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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1980 2
1981 3
1982 1
1983 1
1984 1
1986 2
1987 4
1988 2
1989 3
1990 7
1991 5
1992 11
1993 10
1994 6
1995 19
1996 15
1997 11
1998 26
1999 19
2000 25
2001 29
2002 30
2003 36
2004 57
2005 53
2006 80
2007 110
2008 126
2009 139
2010 152
2011 199
2012 253
2013 269
2014 323
2015 386
2016 442
2017 515
2018 625
2019 720
2020 937
2021 1110
2022 1384
2023 1361
2024 585

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8,952 results

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Page 1
Showing results for guiding, lin
Search for guiting, lin instead (1 results)
Multiplex genome engineering using CRISPR/Cas systems.
Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, Hsu PD, Wu X, Jiang W, Marraffini LA, Zhang F. Cong L, et al. Science. 2013 Feb 15;339(6121):819-23. doi: 10.1126/science.1231143. Epub 2013 Jan 3. Science. 2013. PMID: 23287718 Free PMC article.
The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to facilitate RNA-guided site-specific DNA cleavage. We engineered two different type II CRISPR/Cas systems and demonstrate that Cas9 nuclea …
The type II prokaryotic CRISPR (clustered regularly interspaced short palindromic repeats)/Cas adaptive immune system has been shown to faci …
Functional Dental Pulp Regeneration: Basic Research and Clinical Translation.
Xie Z, Shen Z, Zhan P, Yang J, Huang Q, Huang S, Chen L, Lin Z. Xie Z, et al. Int J Mol Sci. 2021 Aug 20;22(16):8991. doi: 10.3390/ijms22168991. Int J Mol Sci. 2021. PMID: 34445703 Free PMC article. Review.
Finally, we summarised the current challenges encountered in preclinical or clinical regenerative applications and suggested promising solutions to address these challenges to guide tissue engineering-mediated clinical translation in the future....
Finally, we summarised the current challenges encountered in preclinical or clinical regenerative applications and suggested promising solut …
Molecular genetics of β-thalassemia: A narrative review.
Jaing TH, Chang TY, Chen SH, Lin CW, Wen YC, Chiu CC. Jaing TH, et al. Medicine (Baltimore). 2021 Nov 12;100(45):e27522. doi: 10.1097/MD.0000000000027522. Medicine (Baltimore). 2021. PMID: 34766559 Free PMC article. Review.
However, the generation of an additive composite genetic risk score predicts prognosis, and guide management requires a larger panel of genetic modifiers yet to be discovered.Presently, using data from prior clinical trials guides the design of further research and …
However, the generation of an additive composite genetic risk score predicts prognosis, and guide management requires a larger panel …
RNA-programmed genome editing in human cells.
Jinek M, East A, Cheng A, Lin S, Ma E, Doudna J. Jinek M, et al. Elife. 2013 Jan 29;2:e00471. doi: 10.7554/eLife.00471. Elife. 2013. PMID: 23386978 Free PMC article.
Type II CRISPR immune systems in bacteria use a dual RNA-guided DNA endonuclease, Cas9, to cleave foreign DNA at specific sites. We show here that Cas9 assembles with hybrid guide RNAs in human cells and can induce the formation of double-strand DNA breaks (DSBs) at …
Type II CRISPR immune systems in bacteria use a dual RNA-guided DNA endonuclease, Cas9, to cleave foreign DNA at specific sites. We s …
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.
Ran FA, Hsu PD, Lin CY, Gootenberg JS, Konermann S, Trevino AE, Scott DA, Inoue A, Matoba S, Zhang Y, Zhang F. Ran FA, et al. Cell. 2013 Sep 12;154(6):1380-9. doi: 10.1016/j.cell.2013.08.021. Epub 2013 Aug 29. Cell. 2013. PMID: 23992846 Free PMC article.
