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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1989 1
1991 7
1992 2
1993 3
1994 2
1995 6
1996 1
1997 3
1998 4
1999 1
2000 13
2001 4
2002 7
2003 9
2004 11
2005 20
2006 26
2007 19
2008 20
2009 30
2010 14
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2012 26
2013 27
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845 results

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Page 1
Engineered CRISPR-OsCas12f1 and RhCas12f1 with robust activities and expanded target range for genome editing.
Kong X, Zhang H, Li G, Wang Z, Kong X, Wang L, Xue M, Zhang W, Wang Y, Lin J, Zhou J, Shen X, Wei Y, Zhong N, Bai W, Yuan Y, Shi L, Zhou Y, Yang H. Kong X, et al. Nat Commun. 2023 Apr 11;14(1):2046. doi: 10.1038/s41467-023-37829-7. Nat Commun. 2023. PMID: 37041195 Free PMC article.
Through protein and sgRNA engineering, we generate enhanced OsCas12f1 (enOsCas12f1) and enRhCas12f1 variants, with 5'-TTN and 5'-CCD (D = not C) PAMs respectively, exhibiting much higher editing efficiency and broader PAMs, compared with the engineered variant Un1Cas12f1 (Un1Cas1 …
Through protein and sgRNA engineering, we generate enhanced OsCas12f1 (enOsCas12f1) and enRhCas12f1 variants, with 5'-TTN and 5'-CCD (D = no …
Development of miniature base editors using engineered IscB nickase.
Han D, Xiao Q, Wang Y, Zhang H, Dong X, Li G, Kong X, Wang S, Song J, Zhang W, Zhou J, Bi L, Yuan Y, Shi L, Zhong N, Yang H, Zhou Y. Han D, et al. Nat Methods. 2023 Jul;20(7):1029-1036. doi: 10.1038/s41592-023-01898-9. Epub 2023 May 25. Nat Methods. 2023. PMID: 37231266
Here we describe the engineering of OgeuIscB and its corresponding omegaRNA to develop an IscB system that is highly efficient in mammalian systems, named enIscB. By fusing enIscB with T5 exonuclease (T5E), we found enIscB-T5E exhibited comparable targeting efficiency to S …
Here we describe the engineering of OgeuIscB and its corresponding omegaRNA to develop an IscB system that is highly efficient in mammalian …
Decreasing predictable DNA off-target effects and narrowing editing windows of adenine base editors by fusing human Rad18 protein variant.
Wang Z, Yuan H, Yang L, Ma L, Zhang Y, Deng J, Li X, Xiao W, Li Z, Qiu J, Ouyang H, Pang D. Wang Z, et al. Int J Biol Macromol. 2023 Dec 31;253(Pt 7):127418. doi: 10.1016/j.ijbiomac.2023.127418. Epub 2023 Oct 16. Int J Biol Macromol. 2023. PMID: 37848112 Free article.
Here, we report human e18 protein, a RING type E3 ubiquitin ligase variant, fusing with adenine base editors can significantly improve the preciseness and narrow the editing windows compared with ABEmax and ABE8e by diminishing the abundance of base editor protein. ...Furt …
Here, we report human e18 protein, a RING type E3 ubiquitin ligase variant, fusing with adenine base editors can significantly improv …
Enantioselective Total Synthesis of (+)-Pepluanol A.
Yuan P, Gaich T. Yuan P, et al. Org Lett. 2022 Jul 8;24(26):4717-4721. doi: 10.1021/acs.orglett.2c00961. Epub 2022 May 11. Org Lett. 2022. PMID: 35543422
Herein, we report an enantioselective and convergent total synthesis of (+)-pepluanol A, a structurally intriguing Euphorbia diterpenoid natural product featuring a 5/6/7/3-fused tetracyclic skeleton, from known building blocks in 11 steps. ...
Herein, we report an enantioselective and convergent total synthesis of (+)-pepluanol A, a structurally intriguing Euphorbia diterpenoid nat …
Hopping Pits Catch Fusing Granules.
