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Page 1
Immunomodulatory actions of a kynurenine-derived endogenous electrophile.
Carreño M, Pires MF, Woodcock SR, Brzoska T, Ghosh S, Salvatore SR, Chang F, Khoo NKH, Dunn M, Connors N, Yuan S, Straub AC, Wendell SG, Kato GJ, Freeman BA, Ofori-Acquah SF, Sundd P, Schopfer FJ, Vitturi DA. Carreño M, et al. Sci Adv. 2022 Jul;8(26):eabm9138. doi: 10.1126/sciadv.abm9138. Epub 2022 Jun 29. Sci Adv. 2022. PMID: 35767602 Free PMC article.
Kyn-CKA induces NFE2 like bZIP transcription factor 2- and aryl hydrocarbon receptor-regulated genes and inhibits nuclear factor kappaB- and NLR family pyrin domain containing 3-dependent proinflammatory signaling. ...Both transgenic SCD mice and patients with SCD e …
Kyn-CKA induces NFE2 like bZIP transcription factor 2- and aryl hydrocarbon receptor-regulated genes and inhibits nuclear factor kapp …
Wnt5a/Ror2 promotes Nrf2-mediated tissue protective function of astrocytes after brain injury.
Endo M, Tanaka Y, Fukuoka M, Suzuki H, Minami Y. Endo M, et al. Glia. 2024 Feb;72(2):411-432. doi: 10.1002/glia.24483. Epub 2023 Oct 31. Glia. 2024. PMID: 37904612
We also found that subsequent activation of Wnt5a/Ror2 signaling in astrocytes results in nuclear accumulation of antioxidative transcription factor Nrf2 at least partly by increased expression of p62/Sqstm1, leading to promoted expression of several Nrf2 target genes, inc …
We also found that subsequent activation of Wnt5a/Ror2 signaling in astrocytes results in nuclear accumulation of antioxidative trans …
Non-coding RNAs and heme oxygenase-1 in vaccinia virus infection.
Meseda CA, Srinivasan K, Wise J, Catalano J, Yamada KM, Dhawan S. Meseda CA, et al. Biochem Biophys Res Commun. 2014 Nov 7;454(1):84-8. doi: 10.1016/j.bbrc.2014.10.035. Epub 2014 Oct 18. Biochem Biophys Res Commun. 2014. PMID: 25450361 Free PMC article.
Small nuclear RNAs (snRNAs) are <200 nucleotide non-coding uridylate-rich RNAs. ...In the present study, we demonstrate a direct correlation between expression of the cytoprotective enzyme heme oxygenase-1 (HO-1), suppression of selective snRNA expression, and inhibitio …
Small nuclear RNAs (snRNAs) are <200 nucleotide non-coding uridylate-rich RNAs. ...In the present study, we demonstrate a direct c …
FERM domain containing kindlin 1 knockdown attenuates inflammation induced by intracerebral hemorrhage in rats via NLR family pyrin domain containing 3/nuclear factor kappa B pathway.
Wei J, Yin J, Cui Y, Wang K, Hong M, Cui J. Wei J, et al. Exp Anim. 2023 Aug 7;72(3):324-335. doi: 10.1538/expanim.22-0145. Epub 2023 Feb 3. Exp Anim. 2023. PMID: 36740252 Free PMC article.
BV2 microglial cells were transfected with FERMT1 siRNA and incubated with 60 M Hemin for 24 h. Activation of NLRP3 inflammasome induced by hemin were reduced in microglia when FERMT1 was knocked down, leading to decreased production of inflammatory factors IL-1beta …
BV2 microglial cells were transfected with FERMT1 siRNA and incubated with 60 M Hemin for 24 h. Activation of NLRP3 inflammasome indu …
Evidence for a novel antioxidant function and isoform-specific regulation of the human p66Shc gene.
Miyazawa M, Tsuji Y. Miyazawa M, et al. Mol Biol Cell. 2014 Jul 1;25(13):2116-27. doi: 10.1091/mbc.E13-11-0666. Epub 2014 May 7. Mol Biol Cell. 2014. PMID: 24807908 Free PMC article.
This study provides evidence for new features of p66Shc serving as an antioxidant and critical protein in cell differentiation. Unique among the Shc family, transcription of p66Shc is activated through the antioxidant response element (ARE)-nuclear factor erythroid …
This study provides evidence for new features of p66Shc serving as an antioxidant and critical protein in cell differentiation. Unique among …
Label-free and enzyme-free colorimetric detection of microRNA by catalyzed hairpin assembly coupled with hybridization chain reaction.
