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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1978 1
1984 1
1989 1
1992 3
1993 1
1995 3
1996 2
1998 2
1999 3
2000 3
2001 5
2002 4
2003 6
2004 8
2005 12
2006 8
2007 13
2008 19
2009 16
2010 15
2011 23
2012 25
2013 45
2014 61
2015 62
2016 75
2017 99
2018 114
2019 134
2020 168
2021 210
2022 299
2023 314
2024 149

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1,701 results

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Page 1
Molecular genetics of β-thalassemia: A narrative review.
Jaing TH, Chang TY, Chen SH, Lin CW, Wen YC, Chiu CC. Jaing TH, et al. Medicine (Baltimore). 2021 Nov 12;100(45):e27522. doi: 10.1097/MD.0000000000027522. Medicine (Baltimore). 2021. PMID: 34766559 Free PMC article. Review.
However, the generation of an additive composite genetic risk score predicts prognosis, and guide management requires a larger panel of genetic modifiers yet to be discovered.Presently, using data from prior clinical trials guides the design of further research and …
However, the generation of an additive composite genetic risk score predicts prognosis, and guide management requires a larger panel …
The clinical management of hepatocellular carcinoma worldwide: A concise review and comparison of current guidelines: 2022 update.
Wen N, Cai Y, Li F, Ye H, Tang W, Song P, Cheng N. Wen N, et al. Biosci Trends. 2022 Mar 11;16(1):20-30. doi: 10.5582/bst.2022.01061. Epub 2022 Feb 24. Biosci Trends. 2022. PMID: 35197399 Free article. Review.
However, further studies are needed to improve the management and outcomes of HCC. More straightforward or refined guidelines would help guide doctors to make better decisions in the treatment of HCC in the future....
However, further studies are needed to improve the management and outcomes of HCC. More straightforward or refined guidelines would help …
The miniature CRISPR-Cas12m effector binds DNA to block transcription.
Wu WY, Mohanraju P, Liao C, Adiego-Pérez B, Creutzburg SCA, Makarova KS, Keessen K, Lindeboom TA, Khan TS, Prinsen S, Joosten R, Yan WX, Migur A, Laffeber C, Scott DA, Lebbink JHG, Koonin EV, Beisel CL, van der Oost J. Wu WY, et al. Mol Cell. 2022 Dec 1;82(23):4487-4502.e7. doi: 10.1016/j.molcel.2022.11.003. Epub 2022 Nov 24. Mol Cell. 2022. PMID: 36427491 Free article.
CRISPR-Cas are prokaryotic adaptive immune systems. Cas nucleases generally use CRISPR-derived RNA guides to specifically bind and cleave DNA or RNA targets. Here, we describe the experimental characterization of a bacterial CRISPR effector protein Cas12m representing subt …
CRISPR-Cas are prokaryotic adaptive immune systems. Cas nucleases generally use CRISPR-derived RNA guides to specifically bind and cl …
Single-cell RNA-sequencing reveals heterogeneity and intercellular crosstalk in human tuberculosis lung.
Wang L, Ma H, Wen Z, Niu L, Chen X, Liu H, Zhang S, Xu J, Zhu Y, Li H, Chen H, Shi L, Wan L, Li L, Li M, Wong KW, Song Y. Wang L, et al. J Infect. 2023 Nov;87(5):373-384. doi: 10.1016/j.jinf.2023.09.004. Epub 2023 Sep 9. J Infect. 2023. PMID: 37690670 Free article.
Our analysis provides insights into the transcriptomic heterogeneity and cellular crosstalk in pulmonary tuberculosis and guides unveiling cellular and molecular targets for tuberculosis therapy....
Our analysis provides insights into the transcriptomic heterogeneity and cellular crosstalk in pulmonary tuberculosis and guides unve …
A split prime editor with untethered reverse transcriptase and circular RNA template.
Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodríguez TC, Liang SQ, Xue W, Sontheimer EJ. Liu B, et al. Nat Biotechnol. 2022 Sep;40(9):1388-1393. doi: 10.1038/s41587-022-01255-9. Epub 2022 Apr 4. Nat Biotechnol. 2022. PMID: 35379962
Delivery with two adeno-associated virus (AAV) vectors corrected the disease-causing mutation in a mouse model of type I tyrosinemia. Similarly, prime editing guide RNAs (pegRNAs) can be split into a single guide RNA (sgRNA) and a circular RNA RT template to increas …
Delivery with two adeno-associated virus (AAV) vectors corrected the disease-causing mutation in a mouse model of type I tyrosinemia. Simila …
Deletion and replacement of long genomic sequences using prime editing.
Jiang T, Zhang XO, Weng Z, Xue W. Jiang T, et al. Nat Biotechnol. 2022 Feb;40(2):227-234. doi: 10.1038/s41587-021-01026-y. Epub 2021 Oct 14. Nat Biotechnol. 2022. PMID: 34650270 Free PMC article.
By conjugating Cas9 nuclease to reverse transcriptase (PE-Cas9) and combining it with two PE guide RNAs (pegRNAs) targeting complementary DNA strands, we achieve precise and specific deletion and repair of target sequences via using this PE-Cas9-based deletion and repair ( …
By conjugating Cas9 nuclease to reverse transcriptase (PE-Cas9) and combining it with two PE guide RNAs (pegRNAs) targeting complemen …
Osteoclast-targeted delivery of anti-miRNA oligonucleotides by red blood cell extracellular vesicles.
Xu L, Xu X, Liang Y, Wen C, Ouyang K, Huang J, Xiao Y, Deng X, Xia J, Duan L. Xu L, et al. J Control Release. 2023 Jun;358:259-272. doi: 10.1016/j.jconrel.2023.04.043. Epub 2023 May 5. J Control Release. 2023. PMID: 37121514
A bi-functional peptide, TBP-CP05, which binds to both the CD63 on RBCEVs and receptors on osteoclasts, acts as the guide. TBP-CP05 binds with RBCEVs through CP05, displays the TRAP-binding peptide (TBP) on the surface of EVs, and endows RBCEVs with osteoclast-targeting ca …
A bi-functional peptide, TBP-CP05, which binds to both the CD63 on RBCEVs and receptors on osteoclasts, acts as the guide. TBP-CP05 b …
Epidermoid Cyst.
Zito PM, Scharf R. Zito PM, et al. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 29763149 Free Books & Documents.
Epidermoid cyst, also known as a sebaceous cyst, is a benign encapsulated, subepidermal nodule filled with keratin material. ...Epidermoid cysts develop within the infundibulum. Other common synonyms include infundibular cyst, epidermal cyst, an …
Epidermoid cyst, also known as a sebaceous cyst, is a benign encapsulated, subepidermal nodule filled with keratin material. . …
Epidermal Inclusion Cyst.
Weir CB, St.Hilaire NJ. Weir CB, et al. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Aug 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 30335343 Free Books & Documents.
Epidermal inclusion cysts are the most common cutaneous cysts. Numerous synonyms for epidermal inclusion cysts exist, including epidermoid cyst, epidermal cyst, infundibular cyst, inclusion cyst, and keratin cyst. ...They al …
Epidermal inclusion cysts are the most common cutaneous cysts. Numerous synonyms for epidermal inclusion cysts exist, includin …
Benign Eyelid Lesions.
Stokkermans TJ, Prendes M. Stokkermans TJ, et al. 2023 May 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 May 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 35881760 Free Books & Documents.
Benign neoplastic lesions include squamous cell papilloma, epidermal inclusion cyst, dermoid/epidermoid cyst, acquired melanocytic nevus, seborrheic keratosis, hidrocystoma, cyst of Zeiss, and xanthelasma. ...
Benign neoplastic lesions include squamous cell papilloma, epidermal inclusion cyst, dermoid/epidermoid cyst, acquired …
1,701 results