This study was performed to investigate the presence of maternal transfer of resistance to S. mansoni in mice born to Trichinella-infected mothers. T. spiralis-born mice were infected with S. mansoni cercariae. Parasitological study was done at eight and twelve weeks post-schistosomal infection. There was a significant reduction in the number of schistosomes (44.4%), in the liver egg count (38.9%) and in the intestinal egg count (50.46%). Histopathologically, there was a reduction in the number and size of granulomata at the different time intervals, as well as acceleration in the inflammatory reaction.