Wu H, Liu Y, Wang H, Wu J, Zhu F, Zou P. Wu H, et al. Biosens Bioelectron. 2016 Jul 15;81:303-308. doi: 10.1016/j.bios.2016.03.013. Epub 2016 Mar 9. Biosens Bioelectron. 2016. PMID: 26985582
During this process, numerous split G-quadruplex structures are generated and further associate with cofactor hemin to form massive peroxidase-mimicking DNAzymes. The resulting DNAzymes catalyze the H2O2-mediated oxidation of colorless 2,2'-azino-bis(3-ethylbenzothiazoline …
During this process, numerous split G-quadruplex structures are generated and further associate with cofactor hemin to form massive p …
NLRP3 inflammasome activation in D-galactosamine and lipopolysaccharide-induced acute liver failure: role of heme oxygenase-1.
Kim SJ, Lee SM. Kim SJ, et al. Free Radic Biol Med. 2013 Dec;65:997-1004. doi: 10.1016/j.freeradbiomed.2013.08.178. Epub 2013 Aug 29. Free Radic Biol Med. 2013. PMID: 23994575
In immunoprecipitation studies, hemin attenuated the interaction of NLRP3 with ASC and caspase-1. GalN/LPS induced expression of the thioredoxin-interacting protein (TXNIP) gene and the interaction between NLRP3 and TXNIP; again, hemin attenuated these effects. The …
In immunoprecipitation studies, hemin attenuated the interaction of NLRP3 with ASC and caspase-1. GalN/LPS induced expression of the …
The ratio of SRPK1/SRPK1a regulates erythroid differentiation in K562 leukaemic cells.
Sanidas I, Kotoula V, Ritou E, Daans J, Lenz C, Mairhofer M, Daniilidou M, Kolbus A, Kruft V, Ponsaerts P, Nikolakaki E. Sanidas I, et al. Biochim Biophys Acta. 2010 Dec;1803(12):1319-31. doi: 10.1016/j.bbamcr.2010.07.008. Epub 2010 Aug 12. Biochim Biophys Acta. 2010. PMID: 20708644 Free article.
SRPK1, the prototype of the serine/arginine family of kinases, has been implicated in the regulation of multiple cellular processes such as pre-mRNA splicing, chromatin structure, nuclear import and germ cell development. ...Mass spectrometric analysis of SRPK1a-ass …
SRPK1, the prototype of the serine/arginine family of kinases, has been implicated in the regulation of multiple cellular processes s …
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1.
Ogawa K, Sun J, Taketani S, Nakajima O, Nishitani C, Sassa S, Hayashi N, Yamamoto M, Shibahara S, Fujita H, Igarashi K. Ogawa K, et al. EMBO J. 2001 Jun 1;20(11):2835-43. doi: 10.1093/emboj/20.11.2835. EMBO J. 2001. PMID: 11387216 Free PMC article.
The mammalian transcription factor Bach1 functions as a repressor of the Maf recognition element (MARE) by forming antagonizing hetero-oligomers with the small Maf family proteins. We show here that heme binds specifically to Bach1 and regulates its DNA-binding activity. . …
The mammalian transcription factor Bach1 functions as a repressor of the Maf recognition element (MARE) by forming antagonizing hetero-oligo …
[Hemin regulates the expression of nuclear factor kappa B of heme oxygenase -1 in hepatic fibrosis].
Yang H, Zhang L, Zhang XQ, Zhang XH, Zhao LF. Yang H, et al. Zhonghua Gan Zang Bing Za Zhi. 2018 Sep 20;26(9):654-659. doi: 10.3760/cma.j.issn.1007-3418.2018.09.004. Zhonghua Gan Zang Bing Za Zhi. 2018. PMID: 30481861 Chinese.
Objective: To observe the therapeutic effects and related mechanism of hemin on the progression of hepatic fibrosis in rats. Methods: Sixty male Wistar rats were randomly divided into normal control group, 4-week model group, 6-week model group, hemin inhibitor zinc …
Objective: To observe the therapeutic effects and related mechanism of hemin on the progression of hepatic fibrosis in rats. Methods: …
25 results