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1991 1
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1999 1
2002 1
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2013 2
2014 5
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2020 4
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Page 1
Cepharanthine Attenuates Early Brain Injury after Subarachnoid Hemorrhage in Mice via Inhibiting 15-Lipoxygenase-1-Mediated Microglia and Endothelial Cell Ferroptosis.
Gao S, Zhou L, Lu J, Fang Y, Wu H, Xu W, Pan Y, Wang J, Wang X, Zhang J, Shao A. Gao S, et al. Oxid Med Cell Longev. 2022 Feb 9;2022:4295208. doi: 10.1155/2022/4295208. eCollection 2022. Oxid Med Cell Longev. 2022. PMID: 35186185 Free PMC article.
METHODS: A mouse model of SAH was developed by the endovascular perforation method. bEend.3 endothelial cells and BV2 microglial cells as well as RSL3 and hemin were used to simulate SAH in vitro. Mice and cell lines were treated with CEP and a group of specific oxygenase …
METHODS: A mouse model of SAH was developed by the endovascular perforation method. bEend.3 endothelial cells and BV2 microglial cells as we …
Integrative analysis of transcriptomic and metabolomic profiles reveals abnormal phosphatidylinositol metabolism in follicles from endometriosis-associated infertility patients.
Dai Y, Lin X, Liu N, Shi L, Zhuo F, Huang Q, Gu W, Zhao F, Zhang Y, Zhang Y, Pan Y, Zhang S. Dai Y, et al. J Pathol. 2023 Jul;260(3):248-260. doi: 10.1002/path.6079. Epub 2023 Mar 29. J Pathol. 2023. PMID: 36992523
Upregulated PI and downregulated LPI correlated with oocyte retrieval number and mature oocyte number. LPI inhibited cellular reactive oxidative stress induced by hemin in granulosa cells. Cell proliferation inhibition, senescence, and apoptosis induced by hemin wer …
Upregulated PI and downregulated LPI correlated with oocyte retrieval number and mature oocyte number. LPI inhibited cellular reactive oxida …
Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1.
Pan C, Cai Q, Li X, Li L, Yang L, Chen Y, Liu J, Liu W, Gao M, Sui T, Wang X, Fan H, Ruan J, Shi Y, Chen S, Cheng LS, Liu J, Yang H, Cheng G. Pan C, et al. Cell Mol Immunol. 2022 Apr;19(4):516-526. doi: 10.1038/s41423-021-00824-3. Epub 2022 Jan 5. Cell Mol Immunol. 2022. PMID: 34983952 Free PMC article.
Loss of Bach1 function not only increased HSV-1 proliferation but also promoted HSV-1-induced cell apoptosis, HMGB1 secretion, and calreticulin exposure in tumor cells. More importantly, hemin, an FDA-approved drug known to downregulate BACH1, significantly enhanced HSV-1- …
Loss of Bach1 function not only increased HSV-1 proliferation but also promoted HSV-1-induced cell apoptosis, HMGB1 secretion, and calreticu …
Electrospinning of n-hemin/PAN Nanocomposite Membranes and Its Photo-Enhanced Enzyme-like Catalysis.
Han X, Tao Y, Xu C, Deng Y, Meng Z, Dou Z, Wang P, Feng Q. Han X, et al. Polymers (Basel). 2022 Nov 25;14(23):5135. doi: 10.3390/polym14235135. Polymers (Basel). 2022. PMID: 36501529 Free PMC article.
The kinetic studies showed that n-hemin/PAN nanocomposite membranes maintained excellent properties both in adsorption and degradation. Around 42% RhB could be adsorbed in the dark, while 91% RhB decolorized under xenon lamp irradiation in 110 min, suggesting the ca …
The kinetic studies showed that n-hemin/PAN nanocomposite membranes maintained excellent properties both in adsorption and deg …
Endogenous zinc protoporphyrin formation critically contributes to hemorrhagic stroke-induced brain damage.
