SHANK2 mutations associated with autism spectrum disorder cause hyperconnectivity of human neurons.
Zaslavsky K, Zhang WB, McCready FP, Rodrigues DC, Deneault E, Loo C, Zhao M, Ross PJ, El Hajjar J, Romm A, Thompson T, Piekna A, Wei W, Wang Z, Khattak S, Mufteev M, Pasceri P, Scherer SW, Salter MW, Ellis J.
Zaslavsky K, et al.
Nat Neurosci. 2019 Apr;22(4):556-564. doi: 10.1038/s41593-019-0365-8. Epub 2019 Mar 25.
Nat Neurosci. 2019.
PMID: 30911184
Free PMC article.
We observed increases in dendrite length, dendrite complexity, synapse number, and frequency of spontaneous excitatory postsynaptic currents. These findings were phenocopied in gene-edited homozygous SHANK2 knockout cells and rescued by gene correction of an ASD SHA …
We observed increases in dendrite length, dendrite complexity, synapse number, and frequency of spontaneous excitatory postsynapti …