Human genomic disease variants: a neutral evolutionary explanation.
Dudley JT, Kim Y, Liu L, Markov GJ, Gerold K, Chen R, Butte AJ, Kumar S.
Dudley JT, et al.
Genome Res. 2012 Aug;22(8):1383-94. doi: 10.1101/gr.133702.111. Epub 2012 Jun 4.
Genome Res. 2012.
PMID: 22665443
Free PMC article.
Review.
For over a decade, the NTME has already explained the origins and distribution of variants implicated in diseases and has illuminated the power of evolutionary thinking in genomic medicine. We suggest that a majority of disease variants in modern populations will have neut …
For over a decade, the NTME has already explained the origins and distribution of variants implicated in diseases and has illuminated the po …