Haucke V. Haucke V. Dev Cell. 2015 Oct 12;35(1):10-1. doi: 10.1016/j.devcel.2015.09.026. Dev Cell. 2015. PMID: 26460943 Free article.
In excitable cells, regulated exocytosis is coupled to endocytic membrane retrieval. Yuan et al. (2015) in this issue of Developmental Cell report a possible mechanism for such exo-endocytic coupling that is based on stimulation-induced hopping of clathrin-containing endoc …
In excitable cells, regulated exocytosis is coupled to endocytic membrane retrieval. Yuan et al. (2015) in this issue of Developmenta …
Bioinspired Total Synthesis of (+)-Euphorikanin A.
Chen Z, Zhao K, Jia Y. Chen Z, et al. Angew Chem Int Ed Engl. 2022 Apr 11;61(16):e202200576. doi: 10.1002/anie.202200576. Epub 2022 Feb 21. Angew Chem Int Ed Engl. 2022. PMID: 35165997
We have achieved a bioinspired total synthesis of (+)-euphorikanin A, which possesses an intriguing and complex 5/6/7/3-fused tetracyclic skeleton bearing a bridged [3.2.1]-gamma-lactone moiety. ...
We have achieved a bioinspired total synthesis of (+)-euphorikanin A, which possesses an intriguing and complex 5/6/7/3-fused tetracy …
Programmable deaminase-free base editors for G-to-Y conversion by engineered glycosylase.
Tong H, Liu N, Wei Y, Zhou Y, Li Y, Wu D, Jin M, Cui S, Li H, Li G, Zhou J, Yuan Y, Zhang H, Shi L, Yao X, Yang H. Tong H, et al. Natl Sci Rev. 2023 May 16;10(8):nwad143. doi: 10.1093/nsr/nwad143. eCollection 2023 Aug. Natl Sci Rev. 2023. PMID: 37404457 Free PMC article.
Here we developed a deaminase-free glycosylase-based guanine base editor (gGBE) with G editing ability, by fusing Cas9 nickase with engineered N-methylpurine DNA glycosylase protein (MPG). ...
Here we developed a deaminase-free glycosylase-based guanine base editor (gGBE) with G editing ability, by fusing Cas9 nickase with e …
Lorlatinib for ALK-fused, infant-type hemispheric glioma with lung metastasis: a case report.
Lai M, Li S, Li H, Hu Q, Li J, Zhou J, Ai R, Zhen J, Zhou Z, Wang L, Zhang Y, Hu W, Yuan L, Ma X, Zhang X, Song C, Li Z, Cai L. Lai M, et al. Ann Clin Transl Neurol. 2023 May;10(5):836-841. doi: 10.1002/acn3.51766. Epub 2023 Mar 31. Ann Clin Transl Neurol. 2023. PMID: 37000961 Free PMC article.
This typical case demonstrated the importance of appropriate molecularly targeted treatments in ALK-fused tumors, and lorlatinib may serve as an effective complement to conventional chemotherapy and radiotherapy in primary glioma harboring ALK fusions and its metastasis... …
This typical case demonstrated the importance of appropriate molecularly targeted treatments in ALK-fused tumors, and lorlatinib may …
SDV-LOAM: Semi-Direct Visual-LiDAR Odometry and Mapping.
Yuan Z, Wang Q, Cheng K, Hao T, Yang X. Yuan Z, et al. IEEE Trans Pattern Anal Mach Intell. 2023 Sep;45(9):11203-11220. doi: 10.1109/TPAMI.2023.3262817. Epub 2023 Aug 7. IEEE Trans Pattern Anal Mach Intell. 2023. PMID: 37030871
Visual-LiDAR odometry and mapping (V-LOAM), which fuses complementary information of a camera and a LiDAR, is an attractive solution for accurate and robust pose estimation and mapping. ...
Visual-LiDAR odometry and mapping (V-LOAM), which fuses complementary information of a camera and a LiDAR, is an attractive solution …
845 results