Effects of lysine 2-hydroxyisobutyrylation on bacterial FabI activity and resistance to triclosan.
Zheng Y, Dong H, Bai X, Cui H, Li MJ, Wu HY, Zhang K.
Zheng Y, et al.
Biochimie. 2021 Mar;182:197-205. doi: 10.1016/j.biochi.2021.01.011. Epub 2021 Jan 21.
Biochimie. 2021.
PMID: 33485933
However, the dissociation constant (K(D)) between FabI and NADH was not affected by the mutation mimicking the modification, suggesting that K201(hib) didn't alter the binding between NADH and FabI. We also found that K201(hib) tended to increase the resistance of E …
However, the dissociation constant (K(D)) between FabI and NADH was not affected by the mutation mimicking the modification, suggesti …