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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 1
1981 1
1982 2
1988 1
1989 2
1991 2
1992 2
1993 1
1994 4
1996 1
1997 4
1998 3
1999 3
2000 3
2001 4
2002 4
2003 7
2004 11
2005 5
2006 10
2007 11
2008 8
2009 8
2010 7
2011 12
2012 10
2013 24
2014 28
2015 36
2016 31
2017 32
2018 42
2019 36
2020 35
2021 42
2022 54
2023 56
2024 28

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499 results

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Page 1
Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria.
Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, Bissell DM, Bonkovsky HL, Windyga J, Anderson KE, Parker C, Silver SM, Keel SB, Wang JD, Stein PE, Harper P, Vassiliou D, Wang B, Phillips J, Ivanova A, Langendonk JG, Kauppinen R, Minder E, Horie Y, Penz C, Chen J, Liu S, Ko JJ, Sweetser MT, Garg P, Vaishnaw A, Kim JB, Simon AR, Gouya L; ENVISION Investigators. Balwani M, et al. N Engl J Med. 2020 Jun 11;382(24):2289-2301. doi: 10.1056/NEJMoa1913147. N Engl J Med. 2020. PMID: 32521132 Clinical Trial.
(Composite porphyria attacks resulted in hospitalization, an urgent health care visit, or intravenous administration of hemin at home.) Key secondary end points were levels of ALA and porphobilinogen and the annualized attack rate among patients with acute hepatic porphyri …
(Composite porphyria attacks resulted in hospitalization, an urgent health care visit, or intravenous administration of hemin at home …
Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling.
Yu H, Cao X, Li W, Liu P, Zhao Y, Song L, Chen J, Chen B, Yu W, Xu Y. Yu H, et al. J Neuroinflammation. 2020 Oct 28;17(1):322. doi: 10.1186/s12974-020-01978-z. J Neuroinflammation. 2020. PMID: 33115476 Free PMC article.
However, the role of excessive Cx43Hc opening in intracerebral hemorrhage (ICH) injury is not clear. METHODS: Hemin stimulation in primary cells and collagenase IV injection in C57BL/6J (B6) mice were used as ICH models in vitro and in vivo. ...Intriguingly, Cx43 transcrip …
However, the role of excessive Cx43Hc opening in intracerebral hemorrhage (ICH) injury is not clear. METHODS: Hemin stimulation in pr …
The BACH1 inhibitor ASP8731 inhibits inflammation and vaso-occlusion and induces fetal hemoglobin in sickle cell disease.
Belcher JD, Nataraja S, Abdulla F, Zhang P, Chen C, Nguyen J, Ruan C, Singh M, Demes S, Olson L, Stickens D, Stanwix J, Clarke E, Huang Y, Biddle M, Vercellotti GM. Belcher JD, et al. Front Med (Lausanne). 2023 Apr 18;10:1101501. doi: 10.3389/fmed.2023.1101501. eCollection 2023. Front Med (Lausanne). 2023. PMID: 37144034 Free PMC article.
In pulmonary endothelial cells, ASP8731 decreased VCAM1 mRNA in response to TNF-alpha and blocked a decrease in glutathione in response to hemin. Townes-SS mice were gavaged once per day for 4 weeks with ASP8731, hydroxyurea (HU) or vehicle. ...
In pulmonary endothelial cells, ASP8731 decreased VCAM1 mRNA in response to TNF-alpha and blocked a decrease in glutathione in response to …
Enhancing the HSV-1-mediated antitumor immune response by suppressing Bach1.
Pan C, Cai Q, Li X, Li L, Yang L, Chen Y, Liu J, Liu W, Gao M, Sui T, Wang X, Fan H, Ruan J, Shi Y, Chen S, Cheng LS, Liu J, Yang H, Cheng G. Pan C, et al. Cell Mol Immunol. 2022 Apr;19(4):516-526. doi: 10.1038/s41423-021-00824-3. Epub 2022 Jan 5. Cell Mol Immunol. 2022. PMID: 34983952 Free PMC article.
Loss of Bach1 function not only increased HSV-1 proliferation but also promoted HSV-1-induced cell apoptosis, HMGB1 secretion, and calreticulin exposure in tumor cells. More importantly, hemin, an FDA-approved drug known to downregulate BACH1, significantly enhanced HSV-1- …
Loss of Bach1 function not only increased HSV-1 proliferation but also promoted HSV-1-induced cell apoptosis, HMGB1 secretion, and calreticu …
Mitochondrial Inhibitor Rotenone Triggers and Enhances Neuronal Ferroptosis Following Intracerebral Hemorrhage.
