Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2017 1
2018 1
2022 1
2023 5
2024 5

Text availability

Article attribute

Article type

Publication date

Search Results

10 results

Results by year

Filters applied: . Clear all
Page 1
Structural basis of Gabija anti-phage defence and viral immune evasion.
Antine SP, Johnson AG, Mooney SE, Leavitt A, Mayer ML, Yirmiya E, Amitai G, Sorek R, Kranzusch PJ. Antine SP, et al. Nature. 2024 Jan;625(7994):360-365. doi: 10.1038/s41586-023-06855-2. Epub 2023 Nov 22. Nature. 2024. PMID: 37992757 Free PMC article.
Gabija protein A (GajA) is a DNA endonuclease that tetramerizes to form the core of the anti-phage defence complex. ...We show that a phage-encoded protein, Gabija anti-defence 1 (Gad1), directly binds to the Gabija GajAB complex and inactivates defence. ...
Gabija protein A (GajA) is a DNA endonuclease that tetramerizes to form the core of the anti-phage defence complex. ...We show that a …
Structures and activation mechanism of the Gabija anti-phage system.
Li J, Cheng R, Wang Z, Yuan W, Xiao J, Zhao X, Du X, Xia S, Wang L, Zhu B, Wang L. Li J, et al. Nature. 2024 Mar 12. doi: 10.1038/s41586-024-07270-x. Online ahead of print. Nature. 2024. PMID: 38471529
GajA functions as a DNA endonuclease that is inactive in the presence of ATP(9). Here, to explore how the Gabija system is activated for anti-phage defence, we report its cryo-electron microscopy structures in five states, including apo GajA, GajA in complex with DN …
GajA functions as a DNA endonuclease that is inactive in the presence of ATP(9). Here, to explore how the Gabija system is activated …
Bacterial defense systems exhibit synergistic anti-phage activity.
Wu Y, Garushyants SK, van den Hurk A, Aparicio-Maldonado C, Kushwaha SK, King CM, Ou Y, Todeschini TC, Clokie MRJ, Millard AD, Gençay YE, Koonin EV, Nobrega FL. Wu Y, et al. Cell Host Microbe. 2024 Apr 10;32(4):557-572.e6. doi: 10.1016/j.chom.2024.01.015. Epub 2024 Feb 22. Cell Host Microbe. 2024. PMID: 38402614 Free article.
Notably, Zorya II synergizes with Druantia III and ietAS defense systems, while tmn exhibits synergy with co-occurring systems Gabija, Septu I, and PrrC. For Gabija, tmn co-opts the sensory switch ATPase domain, enhancing anti-phage activity. ...
Notably, Zorya II synergizes with Druantia III and ietAS defense systems, while tmn exhibits synergy with co-occurring systems Gabija …
Molecular basis of Gabija anti-phage supramolecular assemblies.
Yang XY, Shen Z, Xie J, Greenwald J, Marathe I, Lin Q, Xie WJ, Wysocki VH, Fu TM. Yang XY, et al. Nat Struct Mol Biol. 2024 Apr 16. doi: 10.1038/s41594-024-01283-w. Online ahead of print. Nat Struct Mol Biol. 2024. PMID: 38627580
As one of the most prevalent anti-phage defense systems in prokaryotes, Gabija consists of a Gabija protein A (GajA) and a Gabija protein B (GajB). The assembly and function of the Gabija system remain unclear. Here we present cryo-EM structures of Bac …
As one of the most prevalent anti-phage defense systems in prokaryotes, Gabija consists of a Gabija protein A (GajA) and a …
OLD family nuclease function across diverse anti-phage defense systems.
Akritidou K, Thurtle-Schmidt BH. Akritidou K, et al. Front Microbiol. 2023 Sep 28;14:1268820. doi: 10.3389/fmicb.2023.1268820. eCollection 2023. Front Microbiol. 2023. PMID: 37840731 Free PMC article. Review.
Despite being discovered over 50 years ago, OLD nuclease function remained mysterious until recent biochemical, structural, and bioinformatic studies revealed that OLD nucleases protect bacteria by functioning in diverse anti-phage defense systems including the Gabija syst …
Despite being discovered over 50 years ago, OLD nuclease function remained mysterious until recent biochemical, structural, and bioinformati …
Landscape of New Nuclease-Containing Antiphage Systems in Escherichia coli and the Counterdefense Roles of Bacteriophage T4 Genome Modifications.
Wang S, Sun E, Liu Y, Yin B, Zhang X, Li M, Huang Q, Tan C, Qian P, Rao VB, Tao P. Wang S, et al. J Virol. 2023 Jun 29;97(6):e0059923. doi: 10.1128/jvi.00599-23. Epub 2023 Jun 12. J Virol. 2023. PMID: 37306585 Free PMC article.
Our analysis identified at least 17 nuclease-containing defense systems in E. coli, with type III Druantia being the most abundant system, followed by Zorya, Septu, Gabija, AVAST type 4, and qatABCD. Of these, 8 nuclease-containing systems were found to be active against p …
Our analysis identified at least 17 nuclease-containing defense systems in E. coli, with type III Druantia being the most abundant system, f …
dbAPIS: a database of anti-prokaryotic immune system genes.
Yan Y, Zheng J, Zhang X, Yin Y. Yan Y, et al. Nucleic Acids Res. 2024 Jan 5;52(D1):D419-D425. doi: 10.1093/nar/gkad932. Nucleic Acids Res. 2024. PMID: 37889074 Free PMC article.
The key features of dbAPIS include: (i) experimentally verified APIS genes with their protein sequences, functional annotation, PDB or AlphaFold predicted structures, genomic context, sequence and structural homologs from different microbiome/virome databases; (ii) classification …
The key features of dbAPIS include: (i) experimentally verified APIS genes with their protein sequences, functional annotation, PDB or Alpha …
Consequences of an extreme diet in the professional sport: Refeeding syndrome to a bodybuilder.
Lapinskienė I, Mikulevičienė G, Laubner G, Badaras R. Lapinskienė I, et al. Clin Nutr ESPEN. 2018 Feb;23:253-255. doi: 10.1016/j.clnesp.2017.10.003. Epub 2017 Nov 2. Clin Nutr ESPEN. 2018. PMID: 29460810
Severe hypokalemia, hypophosphatemia, hypomagnesemia and hyperglycemia with mildly elevated liver enzymes have occurred. The patient could barely move his legs and arms, and his state has been followed by a hypertensive crisis, which required an immediate intravenous treat …
Severe hypokalemia, hypophosphatemia, hypomagnesemia and hyperglycemia with mildly elevated liver enzymes have occurred. The patient could b …