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The Inhibition by Guanfu Base A of Neuropathic Pain Mediated by P2Y(12) Receptor in Dorsal Root Ganglia.
Zou L, Yu K, Fan Y, Cao S, Liu S, Shi L, Li L, Yuan H, Yang R, Yi Z, Gao Y, Li G, Greffrath W, Treede RD, Li M, Xu H, Zhang C, Liang S. Zou L, et al. ACS Chem Neurosci. 2019 Mar 20;10(3):1318-1325. doi: 10.1021/acschemneuro.8b00399. Epub 2018 Dec 10. ACS Chem Neurosci. 2019. PMID: 30475578
The upregulated P2Y(12) receptor expressed in SGCs of the DRG participates in the nociceptive transmission of neuropathic pain. Guanfu base A (GFA) has been reported to exhibit antiarrhythmic and anti-inflammatory effects. ...Sprague-Dawley rats were randomly divided into …
The upregulated P2Y(12) receptor expressed in SGCs of the DRG participates in the nociceptive transmission of neuropathic pain. Guanfu …
Comparative effects of Guanfu base A and Guanfu base G on HERG K+ channel.
Huang X, Yang Y, Zhu J, Xu D, Peng J, Liu J. Huang X, et al. J Cardiovasc Pharmacol. 2012 Jan;59(1):77-83. doi: 10.1097/FJC.0b013e318236e380. J Cardiovasc Pharmacol. 2012. PMID: 21934630
BACKGROUND: Guanfu base A (GFA) and Guanfu base G (GFG) are chemicals isolated from Aconitum coreanum. ...
BACKGROUND: Guanfu base A (GFA) and Guanfu base G (GFG) are chemicals isolated from Aconitum coreanum. ...
Effects of Guanfu total base on Bcl-2 and Bax expression and correlation with atrial fibrillation.
Li Y, Song B, Xu C. Li Y, et al. Hellenic J Cardiol. 2018 Sep-Oct;59(5):274-278. doi: 10.1016/j.hjc.2018.02.009. Epub 2018 Mar 6. Hellenic J Cardiol. 2018. PMID: 29501704 Free article.
OBJECTIVE: This study sought to investigate the effects of Guanfu total base on Bcl-2 and Bax expression and the correlation of Bcl-2 and Bax expression with atrial fibrillation. ...CONCLUSION: Bcl-2 and Bax expression was correlated with atrial fibrillation. Guanfu …
OBJECTIVE: This study sought to investigate the effects of Guanfu total base on Bcl-2 and Bax expression and the correlation of Bcl-2 …
Antiarrhythmic ionic mechanism of Guanfu base A--Selective inhibition of late sodium current in isolated ventricular myocytes from guinea pigs.
Jin SS, Guo Q, Xu J, Yu P, Liu JH, Tang YQ. Jin SS, et al. Chin J Nat Med. 2015 May;13(5):361-7. doi: 10.1016/S1875-5364(15)30027-3. Chin J Nat Med. 2015. PMID: 25986285
The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (INa.L), transient sodium current (INa.T), HERG current (IHERG), and Kv1.5 current (IKv1.5). ...
The present study was designed to determine the effects of Guanfu base A (GFA) on the late sodium current (INa.L), transient sodium c …
Modified FOLFOX6 With or Without Radiation Versus Fluorouracil and Leucovorin With Radiation in Neoadjuvant Treatment of Locally Advanced Rectal Cancer: Initial Results of the Chinese FOWARC Multicenter, Open-Label, Randomized Three-Arm Phase III Trial.
Deng Y, Chi P, Lan P, Wang L, Chen W, Cui L, Chen D, Cao J, Wei H, Peng X, Huang Z, Cai G, Zhao R, Huang Z, Xu L, Zhou H, Wei Y, Zhang H, Zheng J, Huang Y, Zhou Z, Cai Y, Kang L, Huang M, Peng J, Ren D, Wang J. Deng Y, et al. J Clin Oncol. 2016 Sep 20;34(27):3300-7. doi: 10.1200/JCO.2016.66.6198. Epub 2016 Aug 1. J Clin Oncol. 2016. PMID: 27480145 Clinical Trial.