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Year Number of Results
1909 2
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1946 2
1947 1
1948 1
1949 2
1950 2
1951 4
1952 3
1953 6
1954 7
1955 2
1956 10
1957 8
1958 5
1959 8
1960 7
1961 9
1962 10
1963 9
1964 17
1965 14
1966 15
1967 12
1968 23
1969 21
1970 34
1971 36
1972 32
1973 52
1974 43
1975 87
1976 116
1977 116
1978 152
1979 176
1980 203
1981 171
1982 202
1983 255
1984 246
1985 270
1986 267
1987 300
1988 294
1989 303
1990 397
1991 455
1992 425
1993 519
1994 515
1995 507
1996 533
1997 619
1998 575
1999 637
2000 629
2001 660
2002 673
2003 730
2004 756
2005 808
2006 856
2007 925
2008 903
2009 910
2010 947
2011 1099
2012 1155
2013 1256
2014 1211
2015 1231
2016 1248
2017 1233
2018 1178
2019 1266
2020 1366
2021 1433
2022 1429
2023 1279
2024 536

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31,826 results

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Page 1
Mechanisms of Hair Cell Damage and Repair.
Wagner EL, Shin JB. Wagner EL, et al. Trends Neurosci. 2019 Jun;42(6):414-424. doi: 10.1016/j.tins.2019.03.006. Epub 2019 Apr 13. Trends Neurosci. 2019. PMID: 30992136 Free PMC article. Review.
This damage can manifest in many forms, from dysfunction of the hair cell mechanotransduction complex to loss of specialized ribbon synapses, and may even result in hair cell death. Given that mammalian hair cells do not regenerate, the r …
This damage can manifest in many forms, from dysfunction of the hair cell mechanotransduction complex to loss of specialized r …
Hair cell regeneration.
Edge AS, Chen ZY. Edge AS, et al. Curr Opin Neurobiol. 2008 Aug;18(4):377-82. doi: 10.1016/j.conb.2008.10.001. Epub 2008 Oct 23. Curr Opin Neurobiol. 2008. PMID: 18929656 Free PMC article. Review.
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and balance. Recent studies in both lower vertebrates and mammals have uncovered genes and pathways important in hair cell develo …
The mammalian inner ear largely lacks the capacity to regenerate hair cells, the sensory cells required for hearing and …
Hair cell development.
Corwin JT, Warchol ME, Kelley MW. Corwin JT, et al. Curr Opin Neurobiol. 1993 Feb;3(1):32-7. doi: 10.1016/0959-4388(93)90032-t. Curr Opin Neurobiol. 1993. PMID: 8453286 Review.
Recent research has addressed some of these challenges at the level of cell and molecular biology, focusing on cell proliferation in hair cell epithelia, the mechanisms that control hair cell differentiation, and the developmental interde …
Recent research has addressed some of these challenges at the level of cell and molecular biology, focusing on cell proliferat …
Stem Cell-Based Hair Cell Regeneration and Therapy in the Inner Ear.
Qi J, Huang W, Lu Y, Yang X, Zhou Y, Chen T, Wang X, Yu Y, Sun JQ, Chai R. Qi J, et al. Neurosci Bull. 2024 Jan;40(1):113-126. doi: 10.1007/s12264-023-01130-w. Epub 2023 Oct 3. Neurosci Bull. 2024. PMID: 37787875 Free PMC article. Review.
Multiple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturation of newborn hair cells, and in this article, we first review the principal mechanisms underlying hair cell re …
Multiple signaling pathways and transcriptional factors trigger the activation of hair cell progenitors and ensure the maturat …
Hair Cell Transduction, Tuning, and Synaptic Transmission in the Mammalian Cochlea.
Fettiplace R. Fettiplace R. Compr Physiol. 2017 Sep 12;7(4):1197-1227. doi: 10.1002/cphy.c160049. Compr Physiol. 2017. PMID: 28915323 Free PMC article. Review.
The amplification mechanism primarily involves contractions of the outer hair cells, which are driven by changes in membrane potential and mediated by prestin, a motor protein in the outer hair cell lateral membrane. ...Genetic mutations and environmen …
The amplification mechanism primarily involves contractions of the outer hair cells, which are driven by changes in membrane p …
From Bench to Booth: Examining Hair-Cell Regeneration Through an Audiologist's Scope.
Lewis RM. Lewis RM. J Am Acad Audiol. 2021 Nov;32(10):654-660. doi: 10.1055/s-0041-1731700. Epub 2022 May 24. J Am Acad Audiol. 2021. PMID: 35609592 Review.
Damage to auditory hair cells is a key feature of sensorineural hearing loss due to aging, noise exposure, or ototoxic drugs. Though hair-cell loss is permanent in humans, research in bird species led to the discovery that analogous hair …
Damage to auditory hair cells is a key feature of sensorineural hearing loss due to aging, noise exposure, or ototoxic …
Hair cell re-growth.
Holley MC. Holley MC. Int J Pediatr Otorhinolaryngol. 2003 Dec;67 Suppl 1:S1-5. doi: 10.1016/j.ijporl.2003.08.005. Int J Pediatr Otorhinolaryngol. 2003. PMID: 14662166
These strategies are related to treatments that cause predictable damage, such as the use of aminoglycoside antibiotics. The challenge of hair cell regeneration is more difficult. Instead of preventing cell loss, we must consider methods of stimulating cel …
These strategies are related to treatments that cause predictable damage, such as the use of aminoglycoside antibiotics. The challenge of …
Hair-cell mechanotransduction and cochlear amplification.
LeMasurier M, Gillespie PG. LeMasurier M, et al. Neuron. 2005 Nov 3;48(3):403-15. doi: 10.1016/j.neuron.2005.10.017. Neuron. 2005. PMID: 16269359 Free article. Review.
In the inner ear, sensory hair cells not only detect but also amplify the softest sounds, allowing us to hear over an extraordinarily wide intensity range. This amplification is frequency specific, giving rise to exquisite frequency discrimination. Hair ce …
In the inner ear, sensory hair cells not only detect but also amplify the softest sounds, allowing us to hear over an extraord …
Mechanisms in cochlear hair cell mechano-electrical transduction for acquisition of sound frequency and intensity.
Liu S, Wang S, Zou L, Xiong W. Liu S, et al. Cell Mol Life Sci. 2021 Jun;78(12):5083-5094. doi: 10.1007/s00018-021-03840-8. Epub 2021 Apr 19. Cell Mol Life Sci. 2021. PMID: 33871677 Review.
Sound signals are acquired and digitized in the cochlea by the hair cells that further transmit the coded information to the central auditory pathways. Any defect in hair cell function may induce problems in the auditory system and hearin …
Sound signals are acquired and digitized in the cochlea by the hair cells that further transmit the coded information to the c …
Molecular basis of hair cell loss.
Furness DN. Furness DN. Cell Tissue Res. 2015 Jul;361(1):387-99. doi: 10.1007/s00441-015-2113-z. Epub 2015 Feb 13. Cell Tissue Res. 2015. PMID: 25676005 Review.
Mechanisms that lead to the death of hair cells are reviewed. Exposure to noise, the use of ototoxic drugs that damage the cochlea and old age are accompanied by hair cell death. ...However, hair cell death is sometimes produced via an ex …
Mechanisms that lead to the death of hair cells are reviewed. Exposure to noise, the use of ototoxic drugs that damage the coc …
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