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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1975 3
1977 2
1982 1
1983 2
1984 6
1985 1
1986 3
1987 4
1988 1
1989 11
1990 11
1991 9
1992 11
1993 18
1994 25
1995 32
1996 28
1997 33
1998 45
1999 39
2000 42
2001 68
2002 79
2003 92
2004 125
2005 194
2006 213
2007 264
2008 311
2009 389
2010 499
2011 583
2012 783
2013 951
2014 1170
2015 1362
2016 1584
2017 1831
2018 2268
2019 2727
2020 3505
2021 4438
2022 5571
2023 5971
2024 2659

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34,000 results

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Page 1
CRISPR/Cas9 in Genome Editing and Beyond.
Wang H, La Russa M, Qi LS. Wang H, et al. Annu Rev Biochem. 2016 Jun 2;85:227-64. doi: 10.1146/annurev-biochem-060815-014607. Epub 2016 Apr 25. Annu Rev Biochem. 2016. PMID: 27145843 Review.
The Cas9 protein (CRISPR-associated protein 9), derived from type II CRISPR (clustered regularly interspaced short palindromic repeats) bacterial immune systems, is emerging as a powerful tool for engineering the genome in diverse organisms. As an RNA-guided DNA endonuclea …
The Cas9 protein (CRISPR-associated protein 9), derived from type II CRISPR (clustered regularly interspaced short palindromic repeats) bact …
Parathyroidectomy.
Wang Y, Ladie DE. Wang Y, et al. 2022 Sep 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. 2022 Sep 26. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan–. PMID: 33085421 Free Books & Documents.
With the development of the preoperative localization technique, the minimally invasive surgery using the radio-guided technique, ultrasound imaging, high-resolution endoscopic technique, rapid intraoperative parathyroid hormone (IOPTH) monitoring has been used by many sur …
With the development of the preoperative localization technique, the minimally invasive surgery using the radio-guided technique, ult …
The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a.
Liu L, Li X, Ma J, Li Z, You L, Wang J, Wang M, Zhang X, Wang Y. Liu L, et al. Cell. 2017 Aug 10;170(4):714-726.e10. doi: 10.1016/j.cell.2017.06.050. Epub 2017 Jul 27. Cell. 2017. PMID: 28757251 Free article.
Cas13a, a type VI-A CRISPR-Cas RNA-guided RNA ribonuclease, degrades invasive RNAs targeted by CRISPR RNA (crRNA) and has potential applications in RNA technology. ...The crRNA-target RNA duplex binds in a positively charged central channel of the nuclease (NUC) lobe, and …
Cas13a, a type VI-A CRISPR-Cas RNA-guided RNA ribonuclease, degrades invasive RNAs targeted by CRISPR RNA (crRNA) and has potential a …
Genome manipulation by guide-directed Argonaute cleavage.
Huang S, Wang K, Mayo SL. Huang S, et al. Nucleic Acids Res. 2023 May 8;51(8):4078-4085. doi: 10.1093/nar/gkad188. Nucleic Acids Res. 2023. PMID: 36928676 Free PMC article.
These findings demonstrate the guide-directed cleavage of pAgo on the host genome is mutagenic and can lead to different outcomes according to the function of the host DNA repair machinery. We anticipate this novel DNA-guided interference to be useful in broader gen …
These findings demonstrate the guide-directed cleavage of pAgo on the host genome is mutagenic and can lead to different outcomes acc …
Sgo1 interacts with CENP-A to guide accurate chromosome segregation in mitosis.
Wu F, Akbar H, Wang C, Yuan X, Dou Z, Mullen M, Niu L, Zhang L, Zang J, Wang Z, Yao X, Song X, Liu X. Wu F, et al. J Mol Cell Biol. 2023 Sep 30:mjad061. doi: 10.1093/jmcb/mjad061. Online ahead of print. J Mol Cell Biol. 2023. PMID: 37777834
Taken together, these findings reveal a previously unrecognized but direct link between Sgo1 and CENP-A in centromere plasticity control and illustrate how the Sgo1-CENP-A interaction guides accurate cell division....
