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Year Number of Results
1987 1
1989 1
1990 1
1992 2
1994 4
1995 1
1996 7
1997 8
1998 3
1999 4
2000 6
2001 6
2002 13
2003 24
2004 20
2005 39
2006 50
2007 56
2008 78
2009 100
2010 126
2011 139
2012 176
2013 219
2014 308
2015 379
2016 428
2017 521
2018 633
2019 783
2020 1036
2021 1266
2022 1616
2023 1839
2024 778

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9,609 results

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Page 1
An engineered hypercompact CRISPR-Cas12f system with boosted gene-editing activity.
Wu T, Liu C, Zou S, Lyu R, Yang B, Yan H, Zhao M, Tang W. Wu T, et al. Nat Chem Biol. 2023 Nov;19(11):1384-1393. doi: 10.1038/s41589-023-01380-9. Epub 2023 Jul 3. Nat Chem Biol. 2023. PMID: 37400536 Free PMC article.
Compact CRISPR-Cas systems offer versatile treatment options for genetic disorders, but their application is often limited by modest gene-editing activity. Here we present enAsCas12f, an engineered RNA-guided DNA endonuclease up to 11.3-fold more potent than its parent pro …
Compact CRISPR-Cas systems offer versatile treatment options for genetic disorders, but their application is often limited by modest gene-ed …
Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity.
Tsuchida CA, Zhang S, Doost MS, Zhao Y, Wang J, O'Brien E, Fang H, Li CP, Li D, Hai ZY, Chuck J, Brötzmann J, Vartoumian A, Burstein D, Chen XW, Nogales E, Doudna JA, Liu JG. Tsuchida CA, et al. Mol Cell. 2022 Mar 17;82(6):1199-1209.e6. doi: 10.1016/j.molcel.2022.02.002. Epub 2022 Feb 25. Mol Cell. 2022. PMID: 35219382 Free PMC article.
A compact protein with a size of <1,000 amino acids, the CRISPR-associated protein CasX is a fundamentally distinct RNA-guided nuclease when compared to Cas9 and Cas12a. Although it can induce RNA-guided genome editing in mammalian cells, the activity of CasX is …
A compact protein with a size of <1,000 amino acids, the CRISPR-associated protein CasX is a fundamentally distinct RNA-guided nuc …
HERB: a high-throughput experiment- and reference-guided database of traditional Chinese medicine.
Fang S, Dong L, Liu L, Guo J, Zhao L, Zhang J, Bu D, Liu X, Huo P, Cao W, Dong Q, Wu J, Zeng X, Wu Y, Zhao Y. Fang S, et al. Nucleic Acids Res. 2021 Jan 8;49(D1):D1197-D1206. doi: 10.1093/nar/gkaa1063. Nucleic Acids Res. 2021. PMID: 33264402 Free PMC article.
Therefore, we built HERB, a high-throughput experiment- and reference-guided database of TCM, with its Chinese name as BenCaoZuJian. We re-analyzed 6164 gene expression profiles from 1037 high-throughput experiments evaluating TCM herbs/ingredients, and generated connectio …
Therefore, we built HERB, a high-throughput experiment- and reference-guided database of TCM, with its Chinese name as BenCaoZuJian. …
AI-Augmented Images for X-Ray Guiding Radiation Therapy Delivery.
Niu T, Tsui T, Zhao W. Niu T, et al. Semin Radiat Oncol. 2022 Oct;32(4):365-376. doi: 10.1016/j.semradonc.2022.06.006. Semin Radiat Oncol. 2022. PMID: 36202439 Review.
With advancing radiation treatment technology, better imaging techniques are imperative for safe, high-dose delivery. Artificial intelligence developments on image-guided radiation therapy technologies, which range from Kilovoltage and Megavoltage modalities to two-dimensi …
With advancing radiation treatment technology, better imaging techniques are imperative for safe, high-dose delivery. Artificial intelligenc …
Topographic Cues Guiding Cell Polarization via Distinct Cellular Mechanosensing Pathways.
Liu W, Sun Q, Zheng ZL, Gao YT, Zhu GY, Wei Q, Xu JZ, Li ZM, Zhao CS. Liu W, et al. Small. 2022 Jan;18(2):e2104328. doi: 10.1002/smll.202104328. Epub 2021 Nov 5. Small. 2022. PMID: 34738726 Review.