Pan R, Yu S, Zhang H, Timmins GS, Weaver J, Yang Y, Zhou X, Liu KJ. Pan R, et al. J Cereb Blood Flow Metab. 2021 Dec;41(12):3232-3247. doi: 10.1177/0271678X211028475. Epub 2021 Jun 29. J Cereb Blood Flow Metab. 2021. PMID: 34187233 Free PMC article.
The causes of intracerebral hemorrhage (ICH)-induced brain damage are thought to include lysis of red blood cells, hemin release and iron overload. These mechanisms, however, have not proven very amenable to therapeutic intervention, and so other mechanistic targets are be …
The causes of intracerebral hemorrhage (ICH)-induced brain damage are thought to include lysis of red blood cells, hemin release and …
Single-Atomic Site Catalyst Enhanced Lateral Flow Immunoassay for Point-of-Care Detection of Herbicide.
Lyu Z, Ding S, Tieu P, Fang L, Li X, Li T, Pan X, Engelhard MH, Ruan X, Du D, Li S, Lin Y. Lyu Z, et al. Research (Wash D C). 2022 Aug 21;2022:9823290. doi: 10.34133/2022/9823290. eCollection 2022. Research (Wash D C). 2022. PMID: 36082212 Free PMC article.
The iron single-atomic site catalyst (Fe-SASC) is synthesized from hemin-doped ZIF-8, creating active sites that mimic the Fe active center coordination environment of natural enzyme and their functions. ...
The iron single-atomic site catalyst (Fe-SASC) is synthesized from hemin-doped ZIF-8, creating active sites that mimic the Fe active …
A programmable DNA nanodevice for colorimetric detection of DNA methyltransferase activity using functionalized hemin/G-quadruplex DNAzyme.
Yuan W, Xiao K, Liu X, Lai Y, Luo F, Xiao W, Wu J, Pan P, Li Y, Xiao H. Yuan W, et al. Anal Chim Acta. 2023 Sep 8;1273:341559. doi: 10.1016/j.aca.2023.341559. Epub 2023 Jun 23. Anal Chim Acta. 2023. PMID: 37423656
Herein, we developed a colorimetric biosensor (PER-FHGD nanodevice) to detect DNA MTase activity by integrating the primer exchange reaction (PER) amplification and functionalized hemin/G-quadruplex DNAzyme (FHGD). By replacing the native hemin cofactor into the fun …
Herein, we developed a colorimetric biosensor (PER-FHGD nanodevice) to detect DNA MTase activity by integrating the primer exchange reaction …
Ligation-Based High-Performance Mimetic Enzyme Sensing Platform for Nucleic Acid Detection.
Yan X, Yang P, Qiu D, Chen D, Pan J, Zhang X, Ju H, Zhou J. Yan X, et al. Anal Chem. 2024 Jan 9;96(1):388-393. doi: 10.1021/acs.analchem.3c04417. Epub 2023 Dec 28. Anal Chem. 2024. PMID: 38153911
G-quadruplex (G4)/hemin DNAzyme is a promising candidate to substitute horseradish peroxidase in biosensing systems, especially for the detection of nucleic acids. ...Compared with the conventional G4/hemin signaling-based method, the LCR-CPDzyme system demonstrated …
G-quadruplex (G4)/hemin DNAzyme is a promising candidate to substitute horseradish peroxidase in biosensing systems, especially for t …
Molecular domino reactor built by automated modular synthesis for cancer treatment.
Yang Y, He J, Zhu W, Pan X, Yazd HS, Cui C, Yang L, Li X, Li L, Cheng L, Feng L, Wang R, Liu Z, Chen M, Tan W. Yang Y, et al. Theranostics. 2020 Mar 4;10(9):4030-4041. doi: 10.7150/thno.43581. eCollection 2020. Theranostics. 2020. PMID: 32226537 Free PMC article.
The engineering of this reactor takes advantage of the well-established solid-phase synthesis platform to incorporate a photosensitizer into G-quadruplex/ hemin DNAzyme at the molecular level. Results: As a proof of concept, our photodynamic domino reactor, termed AS1411/ …
The engineering of this reactor takes advantage of the well-established solid-phase synthesis platform to incorporate a photosensitizer into …
50 results