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Metformin administration induces hepatotoxic effects in paraoxonase-1-deficient mice.
Chem Biol Interact. 2016 Apr 5;249:56-63. doi: 10.1016/j.cbi.2016.03.004. Epub 2016 Mar 3.
Chem Biol Interact. 2016.
PMID: 26945512
Metformin administration aggravated inflammation in animals given a standard mouse chow and in those fed a high-fat diet. Also, it was associated with a higher degree of steatosis in animals fed a standard chow diet. ...
Metformin administration aggravated inflammation in animals given a standard mouse chow and in those fed a high-fat diet. Also, it wa …
Chemokine (C-C motif) ligand 2 gene ablation protects low-density lipoprotein and paraoxonase-1 double deficient mice from liver injury, oxidative stress and inflammation.
Luciano-Mateo F, Cabré N, Fernández-Arroyo S, Baiges-Gaya G, Hernández-Aguilera A, Rodríguez-Tomàs E, Mercado-Gómez M, Menendez JA, Camps J, Joven J.
Luciano-Mateo F, et al.
Biochim Biophys Acta Mol Basis Dis. 2019 Jun 1;1865(6):1555-1566. doi: 10.1016/j.bbadis.2019.03.006. Epub 2019 Mar 21.
Biochim Biophys Acta Mol Basis Dis. 2019.
PMID: 30905786
Free article.
Mass spectrometry methods were used to assess the liver metabolic response in mice fed either regular chow or a high-fat diet. Dietary fat caused liver steatosis, oxidative stress and the accumulation of pro-inflammatory macrophages in the livers of double deficient mice. …
Mass spectrometry methods were used to assess the liver metabolic response in mice fed either regular chow or a high-fat diet. Dietar …
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