Quantification of drug metabolising enzymes and transporter proteins in the paediatric duodenum via LC-MS/MS proteomics using a QconCAT technique.
Goelen J, Farrell G, McGeehan J, Titman CM, J W Rattray N, Johnson TN, Horniblow RD, Batchelor HK.
Goelen J, et al.
Eur J Pharm Biopharm. 2023 Oct;191:68-77. doi: 10.1016/j.ejpb.2023.08.011. Epub 2023 Aug 23.
Eur J Pharm Biopharm. 2023.
PMID: 37625656
Free article.
In particular, the ontogeny of key intestinal Drug Metabolising Enzymes and Transporter (DMET) proteins involved in drug disposition needs to be elucidated to allow for accurate prediction of the PK profile of drugs in the paediatric cohort. Using pinch biopsies from the p …
In particular, the ontogeny of key intestinal Drug Metabolising Enzymes and Transporter (DMET) proteins involved in drug disposition needs t …