Immunomodulatory actions of a kynurenine-derived endogenous electrophile.
Carreño M, Pires MF, Woodcock SR, Brzoska T, Ghosh S, Salvatore SR, Chang F, Khoo NKH, Dunn M, Connors N, Yuan S, Straub AC, Wendell SG, Kato GJ, Freeman BA, Ofori-Acquah SF, Sundd P, Schopfer FJ, Vitturi DA.
Carreño M, et al.
Sci Adv. 2022 Jul;8(26):eabm9138. doi: 10.1126/sciadv.abm9138. Epub 2022 Jun 29.
Sci Adv. 2022.
PMID: 35767602
Free PMC article.
Kyn-CKA induces NFE2 like bZIP transcription factor 2- and aryl hydrocarbon receptor-regulated genes and inhibits nuclear factor kappaB- and NLR family pyrin domain containing 3-dependent proinflammatory signaling. ...Both transgenic SCD mice and patients with SCD e …
Kyn-CKA induces NFE2 like bZIP transcription factor 2- and aryl hydrocarbon receptor-regulated genes and inhibits nuclear factor kapp …