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Page 1
Did you mean han chao qun (11 results)?
4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects.
Liao ST, Han C, Xu DQ, Fu XW, Wang JS, Kong LY. Liao ST, et al. Among authors: han c. Nat Commun. 2019 Nov 8;10(1):5091. doi: 10.1038/s41467-019-13078-5. Nat Commun. 2019. PMID: 31704924 Free PMC article.
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential therapeutic target in inflammatory disease. The endogenous metabolite itaconate has been reported to regulate macrophage function, but i …
Activated macrophages switch from oxidative phosphorylation to aerobic glycolysis, similar to the Warburg effect, presenting a potential …
The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.
Kou L, Chi X, Sun Y, Han C, Wan F, Hu J, Yin S, Wu J, Li Y, Zhou Q, Zou W, Xiong N, Huang J, Xia Y, Wang T. Kou L, et al. Among authors: han c. J Neuroinflammation. 2022 Jun 6;19(1):133. doi: 10.1186/s12974-022-02494-y. J Neuroinflammation. 2022. PMID: 35668454 Free PMC article.
CONCLUSIONS: These observations suggest that the circadian clock protein Rev-erbalpha plays an essential role in attenuating neuroinflammation in PD pathology, and provides a potential therapeutic target for PD treatment....
CONCLUSIONS: These observations suggest that the circadian clock protein Rev-erbalpha plays an essential role in attenuating neuroinflammati …
Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation.
Chen C, Zhang W, Zhou T, Liu Q, Han C, Huang Z, Chen S, Mei Q, Zhang C, Zhang K, Ma H, Zhou R, Jiang W, Pan W, Zhu S. Chen C, et al. Among authors: han c. Cell Rep. 2022 Nov 29;41(9):111741. doi: 10.1016/j.celrep.2022.111741. Cell Rep. 2022. PMID: 36450257 Free article.
However, the environmental metabolic checkpoints with specific regulation of Th17 cells, manifesting potential therapeutic opportunities to autoimmune diseases, remain largely unknown. ...Collectively, our study demonstrates a role of VB5 in Th17 cell metabolic reprogramin …
However, the environmental metabolic checkpoints with specific regulation of Th17 cells, manifesting potential therapeutic opportunit …
Structural mechanism for specific binding of chemical compounds to amyloid fibrils.
Tao Y, Xia W, Zhao Q, Xiang H, Han C, Zhang S, Gu W, Tang W, Li Y, Tan L, Li D, Liu C. Tao Y, et al. Among authors: han c. Nat Chem Biol. 2023 Oct;19(10):1235-1245. doi: 10.1038/s41589-023-01370-x. Epub 2023 Jul 3. Nat Chem Biol. 2023. PMID: 37400537
Amyloid fibril is an important pharmaceutical target for diagnostic and therapeutic treatment of neurodegenerative diseases. However, rational design of chemical compounds that interact with amyloid fibrils is unachievable due to the lack of mechanistic understanding of th …
Amyloid fibril is an important pharmaceutical target for diagnostic and therapeutic treatment of neurodegenerative diseases. However, …
Proteomics, Personalized Medicine and Cancer.
Su M, Zhang Z, Zhou L, Han C, Huang C, Nice EC. Su M, et al. Among authors: han c. Cancers (Basel). 2021 May 21;13(11):2512. doi: 10.3390/cancers13112512. Cancers (Basel). 2021. PMID: 34063807 Free PMC article. Review.
This has been largely achieved by major technological advances over the last 20 years and has enlarged our understanding of human health and disease, including cancer, and is supporting the current trend towards personalized/precision medicine. This is due to improved screening, …
This has been largely achieved by major technological advances over the last 20 years and has enlarged our understanding of human health and …
Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease.
Li Y, Lu Y, Nian M, Sheng Q, Zhang C, Han C, Dou X, Ding Y. Li Y, et al. Among authors: han c. Chin J Nat Med. 2023 Sep;21(9):643-657. doi: 10.1016/S1875-5364(23)60443-1. Chin J Nat Med. 2023. PMID: 37777315 Review.
In this review, the role of CHMs in the treatment of liver fibrosis is described, based on studies over the past decade, which has addressed the various mechanisms and signaling pathways that mediate therapeutic efficacy. Among them, inhibition of stellate cell activation …
In this review, the role of CHMs in the treatment of liver fibrosis is described, based on studies over the past decade, which has addressed …
Carrier-free nanoplatforms from natural plants for enhanced bioactivity.
Li Z, Xu X, Wang Y, Kong L, Han C. Li Z, et al. Among authors: han c. J Adv Res. 2023 Aug;50:159-176. doi: 10.1016/j.jare.2022.09.013. Epub 2022 Oct 5. J Adv Res. 2023. PMID: 36208834 Free PMC article. Review.
Carrier-free nanoplatforms completely self-assembled by pure molecules or therapeutic components have attracted increasing attention due to their advantages of improved pharmacodynamics/pharmacokinetics, reduced toxicity, and high drug loading. In recent years, carrier-fre …
Carrier-free nanoplatforms completely self-assembled by pure molecules or therapeutic components have attracted increasing attention …
Disulfiram relieves severe acute pancreatitis by inhibiting GSDMD-dependent NETs formation.
Ling X, Nie C, Sheng LP, Han CQ, Ding Z. Ling X, et al. Among authors: han cq. J Dig Dis. 2023 May;24(5):359-368. doi: 10.1111/1751-2980.13211. J Dig Dis. 2023. PMID: 37503822
DSL inhibits NETs formation by downregulating GSDMD, which in turn relieves the inflammation of SAP. Our study may provide a possible therapeutic target for SAP....
DSL inhibits NETs formation by downregulating GSDMD, which in turn relieves the inflammation of SAP. Our study may provide a possible the …
Potassium channels and their role in glioma: A mini review.
Liu J, Qu C, Han C, Chen MM, An LJ, Zou W. Liu J, et al. Among authors: han c. Mol Membr Biol. 2019 Dec;35(1):76-85. doi: 10.1080/09687688.2020.1729428. Mol Membr Biol. 2019. PMID: 32067536 Review.
Because the blood-brain barrier and other factors lead to a lower effective concentration of chemotherapeutic drugs in the tumor, the recurrence rate of residual lesions is extremely high. Therefore, new therapeutic methods are needed. Numerous studies have shown that diff …
Because the blood-brain barrier and other factors lead to a lower effective concentration of chemotherapeutic drugs in the tumor, the recurr …
154 results