Cheng Y, Zhang Z, Tang H, Chen B, Cai Y, Wei Y, Zhao W, Wu ZB, Shang H. Cheng Y, et al. ACS Chem Neurosci. 2023 Mar 15;14(6):1071-1079. doi: 10.1021/acschemneuro.2c00308. Epub 2023 Feb 27. ACS Chem Neurosci. 2023. PMID: 36848438
Single Rot administration markedly inhibited neuronal viability, promoted iron accumulation, increased malondialdehyde (MDA) contents, decreased total superoxide dismutase (SOD) activity, and downregulated ferroptosis-related proteins RPL8, COX-2, xCT, ASCL4, and GPX4 in primary …
Single Rot administration markedly inhibited neuronal viability, promoted iron accumulation, increased malondialdehyde (MDA) contents, decre …
Withaferin A inhibits ferroptosis and protects against intracerebral hemorrhage.
Zhou ZX, Cui Q, Zhang YM, Yang JX, Xiang WJ, Tian N, Jiang YL, Chen ML, Yang B, Li QH, Liao RJ. Zhou ZX, et al. Neural Regen Res. 2023 Jun;18(6):1308-1315. doi: 10.4103/1673-5374.355822. Neural Regen Res. 2023. PMID: 36453416 Free PMC article.
We established a mouse model of ICH by injection of autologous tail artery blood into the caudate nucleus and an in vitro cell model of hemin-induced ICH. WFA was injected intracerebroventricularly at 0.1, 1 or 5 g/kg once daily for 7 days, starting immediately after ICH o …
We established a mouse model of ICH by injection of autologous tail artery blood into the caudate nucleus and an in vitro cell model of h …
Netrin-1 Alleviates Early Brain Injury by Regulating Ferroptosis via the PPARγ/Nrf2/GPX4 Signaling Pathway Following Subarachnoid Hemorrhage.
Chen J, Wang Y, Li M, Zhu X, Liu Z, Chen Q, Xiong K. Chen J, et al. Transl Stroke Res. 2024 Feb;15(1):219-237. doi: 10.1007/s12975-022-01122-4. Epub 2023 Jan 12. Transl Stroke Res. 2024. PMID: 36631632
This study aimed to evaluate the neuroprotective effects and the possible molecular basis of NTN-1 in SAH-induced EBI by modulating neuronal ferroptosis using the filament perforations model of SAH in mice and the hemin-stimulated neuron injury model in HT22 cells. NTN-1 o …
This study aimed to evaluate the neuroprotective effects and the possible molecular basis of NTN-1 in SAH-induced EBI by modulating neuronal …
Selective HDAC6 inhibition protects against blood-brain barrier dysfunction after intracerebral hemorrhage.
Peng C, Wang Y, Hu Z, Chen C. Peng C, et al. CNS Neurosci Ther. 2024 Mar;30(3):e14429. doi: 10.1111/cns.14429. Epub 2023 Sep 4. CNS Neurosci Ther. 2024. PMID: 37665135 Free PMC article.
However, the role of HDAC6 inhibition on ICH-induced BBB disruption remains unknown. METHODS: Hemin-induced human brain microvascular endothelial cells (HBMECs) and collagenase-induced rats were employed to investigated the underlying impact of the HDAC6 inhibition in BBB …
However, the role of HDAC6 inhibition on ICH-induced BBB disruption remains unknown. METHODS: Hemin-induced human brain microvascular …
An oxidatively damaged G-quadruplex/hemin DNAzyme.
Wang J, Cheng M, Chen J, Ju H, Monchaud D, Mergny JL, Zhou J. Wang J, et al. Chem Commun (Camb). 2020 Feb 11;56(12):1839-1842. doi: 10.1039/c9cc09237d. Epub 2020 Jan 17. Chem Commun (Camb). 2020. PMID: 31950946
Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides clues to the mechanistic origins of DNAzyme deactivation, which originates from an interplay between decreased G-quadruplex stability, lower …
Oxidative damage of guanine to 8-oxoguanine triggers a partial and variable loss of G-quadruplex/hemin DNAzyme activity and provides …
Fighting cancer by triggering non-canonical mitochondrial permeability transition-driven necrosis through reactive oxygen species induction.
Xiao Q, Zhong B, Hou Y, Wang M, Guo B, Lin L, Zhou Y, Chen X. Xiao Q, et al. Free Radic Biol Med. 2023 Jun;202:35-45. doi: 10.1016/j.freeradbiomed.2023.03.020. Epub 2023 Mar 23. Free Radic Biol Med. 2023. PMID: 36963639
IBC-triggered cell death could be remarkably reversed by the ROS scavengers, cyclosporin A (CsA) and hemin, whereas CypD silence and heme oxygenase-1 overexpression failed to do so. ...
IBC-triggered cell death could be remarkably reversed by the ROS scavengers, cyclosporin A (CsA) and hemin, whereas CypD silence and …
499 results