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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1987 1
1992 1
1996 1
1997 1
1998 3
1999 3
2000 3
2001 2
2002 2
2003 4
2004 16
2005 15
2006 16
2007 17
2008 29
2009 28
2010 31
2011 32
2012 53
2013 62
2014 85
2015 100
2016 130
2017 155
2018 178
2019 201
2020 273
2021 353
2022 463
2023 451
2024 219

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2,651 results

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Page 1
Patient-derived micro-organospheres enable clinical precision oncology.
Ding S, Hsu C, Wang Z, Natesh NR, Millen R, Negrete M, Giroux N, Rivera GO, Dohlman A, Bose S, Rotstein T, Spiller K, Yeung A, Sun Z, Jiang C, Xi R, Wilkin B, Randon PM, Williamson I, Nelson DA, Delubac D, Oh S, Rupprecht G, Isaacs J, Jia J, Chen C, Shen JP, Kopetz S, McCall S, Smith A, Gjorevski N, Walz AC, Antonia S, Marrer-Berger E, Clevers H, Hsu D, Shen X. Ding S, et al. Cell Stem Cell. 2022 Jun 2;29(6):905-917.e6. doi: 10.1016/j.stem.2022.04.006. Epub 2022 May 3. Cell Stem Cell. 2022. PMID: 35508177 Free PMC article.
Patient-derived xenografts (PDXs) and patient-derived organoids (PDOs) have been shown to model clinical response to cancer therapy. However, it remains challenging to use these models to guide timely clinical decisions for cancer patients. Here, we used droplet emulsion m …
Patient-derived xenografts (PDXs) and patient-derived organoids (PDOs) have been shown to model clinical response to cancer therapy. However …
Craspase is a CRISPR RNA-guided, RNA-activated protease.
Hu C, van Beljouw SPB, Nam KH, Schuler G, Ding F, Cui Y, Rodríguez-Molina A, Haagsma AC, Valk M, Pabst M, Brouns SJJ, Ke A. Hu C, et al. Science. 2022 Sep 16;377(6612):1278-1285. doi: 10.1126/science.add5064. Epub 2022 Aug 25. Science. 2022. PMID: 36007061 Free PMC article.
The CRISPR-Cas type III-E RNA-targeting effector complex gRAMP/Cas7-11 is associated with a caspase-like protein (TPR-CHAT/Csx29) to form Craspase (CRISPR-guided caspase). Here, we use cryo-electron microscopy snapshots of Craspase to explain its target RNA cleavage and pr …
The CRISPR-Cas type III-E RNA-targeting effector complex gRAMP/Cas7-11 is associated with a caspase-like protein (TPR-CHAT/Csx29) to form Cr …
Phase separation of EB1 guides microtubule plus-end dynamics.
Song X, Yang F, Yang T, Wang Y, Ding M, Li L, Xu P, Liu S, Dai M, Chi C, Xiang S, Xu C, Li D, Wang Z, Li L, Hill DL, Fu C, Yuan K, Li P, Zang J, Hou Z, Jiang K, Shi Y, Liu X, Yao X. Song X, et al. Nat Cell Biol. 2023 Jan;25(1):79-91. doi: 10.1038/s41556-022-01033-4. Epub 2022 Dec 19. Nat Cell Biol. 2023. PMID: 36536176
These findings demonstrate that EB1 forms a distinct physical and biochemical membraneless-organelle via multivalent interactions that guide microtubule dynamics....
These findings demonstrate that EB1 forms a distinct physical and biochemical membraneless-organelle via multivalent interactions that gu …
Aldrete Scoring System.
Ding D, Ishag S. Ding D, et al. 2023 Jul 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Jul 8. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 37603628 Free Books & Documents.
Cytomegalovirus Corneal Endotheliitis.
Ding K, Nataneli N. Ding K, et al. 2023 Apr 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2023 Apr 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 35201702 Free Books & Documents.
RNA-based antiviral immunity.
Ding SW. Ding SW. Nat Rev Immunol. 2010 Sep;10(9):632-44. doi: 10.1038/nri2824. Epub 2010 Aug 13. Nat Rev Immunol. 2010. PMID: 20706278 Review.
After amplification by host RNA-dependent RNA polymerases in some cases, these virus-derived siRNAs guide specific antiviral immunity through RNA interference and related RNA silencing effector mechanisms. ...
After amplification by host RNA-dependent RNA polymerases in some cases, these virus-derived siRNAs guide specific antiviral immunity …
Antiviral RNA interference in mammals.
Ding SW, Han Q, Wang J, Li WX. Ding SW, et al. Curr Opin Immunol. 2018 Oct;54:109-114. doi: 10.1016/j.coi.2018.06.010. Epub 2018 Jul 17. Curr Opin Immunol. 2018. PMID: 30015086 Free PMC article. Review.
Infection of plants and insects with RNA and DNA viruses triggers Dicer-dependent production of virus-derived small interfering RNAs (vsiRNAs), which subsequently guide specific virus clearance by RNA interference (RNAi). Consistent with a major antiviral function of RNAi, …
Infection of plants and insects with RNA and DNA viruses triggers Dicer-dependent production of virus-derived small interfering RNAs (vsiRNA …
Deep Learning in RNA Structure Studies.
Yu H, Qi Y, Ding Y. Yu H, et al. Front Mol Biosci. 2022 May 23;9:869601. doi: 10.3389/fmolb.2022.869601. eCollection 2022. Front Mol Biosci. 2022. PMID: 35677883 Free PMC article. Review.
Here, we discuss successful applications of deep learning to solve RNA problems, including predictions of RNA structures, non-canonical G-quadruplex, RNA-protein interactions and RNA switches. Following these cases, we give a general guide to deep learning for solving RNA …
Here, we discuss successful applications of deep learning to solve RNA problems, including predictions of RNA structures, non-canonical G-qu …
Insulin detection in diabetes mellitus: challenges and new prospects.
Vargas E, Nandhakumar P, Ding S, Saha T, Wang J. Vargas E, et al. Nat Rev Endocrinol. 2023 Aug;19(8):487-495. doi: 10.1038/s41574-023-00842-3. Epub 2023 May 22. Nat Rev Endocrinol. 2023. PMID: 37217746 Free PMC article. Review.
Accordingly, an urgent need exists for frequent and real-time insulin measurements to closely track the dynamic blood concentration of insulin during insulin therapy and guide optimal insulin dosing. Nevertheless, traditional centralized insulin testing cannot offer timely …
Accordingly, an urgent need exists for frequent and real-time insulin measurements to closely track the dynamic blood concentration of insul …
[Advances of CRISPR/Cas9 activation system].
Ding X, Pan Z, Yang L, Luo X, Jiang N, Zhu M, Wu C, Lan G, Li P. Ding X, et al. Sheng Wu Gong Cheng Xue Bao. 2022 Aug 25;38(8):2713-2724. doi: 10.13345/j.cjb.220040. Sheng Wu Gong Cheng Xue Bao. 2022. PMID: 36002405 Free article. Review. Chinese.
CRISPR/Cas9 activation system can regulate the expression of multiple genes under the guidance of different guide RNAs to verify gene functions at the regulatory level. This review summarizes the composition of the CRISPR/Cas9 activation system and different activation str …
CRISPR/Cas9 activation system can regulate the expression of multiple genes under the guidance of different guide RNAs to verify gene …
2,651 results