Taken together, these findings reveal a previously unrecognized but direct link between Sgo1 and CENP-A in centromere plasticity control and …
Clinical applications and prospects of 3D printing guide templates in orthopaedics.
Meng M, Wang J, Sun T, Zhang W, Zhang J, Shu L, Li Z. Meng M, et al. J Orthop Translat. 2022 May 13;34:22-41. doi: 10.1016/j.jot.2022.03.001. eCollection 2022 May. J Orthop Translat. 2022. PMID: 35615638 Free PMC article. Review.
METHODS: In this paper, a systematic review of the orthopedic guide template is presented, where the history of 3D-printing-guided technology, the process of guides, and basic clinical applications of orthopedic guide templates are described. ...With t …
METHODS: In this paper, a systematic review of the orthopedic guide template is presented, where the history of 3D-printing-guided …
Prime Editing Guide RNA Design Automation Using PINE-CONE.
Standage-Beier K, Tekel SJ, Brafman DA, Wang X. Standage-Beier K, et al. ACS Synth Biol. 2021 Feb 19;10(2):422-427. doi: 10.1021/acssynbio.0c00445. Epub 2021 Jan 19. ACS Synth Biol. 2021. PMID: 33464043 Free PMC article.
Prime editing (PE) is a technology capable of installing genomic edits without double-stranded DNA breaks (DSBs) or donor DNA. Prime editing guide RNAs (pegRNAs) simultaneously encode both guide and edit template sequences. They are more design intensive than CRISPR …
Prime editing (PE) is a technology capable of installing genomic edits without double-stranded DNA breaks (DSBs) or donor DNA. Prime editing …
Bacterial genome engineering using CRISPR RNA-guided transposases.
Gelsinger DR, Vo PLH, Klompe SE, Ronda C, Wang H, Sternberg SH. Gelsinger DR, et al. bioRxiv [Preprint]. 2023 Mar 21:2023.03.18.533263. doi: 10.1101/2023.03.18.533263. bioRxiv. 2023. PMID: 36993567 Free PMC article. Updated. Preprint.
CRISPR-associated transposons (CASTs) have the potential to transform the technology landscape for kilobase-scale genome engineering, by virtue of their ability to integrate large genetic payloads with high accuracy, easy programmability, and no requirement for homologous recombi …
CRISPR-associated transposons (CASTs) have the potential to transform the technology landscape for kilobase-scale genome engineering, by vir …
A systematic review of the accuracy of digital surgical guides for dental implantation.
Shi Y, Wang J, Ma C, Shen J, Dong X, Lin D. Shi Y, et al. Int J Implant Dent. 2023 Oct 25;9(1):38. doi: 10.1186/s40729-023-00507-w. Int J Implant Dent. 2023. PMID: 37875645 Free PMC article. Review.
METHODS: A literature search related to accuracy of surgical guides for dental implantation was performed in Web of Science and PubMed. ...Milling exhibited higher in vivo accuracy of guides than 3d-printing, though further data support was needed. Design of fixatio …
METHODS: A literature search related to accuracy of surgical guides for dental implantation was performed in Web of Science and PubMe …
Deep learning and CRISPR-Cas13d ortholog discovery for optimized RNA targeting.
Wei J, Lotfy P, Faizi K, Baungaard S, Gibson E, Wang E, Slabodkin H, Kinnaman E, Chandrasekaran S, Kitano H, Durrant MG, Duffy CV, Pawluk A, Hsu PD, Konermann S. Wei J, et al. Cell Syst. 2023 Dec 20;14(12):1087-1102.e13. doi: 10.1016/j.cels.2023.11.006. Epub 2023 Dec 12. Cell Syst. 2023. PMID: 38091991
Here, we quantified the performance of over 127,000 RfxCas13d (CasRx) guide RNAs and systematically evaluated seven machine learning models to build a guide efficiency prediction algorithm orthogonally validated across multiple human cell types. ...Our Cas13d gui …
Here, we quantified the performance of over 127,000 RfxCas13d (CasRx) guide RNAs and systematically evaluated seven machine learning …
34,000 results
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