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Metabolic reprogramming of fibro/adipogenic progenitors facilitates muscle regeneration.
Reggio A, Rosina M, Krahmer N, Palma A, Petrilli LL, Maiolatesi G, Massacci G, Salvatori I, Valle C, Testa S, Gargioli C, Fuoco C, Castagnoli L, Cesareni G, Sacco F. Reggio A, et al. Life Sci Alliance. 2020 Feb 4;3(3):e202000646. doi: 10.26508/lsa.202000660. Print 2020 Mar. Life Sci Alliance. 2020. PMID: 32019766 Free PMC article.
By combining our proteomic dataset with a literature-derived signaling network, we revealed that HFD modulates the beta-catenin-follistatin axis. These changes are accompanied by significant amelioration of the histological phenotype in dystrophic mice. ...
By combining our proteomic dataset with a literature-derived signaling network, we revealed that HFD modulates the beta-catenin-folli …
Dominant frontonasal dysplasia with ectodermal defects results from increased activity of ALX4.
Peled A, Sarig O, Mohamad J, Eskin-Schwartz M, Vodo D, Bochner R, Malchin N, Isakov O, Shomron N, Fainberg G, Bertolini M, Paus R, Sprecher E. Peled A, et al. Am J Med Genet A. 2023 Dec;191(12):2806-2812. doi: 10.1002/ajmg.a.63408. Epub 2023 Sep 19. Am J Med Genet A. 2023. PMID: 37724761
Using a reporter assay, we showed that the elongated ALX4 displays increased activity. ALX4 negatively regulates the Wnt/beta-catenin pathway and accordingly, patient keratinocytes showed altered expression of genes associated with the WNT/beta-catenin pathway, whic …
Using a reporter assay, we showed that the elongated ALX4 displays increased activity. ALX4 negatively regulates the Wnt/beta-catenin …
Keratin nanoparticles and photodynamic therapy enhance the anticancer stem cells activity of salinomycin.
Avancini G, Guerrini A, Ferroni C, Tedesco D, Ballestri M, Columbaro M, Menilli L, Reddi E, Costa R, Leanza L, Varchi G, Moret F. Avancini G, et al. Mater Sci Eng C Mater Biol Appl. 2021 Mar;122:111899. doi: 10.1016/j.msec.2021.111899. Epub 2021 Jan 23. Mater Sci Eng C Mater Biol Appl. 2021. PMID: 33641902
In vivo experiments on zebrafish embryos confirmed the capacity of SAL nanoformulations to interfere with the Wnt/beta-catenin signaling pathway, which is dysregulated in BC, thus identifying a target for further translation into pre-clinical models....
In vivo experiments on zebrafish embryos confirmed the capacity of SAL nanoformulations to interfere with the Wnt/beta-catenin signal …
Sfrp4 repression of the Ror2/Jnk cascade in osteoclasts protects cortical bone from excessive endosteal resorption.
Chen K, Ng PY, Chen R, Hu D, Berry S, Baron R, Gori F. Chen K, et al. Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14138-14143. doi: 10.1073/pnas.1900881116. Epub 2019 Jun 25. Proc Natl Acad Sci U S A. 2019. PMID: 31239337 Free PMC article.
Sfrp4 deletion in OCs resulted in activation of canonical Wnt/beta-catenin and noncanonical Wnt/Ror2/Jnk signaling cascades. However, while inhibition of canonical Wnt/beta-catenin signaling did not alter the effect of Sfrp4 on OCgenesis, blocking the noncanonical W …
Sfrp4 deletion in OCs resulted in activation of canonical Wnt/beta-catenin and noncanonical Wnt/Ror2/Jnk signaling cascades. However, …
Melanoma and immunotherapy bridge 2015 : Naples, Italy. 1-5 December 2015.
Nanda VGY, Peng W, Hwu P, Davies MA, Ciliberto G, Fattore L, Malpicci D, Aurisicchio L, Ascierto PA, Croce CM, Mancini R, Spranger S, Gajewski TF, Wang Y, Ferrone S, Vanpouille-Box C, Wennerberg E, Pilones KA, Formenti SC, Demaria S, Tang H, Wang Y, Fu YX, Dummer R, Puzanov I, Tarhini A, Chauvin JM, Pagliano O, Fourcade J, Sun Z, Wang H, Sanders C, Kirkwood JM, Chen THT, Maurer M, Korman AJ, Zarour HM, Stroncek DF, Huber V, Rivoltini L, Thurin M, Rau T, Lugli A, Pagès F, Camarero J, Sancho A, Jommi C, de Coaña YP, Wolodarski M, Yoshimoto Y, Gentilcore G, Poschke I, Masucci GV, Hansson J, Kiessling R, Scognamiglio G, Sabbatino F, Marino FZ, Anniciello AM, Cantile M, Cerrone M, Scala S, D’alterio C, Ianaro A, Cirin G, Liguori G, Bott G, Chapman PB, Robert C, Larkin J, Haanen JB, Ribas A, Hogg D, Hamid O, Testori A, Lorigan P, Sosman JA, Flaherty KT, Yue H, Coleman S, Caro I, Hauschild A, McArthur GA, Sznol M, Callahan MK, Kluger H, Postow MA, Gordan R, Segal NH, Rizvi NA, Lesokhin A, Atkins MB, Burke MM, Ralabate A, Rivera A, Kronenberg SA, Agunwamba B, Ruisi M, Horak C, Jiang J, Wolchok J, Ascierto PA, Liszkay G, Maio M, Mandalà M, Demidov L, Stoyakovskiy D, Thomas L, de la Cruz-Me… See abstract for full author list ➔ Nanda VGY, et al. J Transl Med. 2016 Jul 25;14(1):65. doi: 10.1186/s12967-016-0791-2. J Transl Med. 2016. PMID: 27461275 Free PMC article.
Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gennaro Ciliberto, Luigi Fattore, Debora Malpicci, Luigi Aurisicchio, Paolo Antonio Ascierto, Carlo M. Croce, Rita Mancini K3 Tumor-intrinsic b …
Davies K2 Non-mutational adaptive changes in melanoma cells exposed to BRAF and MEK inhibitors help the establishment of drug resistance Gen …
Genetic Determinants in a Critical Domain of NS5A Correlate with Hepatocellular Carcinoma in Cirrhotic Patients Infected with HCV Genotype 1b.
Alkhatib M, Di Maio VC, De Murtas V, Polilli E, Milana M, Teti E, Fiorentino G, Calvaruso V, Barbaliscia S, Bertoli A, Scutari R, Carioti L, Cento V, Santoro MM, Orro A, Maida I, Lenci I, Sarmati L, Craxì A, Pasquazzi C, Parruti G, Babudieri S, Milanesi L, Andreoni M, Angelico M, Perno CF, Ceccherini-Silberstein F, Svicher V, Salpini R, On Behalf Of Hirma Hepatocarcinoma Innovative Research MArkers And Fondazione Vironet C Hcv Virology Italian Resistance. Alkhatib M, et al. Viruses. 2021 Apr 23;13(5):743. doi: 10.3390/v13050743. Viruses. 2021. PMID: 33922732 Free PMC article.
Notably, these mutations reside in NS5A regions known to interact with cellular proteins crucial for cell-cycle regulation (p53, p85-PIK3, and beta-catenin), and introduce additional phosphorylation sites, a phenomenon known to ameliorate NS5A interaction with cellular pro …
Notably, these mutations reside in NS5A regions known to interact with cellular proteins crucial for cell-cycle regulation (p53, p85-PIK3, a …
In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice.
Maranghi F, Lorenzetti S, Tassinari R, Moracci G, Tassinari V, Marcoccia D, Di Virgilio A, Eusepi A, Romeo A, Magrelli A, Salvatore M, Tosto F, Viganotti M, Antoccia A, Di Masi A, Azzalin G, Tanzarella C, Macino G, Taruscio D, Mantovani A. Maranghi F, et al. Reprod Toxicol. 2010 Jul;29(4):427-32. doi: 10.1016/j.reprotox.2010.03.002. Epub 2010 Mar 20. Reprod Toxicol. 2010. PMID: 20307648
In utero DEHP exposure altered post-natal liver development in weanling mice causing significant, dose-related (i) increased hepatosteatosis, (ii) decreased glycogen storage, (iii) increased beta-catenin intracytoplasmic localization (females only). At puberty, significant …
In utero DEHP exposure altered post-natal liver development in weanling mice causing significant, dose-related (i) increased hepatosteatosis …
Synergistic effect of interleukin-10-receptor variants in a case of early-onset ulcerative colitis.
Galatola M, Miele E, Strisciuglio C, Paparo L, Rega D, Delrio P, Duraturo F, Martinelli M, Rossi GB, Staiano A, Izzo P, De Rosa M. Galatola M, et al. World J Gastroenterol. 2013 Dec 14;19(46):8659-70. doi: 10.3748/wjg.v19.i46.8659. World J Gastroenterol. 2013. PMID: 24379584 Free PMC article.
METHODS: We analysed the interleukin-10 (IL10) receptor genes at the DNA and RNA level in the proband and his relatives. Beta catenin and tumor necrosis factor-alpha (TNFalpha) receptors were analysed in the proteins extracted from peripheral blood cells of the proband, hi …
METHODS: We analysed the interleukin-10 (IL10) receptor genes at the DNA and RNA level in the proband and his relatives. Beta catenin …
IL-1β and TGF-β weaken the placental barrier through destruction of tight junctions: an in vivo and in vitro study.
Tossetta G, Paolinelli F, Avellini C, Salvolini E, Ciarmela P, Lorenzi T, Emanuelli M, Toti P, Giuliante R, Gesuita R, Crescimanno C, Voltolini C, Di Primio R, Petraglia F, Castellucci M, Marzioni D. Tossetta G, et al. Placenta. 2014 Jul;35(7):509-16. doi: 10.1016/j.placenta.2014.03.016. Epub 2014 Apr 15. Placenta. 2014. PMID: 24768095
METHODS: In the present study, first we aimed to evaluate the protein expression (by immunohistochemistry and western blotting) and mRNA (by real time PCR) levels of the molecular components of tight junctions (Zonula occludens-1 and occludin), and of adherent junctions (VE-cadhe …
METHODS: In the present study, first we aimed to evaluate the protein expression (by immunohistochemistry and western blotting) and mRNA (by …