second most prevalent location of extra-hepatic metastasis in Hepatocellular Carcinoma (HCC), which is linked to an extremely poor prognosis due to limited therapeutic options. N(6)-methyladenosine (m(6)A) is a prominent modification involved i …
Bones are categorized as the second most prevalent location of extra-hepatic metastasis in Hepatocellular Carcinoma (HCC), which is linked t …
PTBP1 suppresses porcine epidemic diarrhea virus replication via inducing protein degradation and IFN production.
Qin W, Kong N, Zhang Y, Wang C, Dong S, Zhai H, Zhai X, Yang X, Ye C, Ye M, Tong W, Liu C, Yu L, Zheng H, Yu H, Zhang W, Lan D, Tong G, Shan T. Qin W, et al. Among authors: zheng h. J Biol Chem. 2023 Aug;299(8):104987. doi: 10.1016/j.jbc.2023.104987. Epub 2023 Jun 29. J Biol Chem. 2023. PMID: 37392846 Free PMC article.
PTBP1 was upregulated during PEDV infection. The PEDV nucleocapsid (N) protein was degraded through the autophagic and proteasomal degradation pathways. Moreover, PTBP1 recruits MARCH8 (an E3 ubiquitin ligase) and NDP52 (a cargo receptor) for N protein catalysis and …
PTBP1 was upregulated during PEDV infection. The PEDV nucleocapsid (N) protein was degraded through the autophagic and proteasomal de …
PGAM5 degrades PDCoV N protein and activates type I interferon to antagonize viral replication.
Yang X, Kong N, Qin W, Zhai X, Song Y, Tong W, Li L, Liu C, Zheng H, Yu H, Zhang W, Tong G, Shan T. Yang X, et al. Among authors: zheng h. J Virol. 2023 Nov 30;97(11):e0147023. doi: 10.1128/jvi.01470-23. Epub 2023 Oct 26. J Virol. 2023. PMID: 37882521 Free PMC article.
Our research has revealed that PDCoV infection down-regulates the expression of PGAM5 to promote virus replication. In contrast, PGAM5 degrades PDCoV N through autophagy by interacting with the cargo receptor P62 and the E3 ubiquitination ligase STUB1. ...
Our research has revealed that PDCoV infection down-regulates the expression of PGAM5 to promote virus replication. In contrast, PGAM5 degra …
Ferroptosis contributes to multiple sclerosis and its pharmacological targeting suppresses experimental disease progression.
Van San E, Debruyne AC, Veeckmans G, Tyurina YY, Tyurin VA, Zheng H, Choi SM, Augustyns K, van Loo G, Michalke B, Venkataramani V, Toyokuni S, Bayir H, Vandenabeele P, Hassannia B, Vanden Berghe T. Van San E, et al. Among authors: zheng h. Cell Death Differ. 2023 Sep;30(9):2092-2103. doi: 10.1038/s41418-023-01195-0. Epub 2023 Aug 4. Cell Death Differ. 2023. PMID: 37542104 Free PMC article.
A non-canonical retina-ipRGCs-SCN-PVT visual pathway for mediating contagious itch behavior.
Gao F, Ma J, Yu YQ, Gao XF, Bai Y, Sun Y, Liu J, Liu X, Barry DM, Wilhelm S, Piccinni-Ash T, Wang N, Liu D, Ross RA, Hao Y, Huang X, Jia JJ, Yang Q, Zheng H, van Nispen J, Chen J, Li H, Zhang J, Li YQ, Chen ZF. Gao F, et al. Among authors: zheng h. Cell Rep. 2022 Oct 4;41(1):111444. doi: 10.1016/j.celrep.2022.111444. Cell Rep. 2022. PMID: 36198265 Free PMC article.
PEDV N protein capture protein translation element PABPC1 and eIF4F to promote viral replication.
Zhai H, Qin W, Dong S, Yang X, Zhai X, Tong W, Liu C, Zheng H, Yu H, Kong N, Tong G, Shan T. Zhai H, et al. Among authors: zheng h. Vet Microbiol. 2023 Sep;284:109844. doi: 10.1016/j.vetmic.2023.109844. Epub 2023 Aug 9. Vet Microbiol. 2023. PMID: 37572396
In this study, we found that there is an interaction between PEDV N, polyadenylate-binding protein cytoplasmic 1 (PABPC1) and eukaryotic initiation factor 4F (eIF4F) proteins through coimmunoprecipitation, GST pulldown and fluorescence microscopy experiments. ...Taken toge …
In this study, we found that there is an interaction between PEDV N, polyadenylate-binding protein cytoplasmic 1 (PABPC1) and eukaryo …
142 results