Space constraint (spatially limiting cell extension) and adhesion induction (guiding adhesome growth) are two main ways to induce cell polarization according to the microenvironment topographies. However, the mechanism of cell polarization induced by these two ways and the …
Space constraint (spatially limiting cell extension) and adhesion induction (guiding adhesome growth) are two main ways to induce cel …
Expert consensus on digital guided therapy for endodontic diseases.
Wei X, Du Y, Zhou X, Yue L, Yu Q, Hou B, Chen Z, Liang J, Chen W, Qiu L, Huang X, Meng L, Huang D, Wang X, Tian Y, Tang Z, Zhang Q, Miao L, Zhao J, Yang D, Yang J, Ling J. Wei X, et al. Int J Oral Sci. 2023 Dec 6;15(1):54. doi: 10.1038/s41368-023-00261-0. Int J Oral Sci. 2023. PMID: 38052782 Free PMC article. Review.
Digital guided therapy (DGT) has been advocated as a contemporary computer-aided technique for treating endodontic diseases in recent decades. The concept of DGT for endodontic diseases is categorized into static guided endodontics (SGE), necessitating a meticulousl …
Digital guided therapy (DGT) has been advocated as a contemporary computer-aided technique for treating endodontic diseases in recent …
Additive Manufacturing in Orthopedics: A Review.
Zhao Y, Wang Z, Zhao J, Hussain M, Wang M. Zhao Y, et al. ACS Biomater Sci Eng. 2022 Apr 11;8(4):1367-1380. doi: 10.1021/acsbiomaterials.1c01072. Epub 2022 Mar 10. ACS Biomater Sci Eng. 2022. PMID: 35266709 Review.
This Review lists the recent research results, analyzes the strengths and weaknesses of diverse three-dimensional printing strategies in orthopedics, and sums up the use of varying 3D printing strategies in surgical guides, surgical implants, surgical predictive models, an …
This Review lists the recent research results, analyzes the strengths and weaknesses of diverse three-dimensional printing strategies in ort …
Base editing of the mutated TERT promoter inhibits liver tumor growth.
Zhao G, Ma Q, Yang H, Jiang H, Xu Q, Luo S, Meng Z, Liu J, Zhu L, Lin Q, Li M, Fang J, Ma L, Qiu W, Mao Z, Lu Z. Zhao G, et al. Hepatology. 2023 Nov 28. doi: 10.1097/HEP.0000000000000700. Online ahead of print. Hepatology. 2023. PMID: 38016019
The mutated TERT promoter -124 C>T is corrected to -124 C by a single guide (sg) RNA-guided and deactivated Campylobacter jejuni Cas9 (CjCas9)-fused adenine base editor (CjABE). ...Importantly, injection of adeno-associated viruses expressing sgRNA-guided …
The mutated TERT promoter -124 C>T is corrected to -124 C by a single guide (sg) RNA-guided and deactivated Campylobacter j …
Guiding Principles for Designing Highly Efficient Metal-Free Carbon Catalysts.
Zhang L, Lin CY, Zhang D, Gong L, Zhu Y, Zhao Z, Xu Q, Li H, Xia Z. Zhang L, et al. Adv Mater. 2019 Mar;31(13):e1805252. doi: 10.1002/adma.201805252. Epub 2018 Dec 7. Adv Mater. 2019. PMID: 30536475 Review.
These reactions include the oxygen reduction reaction in fuel cells, the oxygen evolution reaction in metal-air batteries, the iodine reduction reaction in dye-sensitized solar cells, the hydrogen evolution reaction in water splitting, and the carbon dioxide reduction in artifici …
These reactions include the oxygen reduction reaction in fuel cells, the oxygen evolution reaction in metal-air batteries, the iodine reduct …
[Application of PET-LINAC in Biology-guided Radiotherapy].
Yang X, Zhao W, Tian X, Cai J, Xie S, Liu Q, Peng H, Peng Q. Yang X, et al. Zhongguo Yi Liao Qi Xie Za Zhi. 2023 May 30;47(3):237-241. doi: 10.3969/j.issn.1671-7104.2023.03.001. Zhongguo Yi Liao Qi Xie Za Zhi. 2023. PMID: 37288620 Review. Chinese.
Biology-guided radiotherapy (BgRT) is a novel technique of external beam radiotherapy, combining positron emission tomography-computed tomography (PET-CT) with a linear accelerator (LINAC). ...RefleXion Medical has developed the world's first BgRT system. Nevertheless, its …
Biology-guided radiotherapy (BgRT) is a novel technique of external beam radiotherapy, combining positron emission tomography-compute …
9,609 results