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TIM-3 as a promising target for cancer immunotherapy in a wide range of tumors.
Sauer N, Janicka N, Szlasa W, Skinderowicz B, Kołodzińska K, Dwernicka W, Oślizło M, Kulbacka J, Novickij V, Karłowicz-Bodalska K. Sauer N, et al. Cancer Immunol Immunother. 2023 Nov;72(11):3405-3425. doi: 10.1007/s00262-023-03516-1. Epub 2023 Aug 11. Cancer Immunol Immunother. 2023. PMID: 37567938 Free PMC article. Review.
Initially identified on the surface of T helper 1 (Th1) lymphocytes and later on cytotoxic lymphocytes (CTLs), monocytes, macrophages, natural killer cells (NKs), and dendritic cells (DCs), TIM-3 plays a key role in immunoregulation. Recently, a growing body of evidence ha …
Initially identified on the surface of T helper 1 (Th1) lymphocytes and later on cytotoxic lymphocytes (CTLs), monocytes, macrophages, natur …
Invasive and non-invasive electrodes for successful drug and gene delivery in electroporation-based treatments.
Malyško-Ptašinskė V, Staigvila G, Novickij V. Malyško-Ptašinskė V, et al. Front Bioeng Biotechnol. 2023 Jan 16;10:1094968. doi: 10.3389/fbioe.2022.1094968. eCollection 2022. Front Bioeng Biotechnol. 2023. PMID: 36727038 Free PMC article. Review.
In the context of cancer treatment, full recovery from an electroporation-based procedure is frequently dependent on the spatial distribution/homogeneity of the electric field in the tissue; therefore, the structure of electrodes/applicators plays an important role. This r …
In the context of cancer treatment, full recovery from an electroporation-based procedure is frequently dependent on the spatial distributio …
Biosynthesis of wyosine derivatives in tRNA(Phe) of Archaea: role of a remarkable bifunctional tRNA(Phe):m1G/imG2 methyltransferase.
Urbonavičius J, Meškys R, Grosjean H. Urbonavičius J, et al. RNA. 2014 Jun;20(6):747-53. doi: 10.1261/rna.043315.113. RNA. 2014. PMID: 24837075 Free PMC article. Review.
This bifunctional tRNA:m(1)G/imG2 methyltransferase, acting on two chemically distinct guanosine derivatives located at the same position of tRNA(Phe), is unique to certain archaea and has no homologs in eukaryotes. This enzyme here referred to as Taw22, probably played an …
This bifunctional tRNA:m(1)G/imG2 methyltransferase, acting on two chemically distinct guanosine derivatives located at the same position of …
Electrochemotherapy for head and neck cancers: possibilities and limitations.
Morozas A, Malyško-Ptašinskė V, Kulbacka J, Ivaška J, Ivaškienė T, Novickij V. Morozas A, et al. Front Oncol. 2024 Feb 15;14:1353800. doi: 10.3389/fonc.2024.1353800. eCollection 2024. Front Oncol. 2024. PMID: 38434679 Free PMC article. Review.
We have also highlighted the significance of assessing the spatial electric field distribution in both tumor and adjacent tissues prior to treatment as it plays a pivotal role in determining treatment success. Finally, we compare the ECT methodology to conventional treatme …
We have also highlighted the significance of assessing the spatial electric field distribution in both tumor and adjacent tissues prior to t …
Polymer brush coated upconverting nanoparticles with improved colloidal stability and cellular labeling.
Klimkevicius V, Voronovic E, Jarockyte G, Skripka A, Vetrone F, Rotomskis R, Katelnikovas A, Karabanovas V. Klimkevicius V, et al. J Mater Chem B. 2022 Jan 26;10(4):625-636. doi: 10.1039/d1tb01644j. J Mater Chem B. 2022. PMID: 34989749
Coating with both polymers increased the upconversion (UC) emission intensity and photoluminescence lifetime values of the UCNPs, which directly translates to more efficient cancer cell labeling nanoprobes. The polymer composition plays a crucial role in the modification o …
Coating with both polymers increased the upconversion (UC) emission intensity and photoluminescence lifetime values of the UCNPs, which dire …
Activated Sintering of Cr2O3-Based Composites by Hot Pressing.
Gevorkyan E, Cepova L, Rucki M, Nerubatskyi V, Morozow D, Zurowski W, Barsamyan V, Kouril K. Gevorkyan E, et al. Materials (Basel). 2022 Aug 29;15(17):5960. doi: 10.3390/ma15175960. Materials (Basel). 2022. PMID: 36079341 Free PMC article.
The proposed novel method allowed for interaction between aluminum and chromia, thus avoiding the decomposition of the latter. Here, ultrafine aluminum powder played the role of the active agent forming a liquid phase and reacting with Cr(2)O(3). ...
The proposed novel method allowed for interaction between aluminum and chromia, thus avoiding the decomposition of the latter. Here, ultrafi …
Material's Strength Analysis of the Coupling Node of Axle of the Truck Trailer.
Decker Ž, Tretjakovas J, Drozd K, Rudzinskas V, Walczak M, Kilikevičius A, Matijosius J, Boretska I. Decker Ž, et al. Materials (Basel). 2023 Apr 26;16(9):3399. doi: 10.3390/ma16093399. Materials (Basel). 2023. PMID: 37176280 Free PMC article.
Road transport plays an important role in the transport of goods and people and is important for the national economy. ...
Road transport plays an important role in the transport of goods and people and is important for the national economy. ...
Long-Term Shape, Curvature, and Depth Changes of the Lamina Cribrosa after Trabeculectomy.
Kadziauskienė A, Jašinskienė E, Ašoklis R, Lesinskas E, Rekašius T, Chua J, Cheng CY, Mari JM, Girard MJA, Schmetterer L. Kadziauskienė A, et al. Ophthalmology. 2018 Nov;125(11):1729-1740. doi: 10.1016/j.ophtha.2018.05.011. Epub 2018 Jun 28. Ophthalmology. 2018. PMID: 29961552
Change in LC global shape appeared to be temporal. Reduction in IOP plays an important role in the early phase of LC change; however, in the later phase, LC remodeling may play a crucial role in view of stable IOP....
Change in LC global shape appeared to be temporal. Reduction in IOP plays an important role in the early phase of LC change; however, …
β-Glucan from Saccharomyces cerevisiae Induces IFN-γ Production In Vivo in BALB/c Mice.
Javmen A, Nemeikaitė-Čėnienė A, Bratchikov M, Grigiškis S, Grigas F, Jonauskienė I, Zabulytė D, Mauricas M. Javmen A, et al. In Vivo. 2015 May-Jun;29(3):359-63. In Vivo. 2015. PMID: 25977381
Moreover, water-soluble beta-glucan enhanced IFN-gamma production more effectively than did particulate beta-glucan. CONCLUSION: IFN-gamma plays an important role in immunity against viral and bacterial infections. ...
Moreover, water-soluble beta-glucan enhanced IFN-gamma production more effectively than did particulate beta-glucan. CONCLUSION: IFN-gamma …