The Cas9 nuclease from the microbial CRISPR-Cas system is targeted to specific genomic loci by a 20 nt guide sequence, which can tolerate certain mismatches to the DNA target and thereby promote undesired off-target mutagenesis. Here, we describe an approach that combines …
The Cas9 nuclease from the microbial CRISPR-Cas system is targeted to specific genomic loci by a 20 nt guide sequence, which can tole …
Generation of CRISPR-Cas9-mediated genetic knockout human intestinal tissue-derived enteroid lines by lentivirus transduction and single-cell cloning.
Lin SC, Haga K, Zeng XL, Estes MK. Lin SC, et al. Nat Protoc. 2022 Apr;17(4):1004-1027. doi: 10.1038/s41596-021-00669-0. Epub 2022 Feb 23. Nat Protoc. 2022. PMID: 35197604 Free PMC article. Review.
This protocol differs from a previously published alternative using electroporation of human colonoids to deliver piggyback transposons or CRISPR-Cas9 constructs, as this protocol uses a modified, fused LentiCRISPRv2-small-guiding RNA to express Cas9 and small-guiding …
This protocol differs from a previously published alternative using electroporation of human colonoids to deliver piggyback transposons or C …
Caudal Epidural Block: An Updated Review of Anatomy and Techniques.
Kao SC, Lin CS. Kao SC, et al. Biomed Res Int. 2017;2017:9217145. doi: 10.1155/2017/9217145. Epub 2017 Feb 26. Biomed Res Int. 2017. PMID: 28337460 Free PMC article. Review.
This high failure rate could be attributed to anatomic variations that make locating sacral hiatus difficult. With the advent of fluoroscopy and ultrasound in guiding needle placement, the success rate of caudal epidural block has been markedly improved. Although fluorosco …
This high failure rate could be attributed to anatomic variations that make locating sacral hiatus difficult. With the advent of fluoroscopy …
Structures of Cas9 endonucleases reveal RNA-mediated conformational activation.
Jinek M, Jiang F, Taylor DW, Sternberg SH, Kaya E, Ma E, Anders C, Hauer M, Zhou K, Lin S, Kaplan M, Iavarone AT, Charpentier E, Nogales E, Doudna JA. Jinek M, et al. Science. 2014 Mar 14;343(6176):1247997. doi: 10.1126/science.1247997. Epub 2014 Feb 6. Science. 2014. PMID: 24505130 Free PMC article.
Type II CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems use an RNA-guided DNA endonuclease, Cas9, to generate double-strand breaks in invasive DNA during an adaptive bacterial immune response. ...The observation that exten …
Type II CRISPR (clustered regularly interspaced short palindromic repeats)-Cas (CRISPR-associated) systems use an RNA-guided DNA endo …
Learning styles, preferences and needs of generation Z healthcare students: Scoping review.
Shorey S, Chan V, Rajendran P, Ang E. Shorey S, et al. Nurse Educ Pract. 2021 Nov;57:103247. doi: 10.1016/j.nepr.2021.103247. Epub 2021 Oct 26. Nurse Educ Pract. 2021. PMID: 34768214 Review.
The Arksey and O'Malley (2005) five-stage framework was adopted to guide this review: (1) identifying the research question; (2) identifying relevant studies; (3) study selection; (4) charting the data; and (5) collating, summarising and reporting the results using a thema …
The Arksey and O'Malley (2005) five-stage framework was adopted to guide this review: (1) identifying the research question; (2) iden …
Perceptual inference.
Aggelopoulos NC. Aggelopoulos NC. Neurosci Biobehav Rev. 2015 Aug;55:375-92. doi: 10.1016/j.neubiorev.2015.05.001. Epub 2015 May 11. Neurosci Biobehav Rev. 2015. PMID: 25976632 Review.
Methods of Bayesian statistical inference and decision theory model cognition adequately by using error sensing either in guiding action or in "generative" models that predict the sensory information. In this framework, perception can be seen as a process qualitatively dis …
Methods of Bayesian statistical inference and decision theory model cognition adequately by using error sensing either in guiding act …
8,952 results