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Down-regulation of CatSper1 channel in epididymal spermatozoa contributes to the pathogenesis of asthenozoospermia, whereas up-regulation of the channel by Sheng-Jing-San treatment improves the sperm motility of asthenozoospermia in rats.
Wang YN, Wang B, Liang M, Han CY, Zhang B, Cai J, Sun W, Xing GG. Wang YN, et al. Among authors: han cy. Fertil Steril. 2013 Feb;99(2):579-87. doi: 10.1016/j.fertnstert.2012.10.030. Epub 2012 Nov 10. Fertil Steril. 2013. PMID: 23148924 Clinical Trial.