Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1.
Pan C, Cai Q, Li X, Li L, Yang L, Chen Y, Liu J, Liu W, Gao M, Sui T, Wang X, Fan H, Ruan J, Shi Y, Chen S, Cheng LS, Liu J, Yang H, Cheng G.
Pan C, et al.
Cell Mol Immunol. 2022 Apr;19(4):516-526. doi: 10.1038/s41423-021-00824-3. Epub 2022 Jan 5.
Cell Mol Immunol. 2022.
PMID: 34983952
Free PMC article.
Loss of Bach1 function not only increased HSV-1 proliferation but also promoted HSV-1-induced cell apoptosis, HMGB1 secretion, and calreticulin exposure in tumor cells. More importantly, hemin, an FDA-approved drug known to downregulate BACH1, significantly enhanced HSV-1- …
Loss of Bach1 function not only increased HSV-1 proliferation but also promoted HSV-1-induced cell apoptosis, HMGB1 secretion, and calreticu …