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Page 1
Proximity-Induced Site-Specific Antibody Conjugation.
Yu C, Tang J, Loredo A, Chen Y, Jung SY, Jain A, Gordon A, Xiao H. Yu C, et al. Bioconjug Chem. 2018 Nov 21;29(11):3522-3526. doi: 10.1021/acs.bioconjchem.8b00680. Epub 2018 Nov 1. Bioconjug Chem. 2018. PMID: 30372039
A high conjugation efficiency and specificity was achieved with IgGs from different species and subclasses. The utility of this approach was demonstrated by site-specific conjugation of the small-molecule fluorophore to a native antibody and in vitro characterization of it …
A high conjugation efficiency and specificity was achieved with IgGs from different species and subclasses. The utility of this appro …
Clinical Utility of Antiretinal Antibody Testing.
Chen JJ, McKeon A, Greenwood TM, Flanagan EP, Bhatti MT, Dubey D, Pulido JS, Iezzi R, Smith WM, Sen HN, Gordon LK, Pittock SJ. Chen JJ, et al. JAMA Ophthalmol. 2021 Jun 1;139(6):658-662. doi: 10.1001/jamaophthalmol.2021.0651. JAMA Ophthalmol. 2021. PMID: 33885761 Free PMC article.
An in vivo platform to select and evolve aggregation-resistant proteins.
Ebo JS, Saunders JC, Devine PWA, Gordon AM, Warwick AS, Schiffrin B, Chin SE, England E, Button JD, Lloyd C, Bond NJ, Ashcroft AE, Radford SE, Lowe DC, Brockwell DJ. Ebo JS, et al. Nat Commun. 2020 Apr 14;11(1):1816. doi: 10.1038/s41467-020-15667-1. Nat Commun. 2020. PMID: 32286330 Free PMC article.
Using this assay as a directed evolution screen, we demonstrate the generation of aggregation resistant scFv sequences when reformatted as IgGs. This powerful tool can thus screen and evolve 'manufacturable' biopharmaceuticals early in industrial development. ...
Using this assay as a directed evolution screen, we demonstrate the generation of aggregation resistant scFv sequences when reformatted as …
Lupus anti-ribosomal P autoantibody proteomes express convergent biclonal signatures.
Al Kindi MA, Colella AD, Beroukas D, Chataway TK, Gordon TP. Al Kindi MA, et al. Clin Exp Immunol. 2016 Apr;184(1):29-35. doi: 10.1111/cei.12750. Epub 2016 Jan 29. Clin Exp Immunol. 2016. PMID: 26646815 Free PMC article.
Rib-P- and 11-C peptide-specific IgGs were analysed for heavy (H) and light (L) chain clonality and V-region expression using an electrophoretic and de-novo and database-driven mass spectrometric sequencing workflow. Purified anti-Rib-P and anti-SmD IgGs were tested …
Rib-P- and 11-C peptide-specific IgGs were analysed for heavy (H) and light (L) chain clonality and V-region expression using an elec …
Waning of antibody levels induced by a 13-valent pneumococcal conjugate vaccine, using a 3 + 0 schedule, within the first year of life among children younger than 5 years in Blantyre, Malawi: an observational, population-level, serosurveillance study.
Swarthout TD, Henrion MYR, Thindwa D, Meiring JE, Mbewe M, Kalizang'Oma A, Brown C, Msefula J, Moyo B, Mataya AA, Barnaba S, Pearce E, Gordon M, Goldblatt D, French N, Heyderman RS. Swarthout TD, et al. Lancet Infect Dis. 2022 Dec;22(12):1737-1747. doi: 10.1016/S1473-3099(22)00438-8. Epub 2022 Aug 24. Lancet Infect Dis. 2022. PMID: 36029796 Free PMC article.
Sample selection was based on age category optimisation among children younger than 5 years, adequate sample volume, and available budget. We measured serotype-specific IgGs against the 13 vaccine serotypes (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F) and two n …
Sample selection was based on age category optimisation among children younger than 5 years, adequate sample volume, and available budget. W …
Enabling the formation of native mAb, Fab' and Fc-conjugates using a bis-disulfide bridging reagent to achieve tunable payload-to-antibody ratios (PARs).
Thoreau F, Rochet LNC, Baker JR, Chudasama V. Thoreau F, et al. Chem Sci. 2023 Mar 9;14(14):3752-3762. doi: 10.1039/d2sc06318b. eCollection 2023 Apr 5. Chem Sci. 2023. PMID: 37035695 Free PMC article.
Either as full IgGs or as fragments (Fabs, Fc, etc.), antibodies have received tremendous attention in the development of new therapeutics such as antibody-drug conjugates (ADCs). ...
Either as full IgGs or as fragments (Fabs, Fc, etc.), antibodies have received tremendous attention in the development of new therape …
Serum SmD autoantibody proteomes are clonally restricted and share variable-region peptides.
Al Kindi MA, Chataway TK, Gilada GA, Jackson MW, Goldblatt FM, Walker JG, Colella AD, Gordon TP. Al Kindi MA, et al. J Autoimmun. 2015 Feb;57:77-81. doi: 10.1016/j.jaut.2014.12.005. Epub 2015 Jan 7. J Autoimmun. 2015. PMID: 25577500
Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD protein subunit of the lupus-specific Sm autoantigen. Precipitating SmD-specific IgGs were eluted from native SmD-coated ELISA plates preincubated …
Here, we analysed the clonality and V-region composition of immunoglobulin (Ig) proteomes specific for the immunodominant SmD protein subuni …
An autoantibody in narcolepsy disrupts colonic migrating motor complexes.
Jackson MW, Reed JH, Smith AJ, Gordon TP. Jackson MW, et al. J Neurosci. 2008 Dec 3;28(49):13303-9. doi: 10.1523/JNEUROSCI.4489-08.2008. J Neurosci. 2008. PMID: 19052222 Free PMC article.
The effect of immunoglobulins prepared for clinical intravenous treatment (IVIg) on autoantibody-mediated colonic disruption was also assessed. Narcoleptic IgGs markedly reduced the frequency of CMMCs or irreversibly abolished them. ...
The effect of immunoglobulins prepared for clinical intravenous treatment (IVIg) on autoantibody-mediated colonic disruption was also assess …
Different temporal expression of immunodominant Ro60/60 kDa-SSA and La/SSB apotopes.
Reed JH, Neufing PJ, Jackson MW, Clancy RM, Macardle PJ, Buyon JP, Gordon TP. Reed JH, et al. Clin Exp Immunol. 2007 Apr;148(1):153-60. doi: 10.1111/j.1365-2249.2007.03331.x. Clin Exp Immunol. 2007. PMID: 17286801 Free PMC article.
Multi-parameter flow cytometry was used to define early and late apoptotic populations and their respective binding by monospecific anti-Ro and anti-La IgGs. Anti-Ro60 bound specifically to early apoptotic Jurkat cells and remained accessible on the cell surface throughout …
Multi-parameter flow cytometry was used to define early and late apoptotic populations and their respective binding by monospecific anti-Ro …